400 mg tablets; 200 mg/5 mL granules; 400 mg/5 mL granules
erythromycin as ethyl succinate
Consumer Medicine Information
NOTICE: This Consumer Medicine Information (CMI) is intended for persons
living in Australia. This page contains answers to some common
. It does
not contain all the information that is known about
. It does not take the
place of talking to your doctor or pharmacist. All medicines have risks
and benefits. Your doctor has weighed the risk of you using this medicine
against the benefits he/she expects it will have for you. If you have
any concerns about using this medicine, ask your doctor or pharmacist.
Bookmark or print this page, you may need to read it again.
What EES is used for
EES is used to:
treat certain bacterial infections; these infections may occur in different parts of the body
prevent infections in patients with a history of rheumatic disease, congenital heart disease or other acquired valvular heart
disease and who may be allergic to penicillin antibiotics.
Your doctor, however, may have prescribed EES for another purpose.
Ask your doctor if you have any questions about why EES has been prescribed for you.
EES is an antibiotic that belongs to the group of medicines called macrolides. These medicines work by killing or stopping
the growth of bacteria, which cause infections or make acne worse.
EES will not work against infections caused by viruses, such as colds or flu.
EES is available only with a doctor's prescription.
Before you take EES
When you must not take it
Do not take EES if you have an allergy to:
any medicine containing erythromycin
any of the ingredients listed at the end of this leaflet
other antibiotics from the macrolide family, including:
Some of the symptoms of an allergic reaction may include:
shortness of breath
wheezing or difficulty breathing
swelling of the face, lips, tongue or other parts of the body
rash, itching or hives on the skin.
You must not take EES if:
you are taking
terfenadine or astemizole
cisapride, pimozide or domperidone
class IA and III antiarrhythmics e.g. quinidine, disopyramide, procainamide, amiodarone and sotalol
certain neuroleptics and tri- and tetracyclic antidepressants
arsenic trioxide, methadone, budipine, certain fluoroquinolones, imidazole anti-mycotics and anti-malarials e.g. petamidine
simvastatin, lovastatin or atorvastatin
ergotamine or dihydroergotamine
you have severe liver disease.
you have heart rhythm disorders from birth or have developed it
you have irregular heartbeat or severe chronic heart failure
you have deficiency of potassium and magnesium in blood
Do not take this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.
If it has expired or is damaged, return it to your pharmacist for disposal.
If you are not sure whether you should be given this medicine, talk to your doctor.
Before you start to take or are given EES
Tell your doctor if you have allergic to any other medicines, foods, dyes or preservatives
Tell your doctor if you have or have had any of the following medical conditions:
myasthenia gravis, a condition in which muscles become weak and tire easily.
Tell your doctor if you are pregnant or plan to become pregnant or are breastfeeding.
Your doctor can discuss with you the risks and benefits involved.
If you have not told your doctor or pharmacist about any of the above, tell them before you start taking or are given EES.
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including medicines you can buy without a prescription
from a pharmacy, supermarket or health food shop.
Some medicines may interfere with EES. These include:
medicines used to prevent blood clotting, such as warfarin, acenocoumarol
some medicines used for epilepsy such as phenytoin, carbamazepine, hexobarbital, phenobarbital and valproate
theophylline, a medicine used to treat asthma
diltiazem, verapamil, felodipine and mibefradil, medicines used to treat high blood pressure and certain heart conditions
digoxin, a medicine used to treat heart failure
omeprazole and cimetidine, used to prevent ulcers by reducing amount of acid produced in stomach
ciclosporin, used to prevent organ transplant rejection or to treat certain problems with the immune system
tacrolimus, used as an adjunct to kidney transplantation
triazolam, zopiclone and midazolam, used to treat sleeplessness
nefazodone and St. John's wort, medicines used to treat depression
alprazolam used to treat anxiety disorders
methylprednisolone, a corticosteroid
vinblastine, a medicine used to treat Hodgkin's Disease
sildenafil, used to treat erectile dysfunction in adult males
mizolastine and ebastine medicines used to treat allergies such as hay fever
ritonavir, used to treat infections in patients with advanced HIV infection
medicines used to treat fungal infections such as ketoconazole, itraconazole, fluconazole
rifabutin, rifampicin, clindamycin, lincomycin, chloramphenicol, streptomycin, colistin and bactericidal beta-lactam antibiotics
(e.g. penicillin, cephalosporin)
bromocriptine, used to treat various conditions including Parkinson's Disease
colchicine, used for pain relief in gout
alfentanil, a medicine used for pain relief during anaesthesia
cilostazol, a medicine used in the treatment of painful calves, due to poor blood flow to the muscles
diphenoxylate with atropine used to treat diarrhoea
opiates used as analgesics.
