Alprostadil, Prostaglandin E1 (PGE1) 10 and 20 micrograms
Consumer Medicine Information
NOTICE: This Consumer Medicine Information (CMI) is intended for persons
living in Australia. This page contains answers to some common
. It does
not contain all the information that is known about
. It does not take the
place of talking to your doctor or pharmacist. All medicines have risks
and benefits. Your doctor has weighed the risk of you using this medicine
against the benefits he/she expects it will have for you. If you have
any concerns about using this medicine, ask your doctor or pharmacist.
Bookmark or print this page, you may need to read it again.
What CAVERJECT is used for
What CAVERJECT does
CAVERJECT may be prescribed by your doctor for the treatment of erectile dysfunction (inability to maintain an erection to
have sexual intercourse).
CAVERJECT may also be used to help in the diagnosis of erectile dysfunction.
CAVERJECT contains alprostadil. Alprostadil is also known as prostaglandin E1 (PGE1) and is found naturally in many parts
of your body.
How CAVERJECT works
CAVERJECT works by increasing the blood flow to the penis. The increased blood flowing into the penis is trapped in the spongy
erectile tissue of the penis called the corpora cavernosa. When these chambers fill with blood they swell and your penis becomes
CAVERJECT is injected into a specific area of the penis and should produce an erection in 5 to 20 minutes. The erection should
last for about 30 to 60 minutes.
Ask your doctor if you have any questions about why this medicine has been prescribed for you.
Your doctor may have prescribed CAVERJECT for another reason.
This medicine is available only with a doctor's prescription.
Before you are given CAVERJECT
When you must not use it
Do not use CAVERJECT if you have an allergy to:
any medicine containing alprostadil
any of the ingredients listed at the end of this leaflet.
Some of the symptoms of an allergic reaction may include:
shortness of breath
wheezing or difficulty breathing
swelling of the face, lips, tongue or other parts of the body
rash, itching or hives on the skin.
Do not use CAVERJECT if you have or have had any of the following medical conditions:
a penis which is scarred or not straight
you have painful erections (Peyronie's disease)
a penile implant
certain illnesses such as leukaemia, multiple myeloma, sickle cell anaemia or any other condition which causes your erection
to last for a long time (Priapism)
abnormal thickening of the tissues of your penis
been advised not to have sex.
Do not give this medicine to women.
Do not give CAVERJECT to children or newborns.
Do not use this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.
If it has expired or is damaged, return it to your pharmacist for disposal.
If you are not sure whether you should use this medicine, talk to your doctor.
Before you start to use it
Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes.
Tell your doctor or your partner's obstetrician if your partner intends to become pregnant.
If you have not told your doctor about any of the above, tell him/her before you start taking CAVERJECT.
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including:
all prescription medicines
all medicines, vitamins, herbal supplements or natural therapies you buy without a prescription from a pharmacy, supermarket,
naturopath or health food shop.
Some medicines may be affected by CAVERJECT or may affect how well it works. You may need different amounts of your medicines,
or you may need to use different medicines. Your doctor will advise you.
Tell your doctor or pharmacist if you are taking any of the following:
medicine used to prevent blood clots, e.g., warfarin or heparin.
Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine.
The use of CAVERJECT offers no protection from sexually transmitted diseases or those caused by the human immunodeficiency
virus (HIV) such as AIDS. Your doctor can give you more information about the type of protection you should use against these
You may also need to consider using appropriate contraception.
The injection of CAVERJECT can cause a small amount of bleeding at the site of injection. If you have any diseases that can
be passed by blood, e.g., hepatitis B, there could be a higher chance of passing them onto your partner.
How to use CAVERJECT
CAVERJECT is a single use device. The syringe device should only be used to administer one dose and then discarded.
Follow all directions given to you by your doctor or pharmacist carefully.
They may differ from the information contained in this leaflet.
If you do not understand the instructions provided at the end of this leaflet, ask your doctor or pharmacist for help.
