Contains the active ingredient, enalapril maleate
Consumer Medicine Information
NOTICE: This Consumer Medicine Information (CMI) is intended for persons
living in Australia. This page contains answers to some common
. It does
not contain all the information that is known about
. It does not take the
place of talking to your doctor or pharmacist. All medicines have risks
and benefits. Your doctor has weighed the risk of you using this medicine
against the benefits he/she expects it will have for you. If you have
any concerns about using this medicine, ask your doctor or pharmacist.
Bookmark or print this page, you may need to read it again.
What this medicine is used for
The name of your medicine is GenRx Enalapril. It contains the active ingredient enalapril.
It is used to treat:
high blood pressure
Both of these are long term (chronic) diseases so it is important that you continue to take your medicine every day.
High blood pressure (hypertension):
Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different
at different times of the day, depending on how busy or worried you are.
You have hypertension (high blood pressure) when your blood pressure stays higher than is needed, even when you are calm and
There are usually no symptoms of hypertension. The only way of knowing that you have hypertension is to have your blood pressure
checked on a regular basis.
If high blood pressure is not treated it can lead to serious health problems, including stroke, heart disease and kidney failure.
Heart failure means that the heart muscle is weak and cannot pump blood strongly enough to supply all the blood needed throughout
the body. Heart failure is not the same as heart attack and does not mean that the heart stops. Heart failure may start off
with no symptoms, but as the condition progresses, patients may feel short of breath or may get tired easily after light physical
activity such as walking. Some patients may wake up short of breath at night. Fluid may collect in different parts of the
body, often first noticed as swollen ankles and feet.
Your doctor may have prescribed enalapril for another reason.
Ask your doctor if you have any questions about why enalapril has been prescribed for you.
This medicine is only available with a doctor's prescription.
How it works
Enalapril belongs to a class of medicines known as Angiotensin Converting Enzyme (ACE) inhibitors. It works by widening your
blood vessels, reducing the pressure in the vessels (reducing 'blood pressure') and by making it easier for your heart to
pump blood around your body. This helps your heart to work better by increasing the supply of oxygen to your heart, so that
when you place extra demands on your heart, such as during exercise, your heart may cope better and you may not get short
of breath as easily.
This medicine is not addictive.
Use in children
There is not enough information to recommend the use of this medicine in children.
Before you take this medicine
When you must not take it
Do not take this medicine if:
You have a history of angioedema or angioneurotic oedema, which is swelling of the face, lips, tongue, throat (which may cause
difficulty in swallowing or breathing), hands or feet, for no apparent reason.
You are pregnant or trying to become pregnant.
Enalapril may cause serious injury to your developing baby if you take it during pregnancy.
You are hypersensitive to, or have had an allergic reaction to:
enalapril or any other medicine containing enalapril
any other ACE inhibitor, as you may be allergic to enalapril
lactose - this medicine contains lactose
any of the ingredients listed at the end of this leaflet.
Symptoms of an allergic reaction may include: cough, shortness of breath, wheezing or difficulty breathing; swelling of the
face, lips, tongue, throat or other parts of the body; rash, itching or hives on the skin; fainting; or hay fever-like symptoms.
If you think you are having an allergic reaction, do not take any more of the medicine and contact your doctor immediately
or go to the Accident and Emergency department at the nearest hospital.
The expiry date (EXP) printed on the pack has passed.
The packaging is torn, shows signs of tampering or it does not look quite right.
Before you start to take it
Before you start taking this medicine, tell your doctor if:
1. You have allergies to:
any other medicines
any other substances, such as foods, preservatives or dyes.
2. You have a family history of swelling of the face, lips, tongue, throat that may cause difficulty in swallowing or breathing.
3. You have or have had any medical conditions, especially the following:
systemic lupus erythematosus (SLE), scleroderma, any other autoimmune diseases or are taking any immunosuppressant medicine
kidney problems, or have had kidney problems in the past, or are having dialysis
liver problems, or have had liver problems in the past
any conditions in which you are taking diuretics (water tablets) and/or potassium containing medicines
are following a very low salt diet
are dehydrated, or have recently suffered from excessive vomiting or diarrhoea
are going to have surgery (including dental surgery) involving a general anaesthetic, even if it is minor
coughing when you have taken other ACE inhibitors in the past.
4. You are currently pregnant or you plan to become pregnant. Do not take this medicine whilst pregnant.
5. You are currently breastfeeding or you plan to breast-feed. Do not take this medicine whilst breastfeeding until you and your
doctor have discussed the risks and benefits involved.
6. You are planning to have surgery or an anaesthetic.
7. You are currently receiving or are planning to receive dental treatment.
8. You are taking or are planning to take any other medicines. This includes vitamins and supplements that are available from
your pharmacy, supermarket or health food shop.
Some medicines may interact with enalapril. These include:
water tablets or diuretics (for example Lasix®, Urex®, Natrilix®, Moduretic®)
potassium tablets (for example SPAN-K®, SLOW-K® or MAGK®)
potassium-containing salt substitutes (for example PRESSOR-K®)
lithium or lithium-containing preparations (for example Lithicarb®, Priadel®)
medicines used to treat diabetes
arthritis medicines, including gold therapy
anti-inflammatory medicines (these are used to relieve pain, swelling and other symptoms of inflammation, including arthritis)
and include non-steroidal anti-inflammatory agents - NSAIDS (for example Voltaren®, Indocid®) and COX-2 inhibitors (for example Celebrex®). Taking a combination of enalapril with a thiazide diuretic (water tablet) and an anti-inflammatory medicine may damage
If you are taking any of these you may need a different dose or you may need to take different medicines.
