Palonosetron 250 mcg per 5 mL solution for injection
Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about ALOXI. It does not contain all the available information. It does not take
the place of talking to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits it
is expected to have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet.
You may need to read it again.
What ALOXI is used for
This medicine belongs to a group of medicines known as serotonin (5-HT3) antagonists and is a colourless solution for injection
into a vein.
It is used for the prevention of nausea and vomiting associated with cancer chemotherapy.
Ask your doctor if you have any questions about why this medicine has been prescribed for you.
Your doctor may have prescribed this medicine for another purpose.
Before you are given ALOXI
When you must not be given it
Do not use this medicine if you have an allergy to:
any of the ingredients listed at the end of this leaflet.
Some of the symptoms of an allergic reaction may include:
shortness of breath
wheezing or difficulty breathing or a tight feeling in your chest
swelling of the face, lips, tongue or other parts of the body
rash, itching or hives on the skin
ALOXI should not be used to prevent or treat nausea and vomiting in the days following chemotherapy if not associated with
another chemotherapy administration.
Before you are given it
You doctor must know about all of the following before you are given this medicine.
Tell your doctor or pharmacist if you have allergies to medicines or any other medicines, foods, preservatives or dyes.
Tell your doctor if you are pregnant or think you might be.
Your doctor will not use this medicine unless it is clearly necessary as it is not known whether it will cause any harmful
effects when used during pregnancy. You should always ask your doctor or pharmacist for advice before using any medicine if
you are pregnant or think you might be.
Tell your doctor if you are breast-feeding.
It is not known if this medicine is found in breast milk. You should ask your doctor or pharmacist for advice before using
it if you are breast-feeding.
If you have not told your doctor about any of the above, tell him/her before you are given this medicine.
Taking or being given other medicines
Tell your doctor if you are taking any other medicines, including any that you get without a prescription from your pharmacy,
supermarket or health food shop.
Some medicines may affect the way other medicines work. Your doctor or pharmacist will be able to tell you what to do when
being given this medicine with other medicines.
How ALOXI is given
This medicine is given as an injection into a vein. A doctor or nurse will normally inject it about 30 minutes before the
start of chemotherapy.
Your doctor will decide how much of this medicine you will be given and for how long.
If you take too much (overdose)
As this medicine is given to you under the supervision of your doctor, it is very unlikely that you will receive too much.
However, if you experience any side effects after being given it, tell your doctor immediately.
While you are using ALOXI
Things you must do
If the medicine starts to upset you and your symptoms become worse, tell your doctor.
Tell any other doctors, dentists, and pharmacists who are treating you that you are being treated with this medicine.
Tell your doctor if you become pregnant during treatment with this medicine.
Things to be careful of
It is not known if this medicine has any effect on your ability to drive or use machines. You should be certain that you are
able to drive and operate machines before you try.
Tell your doctor, nurse or pharmacist as soon as possible if you do not feel well while you are being given this medicine.
All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical attention
if you get some of the side effects.
Do not be alarmed by the following lists of side effects. You may not experience any of them.
Ask your doctor or pharmacist to answer any questions you may have.
The following common side effects may occur.
Tell your doctor, nurse or pharmacist if you notice any of the following and they worry you:
The following uncommon side effects may also occur.
Loss of appetite
Anxiety or euphoria
Change of sensation in your limbs
Visual or hearing disturbances
Change in heart rate
Prominent or discoloured veins
Hiccups, flatulence or dry mouth
Upset stomach or stomach pains
Difficulty passing water
Weakness or tiredness
Fever or a flu-like illness
The above list includes the more common side effects of your medicine. They are usually mild and short-lived.
You should tell your doctor if you notice any of the above effects.
Your doctor will tell you if the following uncommon side effects occur.
changes in the amounts of certain substances in your blood or urine
changes in your blood pressure
Other side effects not listed above may also occur in some people.
Tell your doctor if you notice any other effects.
After receiving ALOXI
Store in the original container. Keep the container in the outer carton in order to protect from light.
Keep in a cool dry place where the temperature stays below 25°C.
Keep out of the reach and sight of children.
Do not use this medicine if the expiry date printed on the pack has passed.
What it looks like
This medicine is a colourless solution. It is supplied in a pack of one glass vial, which contains 5 mL of the solution. Each
vial contains enough for one dose.
ALOXI contains 250 mcg of Palonosetron (as the hydrochloride) as the active ingredient.
Citric acid monohydrate
Water for injections
ALOXI is supplied in Australia by:
Mundipharma Pty Limited
88 Phillip Street
Sydney NSW 2000
In New Zealand:
Mundipharma New Zealand Limited
C/Pharmaco (NZ) Limited
Auckland, NEW ZEALAND
This leaflet was prepared in April 2016.
Australian Registration Number
ALOXI 250 mcg per 5 mL injection
AUST R 114185
® ALOXI is a registered trade mark of Helsinn Healthcare SA, Switzerland.