How much to use
Your doctor will tell you how much CAVERJECT to use. This depends on your condition and whether or not you are taking any
You should use CAVERJECT no more than once in a 24 hour period and not more than three times a week.
You should not use more than 3 vials for any one treatment.
You should not change your dosage without first talking to your doctor.
How long to use it
Continue using your medicine for as long as your doctor tells you.
This medicine helps to control your condition, but does not cure it.
If you use too much (overdose)
Remember to only use the amount of CAVERJECT that your doctor told you to use. If you use more CAVERJECT than your doctor
has prescribed, your erection may last longer than is medically safe and may require medical intervention. You should contact
your doctor if your erection lasts for more than four (4) hours.
Immediately telephone your doctor, or Poisons Information Centre (telephone Australia 13 11 26 or New Zealand 0800 POISON
or 0800 764 766) for advice, or go to Accident and Emergency at the nearest hospital, if you think that you or anyone else
may have used too much CAVERJECT
Do this even if there are no signs of discomfort or poisoning.
You may need urgent medical attention.
While you are using CAVERJECT
Things you must do
If you are about to be started on any new medicine, remind your doctor and pharmacist that you are using CAVERJECT.
Tell any other doctors, dentists, and pharmacists who treat you that you are taking this medicine.
If you are going to have surgery, tell the surgeon or anaesthetist that you are taking this medicine.
It may affect other medicines used during surgery.
If your partner becomes pregnant while you are using CAVERJECT, tell your doctor or your partner's obstetrician.
If you are about to have any blood tests, tell your doctor that you are using this medicine.
It may interfere with the results of some tests.
If you are being treated with warfarin or heparin (medicines that are used to stop your blood from clotting) you need to be
aware of an increased chance of bleeding after injection.
An injection with CAVERJECT should produce an erection that lasts for 30 - 60 minutes and enables you to have sex.
Tell your doctor if your erection lasts for more than 60 minutes. Your dose may need to be reduced.
Keep all of your doctor's appointments so that your progress can be checked.
From time to time your doctor will need to examine the injection site to detect any abnormal thickening of the tissues of
the penis. If this happens, your treatment with CAVERJECT will be stopped.
Always discuss with your doctor any problems or difficulties during or after using CAVERJECT.
Things you must not do
Do not use CAVERJECT to treat any other complaints unless your doctor tells you to.
Do not give your medicine to anyone else, even if they have the same condition as you.
Do not stop using your medicine or lower the dosage without checking with your doctor.
Do not use any mixture left in the syringe or vial for a second injection.
Do not use the needle to inject if it is bent (refer to notes under the subheading "How to prepare the injection").
Check with your doctor as soon as possible if you have any problems while using CAVERJECT, even if you do not think the problems
are connected with the medicine or are not listed in this leaflet.
Like many medicines, CAVERJECT may cause side effects. If they occur, they are likely to be minor and temporary. However,
some may be serious and need medical attention.
Ask your doctor or pharmacist to answer any questions you may have.
These are common side effects of CAVERJECT. Mostly these are mild and short lived:
pain in the penis during erection
bruising at the site of injection.
Tell your doctor if you experience the following uncommon or rare side effects:
redness, swelling, bleeding and itching at the site of injection
localised pain (buttocks, leg, genital, back or pelvis)
increased feeling of pain or sensitivity, especially in the skin
inflammation of the head of the penis
hardened areas developing at the site of injection. This can result in curvature of the penis
prolonged erection (lasting 4 to 6 hours). See below.
abnormal ejaculation or painful erection
swelling, redness, pain of the scrotum
disorder of the testis (pain, warmth, swelling, thickening)
changes in your heartbeat or palpitations
changes in blood pressure
dizziness and headache
nausea, dry mouth
the desire to pass urine more frequently than normal or difficulty in urinating. If CAVERJECT is injected by mistake into
the tube which carries urine out through the penis (urethra), some blood may appear in the urine or at the end of the penis
skin rash, redness, sensitivity, irritation, itchiness
Your doctor will check regularly that CAVERJECT is not causing abnormal thickening of the tissues of the penis. If this happens,
your treatment with CAVERJECT will be stopped.
