Quinapril hydrochloride + Hydrochlorothiazide
Consumer Medicine Information
NOTICE: This Consumer Medicine Information (CMI) is intended for persons
living in Australia. This page contains answers to some common
. It does
not contain all the information that is known about
. It does not take the
place of talking to your doctor or pharmacist. All medicines have risks
and benefits. Your doctor has weighed the risk of you using this medicine
against the benefits he/she expects it will have for you. If you have
any concerns about using this medicine, ask your doctor or pharmacist.
Bookmark or print this page, you may need to read it again.
What ACCURETIC is used for
ACCURETIC is a combination of a medicine called angiotensin converting enzyme (ACE) inhibitor and a water tablet (diuretic).
ACCURETIC is used to lower high blood pressure (hypertension). Everyone has blood pressure. This pressure helps get your
blood all around your body. Your blood pressure may be different at different times of the day, depending on how busy or
worried you are. You have hypertension (high blood pressure) when your blood pressure stays higher than is needed, even when
you are calm and relaxed.
There are usually no symptoms of hypertension. The only way of knowing that you have hypertension is to have your blood pressure
checked on a regular basis. If high blood pressure is not treated it can lead to serious health problems, including stroke,
heart disease and kidney failure.
How ACCURETIC works
ACCURETIC works by widening your blood vessels, which reduces pressure in the vessels, making it easier for your heart to
pump blood around your body.
ACCURETIC also works by making your kidneys pass more water and salt and retain more potassium. This helps reduce high blood
Your doctor may have prescribed ACCURETIC for another reason. Ask your doctor if you have any questions about why ACCURETIC
has been prescribed for you.
ACCURETIC is not addictive.
This medicine is available only with a doctor's prescription.
Before you take ACCURETIC
When you must not take it
Do not take ACCURETIC if:
you have an allergy to ACCURETIC or any other medicine containing quinapril, hydrochlorothiazide, or any of the ingredients
listed at the end of this leaflet
you have an allergy to any sulfonamide or sulfur medicines.
One of the active ingredients of ACCURETIC, hydrochlorothiazide, is a sulfur-containing medicine (a sulfonamide). Therefore,
if you are allergic to sulfur medicines, such as some antibiotics, you are likely to be allergic to ACCURETIC. Check with
your doctor or pharmacist if you are not sure whether you are allergic to sulfur medicines.
Symptoms of an allergic reaction to ACCURETIC may include skin rash, itchiness, shortness of breath, swelling of the face,
lips or tongue, muscle pain or tenderness or joint pain.
you have taken any other 'ACE inhibitor' medicine before, which caused your face, lips, tongue, throat, hands or feet to swell
up, or made it hard for you to breathe.
If you have had an allergic reaction to an ACE inhibitor before, you may be allergic to ACCURETIC.
you or your family have a history of swelling of the face, lips, tongue, throat, hands or feet for no apparent reason.
you have kidney problems or a condition called 'renal artery stenosis'.
you have regular dialysis for blood filtration.
You may experience an allergic reaction.
Do not take ACCURETIC if you are diabetic or have kidney problems and are currently taking a medicine called aliskiren. This
medicine is used to treat high blood pressure.
You may experience severe side effects.
Do not take ACCURETIC if you are pregnant or breastfeeding.
ACCURETIC may enter your womb or it may pass into the breast milk and there is the possibility that your baby may be affected.
Do not take ACCURETIC after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.
If you are not sure whether you should start taking ACCURETIC, talk to your doctor.
Before you start to take it
Tell your doctor if you have allergies to:
any other medicines
any other substances, such as foods, preservatives or dyes.
Tell your doctor if you have or have had any medical conditions, especially the following:
kidney problems, or are having dialysis
low blood pressure, which you may notice as dizziness or light-headedness
high levels of potassium in your blood
Systemic Lupus Erythematosus (SLE), scleroderma or other autoimmune diseases.
You must also tell your doctor if you:
are following a very low salt diet
are about to receive desensitisation therapy for an allergy
are about to undergo dialysis or lipoprotein apheresis
are about to have surgery or a general anaesthetic
plan to become pregnant or breastfeed.