These medicines may be affected by EES or may affect how well it works. You may need different amounts of your medicines,
or you may need to take different medicines.
Your doctor or pharmacist have more information on medicines to be careful with or avoid while you are taking this medicine.
How to take EES
Follow all directions given to you by your doctor or pharmacist carefully.
This may differ from the information contained in this leaflet.
If you do not understand the instructions on the box/bottle, ask your doctor or pharmacist for help.
How much to take
The dose may be given two, three or four times a day. The usual adult dose is one EES 400 mg tablet every six hours or 5 mL
of the EES 400 mg/5 mL liquid every six hours or 10 mL twice a day.
For children the dose varies depending on their age, weight and how sick they are.
Your doctor will adjust the amount or frequency of your doses according to the infection being treated and the severity of
How to take EES
EES may be taken before or after meals.
Tablets: Swallow whole with a glass of water.
Granules: Add 77 mL of water in small volumes and shake vigorously. When reconstituted, the suspension should be refrigerated
(but not frozen) and used within ten days.
Always shake the bottle well before each dose of EES granules.
Always use a medicine measure to give the exact dose of liquid medicines.
How long to take EES for
Keep taking EES until you finish the pack or bottle, or for as long as your doctor tells you.
If you are being treated for an infection, EES is usually taken for one or two weeks.
Do not stop taking EES, even if you feel better after a few days, unless advised by your doctor.
Your infection may not clear completely if you stop taking your medicine too soon.
For controlling acne, EES is normally taken for a few months.
Check with your doctor if you are not sure how long you should be taking EES.
If you forget to take EES
If it is almost time for you to take your next dose, skip the dose you missed and take your next dose when you are meant to.
Otherwise, take it as soon as you remember, and continue taking your medicine as you would normally.
Do not take a double dose to make up for the dose you missed.
If you miss more than one dose, or are not sure what to do, check with your doctor or pharmacist.
If you have trouble remembering to take your medicine, ask your pharmacist for some hints.
If you take too much EES (overdose)
Immediately telephone your doctor or Poisons Information Centre (telephone 13 11 26) for advice, or go to Accident and Emergency
at your nearest hospital if you think that you or anyone else may have taken too much EES. Do this even if there are no signs
of discomfort or poisoning.
You may need urgent medical attention.
Keep telephone numbers for these places/services handy.
If you take too much EES, you may have nausea, vomiting, hearing problems or allergic reactions.
While you are taking EES
Things you must do
If you are taking EES for an infection and your symptoms do not improve within a few days, or if they become worse, tell your
If you are about to start taking a new medicine, tell your doctor or pharmacist that you are taking EES.
Tell any other doctors, dentists and pharmacists who are treating you that you are taking EES.
If you are going to have surgery, tell the surgeon or anaesthetist that you are being given this medicine.
It may affect other medicines used during surgery.
If you become pregnant while taking EES, tell your doctor immediately.
If you get severe diarrhoea, tell your doctor or pharmacist immediately.
Do this even if it occurs several weeks after stopping EES. Diarrhoea may mean that you have a serious condition affecting
your bowel. You may need urgent medical care. Do not take any strong painkillers or any medicine to stop your diarrhoea without
first checking with your doctor.
If you have to have any blood tests, tell your doctor you are taking EES.
It may affect the results of some laboratory tests.
Things you must not do
Do not use EES to treat any other complaints unless your doctor says so.
Do not give this medicine to anyone else, even if their symptoms seem similar to yours.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking EES.
EES treats infections and controls acne in most people, but it may have unwanted side effects in a few people.
All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical attention
if you get some of the side effects.
Do not be alarmed by the following list of side effects. You may not experience any of them.
Ask your doctor or pharmacist to answer any questions you may have.
While you are taking EES
Tell your doctor if you experience any of the following:
stomach cramps and pains
nausea, vomiting, accumulation of gas and severe diarrhoea
These side effects are usually mild.