If your erection lasts for more than 1 hour, you should tell your doctor as your dose may need to be reduced.
If your erection lasts for more than 2 hours, try walking around, especially up and down stairs, emptying your bladder, or
taking a hot or cold shower. You should avoid any further sexual activity.
Contact your doctor immediately if your erection lasts for 4 hours or more. This can be painful and may require medical treatment.
Other side effects not listed above may occur in some patients.
Tell your doctor or pharmacist if you notice anything that is making you feel unwell.
Do not be alarmed by this list of possible side effects.
You may not experience any of them.
Ask your doctor or pharmacist to answer any questions you may have.
After using CAVERJECT
Keep your unused packs of CAVERJECT vials in a cool dry place where the temperature stays below 25°C. Do not freeze. After
dissolving the CAVERJECT powder, the solution of CAVERJECT should be used as soon as possible. If storage is necessary, store
at 2-8°C (Refrigerate. Do not freeze.) for not more than 24 hours after dissolving.
Care should be taken to avoid storing the product at temperatures above 25°C even when you travel.
Do not store CAVERJECT in checked luggage during air travel.
Do not store CAVERJECT or any other medicine in the bathroom or near a sink. Do not leave it on a window sill or in the car.
Heat and dampness can destroy some medicines.
Keep it where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
After using CAVERJECT, put all the injection material back into its original box and ask your pharmacist to dispose them safely.
If your doctor tells you to stop using this medicine or the expiry date has passed, ask your pharmacist what to do with any
medicine that is left over.
What it looks like
CAVERJECT 10 micrograms or CAVERJECT 20 micrograms is available as a sterile freeze-dried powder. It is supplied in a clear
glass vial. CAVERJECT is available in packs containing 1, 5 or 10.
*Not all pack sizes are marketed
CAVERJECT powder for injection contains either 10 micrograms or 20 micrograms of the active ingredient, alprostadil (prostaglandin
The other ingredients are lactose, alfadex, sodium citrate, hydrochloric acid, sodium hydroxide.
The diluent in CAVERJECT contains Water for Injections and benzyl alcohol.
This medicine does not contain sucrose, gluten, tartrazine or any other azo dyes.
CAVERJECT is supplied in Australia by:
Pfizer Australia Pty Ltd
ABN 50 008 422 348
38-42 Wharf Road
West Ryde NSW 2114
Toll Free number: 1800 675 229
It is supplied in New Zealand by:
Pfizer New Zealand Ltd
PO Box 3998
Auckland, New Zealand
Toll Free number: 0800 736 363.
Australian registration numbers
CAVERJECT 10 micrograms, AUST R 202518.
CAVERJECT 20 micrograms, AUST R 202519.
Date of preparation
This leaflet was prepared in August 2013.
® Registered trademark of Pfizer Inc.
© Pfizer Australia Pty Ltd 2013.
INSTRUCTIONS ON HOW TO USE CAVERJECT
You must be properly instructed and trained in the injection technique by your doctor before using CAVERJECT. It is important
that you follow your doctor's instructions at all times. If you are not certain about the way to prepare your CAVERJECT injection
please contact your doctor; this leaflet is only intended to remind you about the instructions that your doctor has already
PART I - Check your package content
Your pharmacist will give you a box containing:
a glass vial of CAVERJECT powder
a syringe filled with diluent (bacteriostatic Water for Injections)
two needles (a 22 gauge needle for adding diluent to dissolve the CAVERJECT powder and a 27 gauge needle or 30 gauge needle
two alcohol swabs.