If you have not told your doctor about any of the above, tell him/her before you start taking ACCURETIC.
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any that you buy without a prescription from
your pharmacy, supermarket or health food shop.
Some medicines and ACCURETIC may interfere with each other. These include:
other medicines used to treat high blood pressure
other medicines that work in a similar fashion to ACE inhibitors, such as Angiotensin Receptor Blockers (these are used to
treat high blood pressure and/or heart failure).
other diuretics, also known as fluid or water tablets
non-steroidal anti-inflammatory drugs (NSAIDs) or Cox 2 inhibiting medicines used to relieve pain, swelling and other symptoms
of inflammation, including arthritis
potassium supplements or potassium-containing salt substitutes
lithium, a medicine used to treat mood swings and some types of depression
steroid medicines such as cortisone, prednisone
insulin and tablets used to treat diabetes
barbiturates, used to treat epilepsy, such as phenobarbitone
strong pain killers such as codeine, morphine, dextropropoxyphene
cholestyramine and colestipol, used to treat high cholesterol
medicines used to relax muscles before and during surgery
medicines used in emergency situations such as adrenaline
These medicines may be affected by ACCURETIC, or may affect how well it works. You may need different amounts of your medicine,
or you may need to take different medicines. Your doctor will advise you.
Tell your doctor if you are taking any of the following medicines:
mTOR inhibitors (e.g. temsirolimus), used in the treatment of kidney cancer
DPP-IV inhibitors (e.g. vildagliptin), used in the treatment of diabetes.
Taking ACCURETIC in combination with these medicines may increase your risk of having an allergic reaction.
If you are not sure if you are taking any of the medicines mentioned in this leaflet, check with your doctor or pharmacist.
Your doctor and pharmacist may have more information on medicines to be careful with or avoid while taking ACCURETIC.
Use in children
The safety and effectiveness of ACCURETIC in children has not been established.
How to take ACCURETIC
Follow all directions given to you by your doctor or pharmacist carefully.
They may differ from the information contained in this leaflet.
Your doctor or pharmacist will tell you which ACCURETIC tablet you will need to take each day. This depends on your condition
and whether or not you are taking any other medicines.
If you do not understand the instructions on the box, ask your doctor or pharmacist for help.
How much to take
For most patients, the usual starting dose of ACCURETIC is 10/12.5 mg a day. The dose may need to be increased to one ACCURETIC
20/12.5 tablet a day, then two ACCURETIC 10/12.5 tablets a day if necessary. Most patients take between 10/12.5 to 20/12.5
mg daily. Each dose may be taken once a day.
How to take it
Swallow ACCURETIC whole with a full glass of water.
Do not chew the tablets.
When to take it
Take ACCURETIC at about the same time each day, with or without food.
Taking your tablets at the same time each day will have the best effect. It will also help you remember when to take the
tablets. It does not matter whether you take it with or without food.
How long to take it
ACCURETIC helps control your condition, but does not cure it. Therefore you must take ACCURETIC every day. Continue taking
your medicine for as long as your doctor tells you.
If you forget to take it
If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.
Otherwise, take it as soon as you remember and then go back to taking your medicine as you would normally.
Do not take a double dose to make up for the dose that you missed.
This may increase the chance of you getting an unwanted side effect.
If you are not sure what to do, ask your doctor or pharmacist.
If you have trouble remembering to take your medicine, ask your pharmacist for some hints.
If you take too much (overdose)
Immediately telephone your doctor or the Australian Poisons Information Centre (telephone 13 11 26) or the New Zealand National
Poisons Information Centre (telephone 0800 POISON or 0800 764 766), or go to Accident and Emergency at the nearest hospital,
if you think that you or anyone else may have taken too much ACCURETIC. Do this even if there are no signs of discomfort
Keep telephone numbers for these places handy.
If you take too much ACCURETIC, you may feel light-headed, dizzy or you may faint. You may also become thirsty, confused,
have a change in the amount of urine passed or have a fast heart beat.