Tell your doctor immediately if you notice any of the following:
yellowing of the eyes or skin (jaundice)
generally feeling unwell and having poor appetite
loss of hearing
ringing or buzzing in the ears
fast, irregular or pounding heart beat
muscle pain, weakness and joint swelling
dizziness, drowsiness, confusion, hallucinations, fits
any type of skin rash, itching, hives
severe diarrhoea especially if bloody.
any vision problem
The above list contains serious side effects that may require medical attention. Serious side effects are rare.
Stop taking EES and tell your doctor immediately or go to Accident and Emergency at your nearest hospital if you notice:
serious allergic reaction (shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue or other
parts of the body; rash, itching or hives on the skin).
This is a very serious side effect. You may need urgent medical attention or hospitalisation. This side effect is very rare.
Some side effects can only be found if your doctor does tests on your blood or urine.
Tell your doctor or pharmacist if you notice anything else that is making you feel unwell.
Other side effects not listed above may also occur in some people.
After you have finished taking EES
Tell your doctor immediately if you notice any of the following side effects, even if they occur several weeks after stopping
treatment with EES:
severe stomach or abdominal cramps
watery and severe diarrhoea, which may also be bloody
fever, in combination with one or both of the above.
These are rare but serious side effects. You may have a serious condition affecting your bowel and you may need urgent medical
Do not take any diarrhoea medicine without first checking with your doctor.
This is not a complete list of all possible side effects. Others may occur in some people and there may be some side effects
not yet known.
Tell your doctor if you notice anything that is making you feel unwell while you are taking, or soon after you have finished
taking EES, even if it is not on this list.
After using EES
Keep your tablets/granules in the bottle until it is time to take them.
If you take the tablets/granules out of the bottle they may not keep well.
Keep EES tablets in a cool dry place where the temperature stays below 30°C.
Keep EES granules in the refrigerator but not in the freezer. Do not use any oral liquid left in the bottle after 10 days.
Do not keep EES or any other medicine in the bathroom or near a sink. Do not leave it in the car or on window sills.
Heat and dampness can destroy some medicines.
Keep your medicine where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
If your doctor tells you to stop taking EES, or your medicine has passed its expiry date, ask your pharmacist what to do with
any medicine that is left over.
What it looks like
EES is available as tablets or granules.
EES tablets are film coated pink tablets.
Each bottle contains 25 tablets.
EES granules are available in two strengths:
EES granules 200 mg/5 mL and EES granules 400 mg/5 mL.
After mixing with water, the granules become a thick pink liquid.
Supplied in a 100 mL white plastic bottle.
The active ingredient in EES tablets and granules is erythromycin (as erythromycin ethyl succinate).
Each EES tablet contains 400 mg of erythromycin as erythromycin ethyl succinate.
The tablets also contain:
Sucrose, sodium citrate, maize starch, polacrilin potassium, magnesium stearate, hypromellose, hydroxypropylcellulose, propylene
glycol, macrogol 400, sorbic acid, macrogol 8000.
Colours - allura red AC (129), brilliant scarlet 4R (124), indigo carmine (132) and sunset yellow FCF (110), titanium dioxide
EES tablets do not contain lactose or gluten.
EES granules 200 mg/5 mL
Each 5 mL of EES 200 mg/5 mL granules contains 200 mg erythromycin as erythromycin ethyl succinate.
EES granules 200 mg/5 mL also contain:
Carmellose sodium, sodium citrate, aluminium magnesium silicate.
Colour - erythrosine CI145430.
Flavour - cherry imitation.
Sweetener - sucrose, saccharin sodium.
EES granules 400 mg/5 mL
Each 5 mL of EES 400 mg/5 mL granules contains 400 mg erythromycin as erythromycin ethyl succinate.
EES 400 mg/5 mL granules also contain:
Carmellose sodium, sodium citrate, aluminium magnesium silicate, citric acid anhydrous.
Colour - carmoisine CI14720.
Flavour - cherry imitation.
Sweeteners - sucrose, saccharin sodium, sodium cyclamate.
EES granules 200 mg/5 mL and EES granules 400 mg/5 mL do not contain lactose or gluten.
EES tablets and granules are supplied in Australia by:
Amdipharm Mercury (Australia) Pty Ltd
Level 1, 134 Willoughby Road
Crows Nest NSW 2065
Australian Registration Numbers:
EES 400 mg tablets
AUST R 59205
EES 200 mg/5 mL granules
AUST R 173634
EES 400 mg/5 mL granules
AUST R 54456
Date of preparation
18 October 2016
Amdipharm Mercury (Australia) Pty Ltd is licensed to use the trademark E.E.S.