Part II - Preparing the syringe for injection
Follow these instructions exactly to prepare and inject a sterile dose of CAVERJECT. If the needle is bent at any time, do
not use it for injecting CAVERJECT and do not attempt to straighten it prior to injecting CAVERJECT. A bent and restraightened
needle may be predisposed to breakage. Needle breakage with a portion of the needle remaining in the penis has been reported
and in some cases required hospitalisation and surgical removal.
Wash your hands thoroughly with soap and water.
Unpack the CAVERJECT packaging.
Prepare your vial and syringe just before application.
Preparing the vial
1. Flip the plastic cap off the vial. Wipe the rubbery top with one of the alcohol swabs. Discard this alcohol swab.
Fitting the needle
2. Hold the syringe and twist the white tamper evident cap to break the seal.
3. Take the foil off the larger needle, (22G) keeping its cover on. Join the needle to the syringe by turning the needle clockwise
tightly onto the syringe.
4. Remove the needle cover by pushing it away from the syringe with your thumb and forefinger. Do not touch the exposed needle.
Preparing the solution from the powder
5. Inject diluent into the vial by pressing the plunger down firmly to squirt all the diluent onto the powder. Push the needle
through the rubbery middle of the vial top.
6. Without removing the syringe from the vial gently shake the vial gently swirl the vial until all the powder has dissolved.
7. Do not use if it is cloudy, coloured or contains particles. Never use tap water or any liquid other than the supplied diluent.
Filling the syringe
8. With the needle still inserted, turn the vial upside down. Make sure the needle tip is underneath the level of the liquid.
9. Gently pull the plunger to draw all the solution into the syringe.
10. Hold the sides of the syringe (not the plunger) and remove the needle from the syringe by twisting it in an anticlockwise
direction. Do not pull the needle out of the vial. This needle stays in the vial.
11. Remove the smaller needle, (27G) from its package keeping the cover on.
12. Twist the needle clockwise tightly onto the syringe then remove the needle cover by pushing it away from the syringe with
your thumb and forefinger.
Setting the dose
13. If there are air bubbles, gently tap the sides of the syringe to allow them to float to the top of the solution then push
the plunger to squeeze the air bubbles out, ensuring that at least one drop of solution comes out of the needle.
14. Continue pushing until the plunger is exactly at the right mark for your dose. Your doctor will have shown you your correct
Part III - Injecting the prepared Caverject solution
The reconstituted CAVERJECT is injected into either of two sections of the penis called the corpora cavernosa. The corpora
cavernosa run the length of the shaft of the penis, one on either side.
Follow these instructions carefully before proceeding with your CAVERJECT injection.
DO NOT USE THE NEEDLE IF IT IS BENT.
Refer to notes under the subheading "Part II - How to prepare the injection").
1. Perform the self-injection procedure whilst sitting in an upright, slightly reclining or standing position.
2. Inject CAVERJECT only in the corpus cavernosum. Do not inject into any visible veins, the top or the underside of the penis.
3. Alternate the injection site each time you use CAVERJECT; choose one side of your penis for this injection, use the other
side next time and so on. Within each area, the actual point of injection should also be changed each time.
4. Hold the head of your penis with your thumb and forefinger and squeeze gently. The injection site will then bulge out. Stretch
your penis tightly against your thigh so that it does not slip during the procedure. If you are uncircumcised the foreskin
must be pulled back before you inject the solution.
5. Clean the injection area with an alcohol swab. Put the swab on one side.
Inserting the needle
6. Hold the syringe between your thumb and index finger. Do not press on the plunger. Gently rest needle on the penis. With a
steady, continuous motion, insert the entire length of the needle at a 90° angle into the injection site.
Injecting the contents of the syringe
7.Withdraw the needle from your penis. Apply pressure to the injection site for at least five minutes with the alcohol swab.
If bleeding occurs, maintain this pressure on the injection site until the bleeding stops.
8. After using the contents of this pack, dispose of all materials safely (see Disposal section). Do not reuse or share needles