While you are taking ACCURETIC
Things you must do
If you are about to be started on any new medicine, tell your doctor, dentist or pharmacist that you are taking ACCURETIC.
Make sure you drink enough water during exercise and hot weather when you are taking ACCURETIC, especially if you sweat a
If you do not drink enough water while taking ACCURETIC, you may feel faint, light-headed or sick. This is because your blood
pressure is dropping suddenly. If you continue to feel unwell, tell your doctor.
If you have excess vomiting and/or diarrhoea while taking ACCURETIC, or you have any of the following symptoms, tell your
dry mouth, thirst
weakness, tiredness, drowsiness
muscle pains or cramps
fast heart beat
passing less urine than normal.
You may be dehydrated because you are losing too much water.
If you feel light-headed or dizzy after taking your first dose of ACCURETIC, or when your dose is increased, tell your doctor
If you plan to have surgery that needs a general anaesthetic, tell your doctor or dentist that you are taking ACCURETIC.
Your blood pressure may drop suddenly.
If you become pregnant while taking ACCURETIC, tell your doctor immediately.
If you are about to have any blood tests, tell your doctor that you are taking ACCURETIC.
ACCURETIC may interfere with the results of some tests.
Have your blood pressure checked when your doctor says, to make sure ACCURETIC is working.
Go to your doctor regularly for a check-up.
Your doctor may occasionally do a blood test to check your potassium levels and see how your kidneys are working.
Things you must not do
Do not give ACCURETIC to anyone else, even if they have the same condition as you.
Do not take ACCURETIC to treat any other complaints unless your doctor or pharmacist tells you to.
Do not stop taking ACCURETIC, or lower the dosage, without checking with your doctor.
Things to be careful of
If you feel light-headed, dizzy or faint when getting out of bed or standing up, get up slowly.
Standing up slowly, especially when you get up from bed or chairs, will help your body get used to the change in position
and blood pressure. If this problem continues or gets worse, talk to your doctor.
Be careful driving or operating machinery until you know how ACCURETIC affects you.
As with other medicines in this class, ACCURETIC may cause dizziness, light-headedness or tiredness in some people. Make
sure you know how you react to ACCURETIC before you drive a car, operate machinery, or do anything else that could be dangerous
if you are dizzy or light-headed. If this occurs do not drive. If you drink alcohol, dizziness or light-headedness may be
Things that would be helpful for your blood pressure
Some self help measures suggested below may help your condition. Talk to your doctor or pharmacist about these measures and
for more information.
your doctor may advise you to limit your alcohol intake.
your doctor may suggest losing some weight to help lower your blood pressure and help lessen the amount of work your heart
has to do. Some people may need a dietician's help to lose weight.
eat a healthy diet which includes plenty of fresh vegetables, fruit, bread (preferably wholegrain), cereals and fish. Also
eat less sugar and fat (especially saturated fat) which includes sausages, fatty meats, full cream dairy products, biscuits,
cakes, pastries, chocolates, chips and coconut. Monounsaturated and polyunsaturated fats from olive oil, canola oil, avocado
and nuts are beneficial in small quantities.
your doctor may advise you to watch the amount of salt in your diet. To reduce your salt intake you should avoid using salt
in cooking or at the table and avoid cooked or processed foods containing high sodium (salt) levels.
regular exercise, maintained over the long term, helps to reduce blood pressure and helps get the heart fitter. Regular exercise
also improves your blood cholesterol levels, helps reduce your weight and stress levels, and improves your sleep, mood and
ability to concentrate. However, it is important not to overdo it. Before starting any exercise, ask your doctor about the
best kind of programme for you.
your doctor may advise you to stop smoking or at least cut down. Ask your doctor or pharmacist for further information and
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking ACCURETIC.
ACCURETIC helps most people with high blood pressure, but it may have unwanted side effects in a few people. All medicines
can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you
get some of the side effects.
If you are over 65 years of age you may have an increased chance of getting side effects.
Ask your doctor or pharmacist to answer any questions you may have.
Following is a list of possible side effects. Do not be alarmed by this list. You may not experience any of them.
Tell your doctor or pharmacist if you notice any of the following and they worry you:
feeling light-headed, dizzy or faint
feeling sick (nausea) or vomiting
aching, tender or weak joints or muscles not caused by exercise
unusual tiredness or weakness, fatigue
sleepiness or drowsiness
difficulty in getting or maintaining an erection (impotence)
runny or blocked nose, or sneezing
taste disturbances or loss of taste
confusion or nervousness
sore throat and discomfort when swallowing
blurred vision or yellow vision.
These side effects are usually mild.
Tell your doctor as soon as possible if you notice any of the following:
itchy or raised skin rash, hives or nettle rash
symptoms of sunburn (such as redness, itching, swelling, blistering) which may occur more quickly than normal
signs of anaemia such as tiredness, being short of breath and looking pale
fast or irregular heart beat
shortness of breath or tightness in the chest
tingling or numbness in the hands, feet or ankles
severe upper stomach pain, often with nausea and vomiting
signs of worrying or frequent infections such as fever, severe chills, sore throat or mouth ulcers
passing little or no urine
swelling of the hands, feet or ankles
bleeding or bruising more easily than normal
yellowing of the skin and/or eyes.
These may be serious side effects. You may need medical attention. Serious side effects are rare.
If any of the following happen, stop taking ACCURETIC and either tell your doctor immediately or go to Accident and Emergency
at your nearest hospital:
fainting within a few hours of taking a dose
collapse, numbness or weakness in the arms or legs
swelling of the face, lips, mouth, tongue or throat which may cause difficulty in swallowing or breathing
sudden onset of stomach pains or cramps with or without nausea or vomiting
pink or red itchy spots on the skin which may blister and progress to form raised, red, pale-centred marks
severe flaking or peeling of the skin
severe blisters and bleeding in the lips, eyes, mouth, nose and genitals
severe skin reaction which starts with painful red areas, then large blisters and ends with peeling of layers of skin. This
may be accompanied by fever and chills, aching muscles and generally feeling unwell
loss of vision; may be temporary or more gradual.
These are very serious side effects. You may need urgent medical attention or hospitalisation. These side effects are very
Other side effects not listed above may occur in some patients. Tell your doctor or pharmacist if you notice anything that
is making you feel unwell.
After taking ACCURETIC
Keep your tablets in the box until it is time to take them.
If you take the tablets out of the box they will not keep well.
Keep your tablets in a cool dry place where the temperature stays below 25°C.
Do not store ACCURETIC or any other medicine in the bathroom or near a sink.
Do not leave it on a windowsill or in the car on hot days.
Heat and dampness can destroy some medicines.
Keep it where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
If your doctor or pharmacist tells you to stop taking ACCURETIC or the tablets have passed their expiry date, ask your pharmacist
what to do with any that are left over.
What it looks like
ACCURETIC tablets come in two strengths and each has a different appearance:
ACCURETIC 10/12.5 - Pink, oval, biconvex, film-coated tablets, scored on both sides
ACCURETIC 20/12.5 - Pink, triangular, biconvex, film-coated tablets, scored on one side
A box of ACCURETIC contains 30 tablets.
ACCURETIC 10/12.5 - 10 mg quinapril hydrochloride and 12.5 mg hydrochlorothiazide per tablet
ACCURETIC 20/12.5 - 20 mg quinapril hydrochloride and 12.5 mg hydrochlorothiazide per tablet
Opadry Pink OY-S-6937.
ACCURETIC does not contain sucrose, gluten, tartrazine or any other azo dyes.
ACCURETIC is supplied in Australia by:
Pfizer Australia Pty Ltd
ABN 50 008 422 348
38-42 Wharf Road
West Ryde NSW 2114
Toll Free Number: 1800 675 229
ACCURETIC is supplied in
New Zealand by:
Pfizer New Zealand Ltd
PO Box 3998
Toll Free Number: 0800 736 363
Australian Registration Numbers
ACCURETIC 10/12.5 - AUST R 81930
ACCURETIC 20/12.5 - AUST R 81931
This leaflet was prepared in April 2013.
© Pfizer Australia Pty Ltd 2013.
®Registered Trade Mark