Other medicines not listed above may also interact with enalapril.
How to take this medicine
Follow carefully all directions given to you by your doctor. Their instructions may be different to the information in this
How much to take
Your doctor will tell you how much of this medicine you should take. This will depend on your condition and whether you are
taking any other medicines.
Do not stop taking your medicine or change your dosage without first checking with your doctor.
For High Blood Pressure (Hypertension):
For most patients, the usual starting dose is 5 mg taken once a day. Some patients may need a lower starting dose. Most patients
take between 10 mg to 40 mg each day. This dose may be taken once a day or divided into two doses per day.
For Heart Failure:
The usual starting dose is 2.5 mg taken once a day. Depending on your response, this dose may be increased up to 20 mg each
day. This dose may be taken once a day or divided into two doses per day.
How to take it
Swallow the tablets with a glass of water. Do not chew or crush the tablets.
When to take it
Take this medicine at the same time each day. Taking it at the same time each day will have the best effect and will also
help you remember when to take it.
It does not matter if you take it before, with or after food.
How long to take it for
Continue taking your medicine for as long as your doctor tells you.
This medicine helps to control your condition but does not cure it. It is important to keep taking your medicine every day,
even if you feel well.
Make sure you have enough to last over weekends and holidays.
If you forget to take it
If it is almost time to take your next dose, skip the missed dose and take your next dose at the usual time. Otherwise, take
it as soon as you remember and then go back to taking your medicine as you would normally.
Do not take a double dose to make up for missed doses.
This may increase the chance of you experiencing side effects.
If you have trouble remembering to take your medicine, ask your pharmacist for some hints to help you remember.
If you take too much (overdose)
If you think that you or anyone else may have taken too much of this medicine, immediately telephone your doctor or the Poisons
Information Centre (Tel: 13 11 26 in Australia) for advice. Alternatively, go to the Accident and Emergency department at
your nearest hospital.
Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.
While you are taking this medicine
Things you must do
If you become pregnant while taking this medicine, tell your doctor immediately.
Tell your doctor if you have excessive vomiting or diarrhoea or experience any of the following symptoms:
light-headed or dizzy
dry mouth or thirst
weakness, tiredness or drowsiness
muscle pain or cramps
fast heart beat
passing less urine than normal.
If you experience these symptoms, you may be dehydrated because you are losing too much water. This is more likely to occur
when you begin to take enalapril or if your dose is increased.
Make sure you drink enough water during exercise and hot weather when you are taking enalapril, especially if you sweat a
If you do not drink enough water while taking enalapril, your blood pressure may drop suddenly and you may dehydrate. If you
experience any of the above symptoms, tell your doctor.
Tell your doctor that you are taking this medicine if:
you are about to be started on any new medicine
you are breastfeeding or are planning to breast-feed
you are going to have surgery or an anaesthetic or are going into hospital.
Having a general anaesthetic while taking enalapril may cause your blood pressure to drop suddenly.
you are about to have any blood tests
Your doctor may occasionally do tests to make sure the medicine is working and to prevent side effects. Go to your doctor
regularly for a check-up.
Tell any other doctors, dentists and pharmacists who are treating you that you take this medicine.
Things you must not do
Give this medicine to anyone else, even if their symptoms seem similar to yours.
Take your medicine to treat any other condition unless your doctor tells you to.
Stop taking your medicine, or change the dosage, without first checking with your doctor.
Things to be careful of
As with other ACE inhibitor medicines, you may feel light-headed or dizzy when you begin to take enalapril or after your dose
is increased. This is because your blood pressure is dropping suddenly.
If you feel light-headed, dizzy or faint when getting out of bed or standing up, get up slowly.
Standing up slowly, especially when you get up from bed or chairs, will help your body get used to the change in position
and blood pressure. Be careful the first time you take enalapril, especially if you are elderly.
Be careful driving or operating machinery until you know how enalapril affects you.
As with other ACE inhibitor medicines, enalapril may cause dizziness or light-headedness in some people. Make sure you know
how you react to enalapril before you drive a car, operate machinery or do anything else that could be dangerous if you are
dizzy or light-headed. If this occurs do not drive
If you drink alcohol, dizziness or light-headedness may be worse.
Things that would be helpful for your blood pressure or heart failure
Some self-help measures suggested below may help your condition.
Talk to your doctor or pharmacist about these measures and for more information.
Your doctor may advise you to limit your alcohol intake.
Your doctor may suggest losing some weight to help lower your blood pressure and help lessen the amount of work your heart
has to do. Some people may need a dietician's help to lose weight.
Eat a healthy low-fat diet which includes plenty of fresh vegetables, fruit, bread, cereals and fish. Also eat less fat and
Your doctor may advise you to watch the amount of salt in your diet. To reduce your salt intake you should avoid using salt
in cooking or at the table.
Regular exercise helps to reduce blood pressure and helps to get the heart fitter, but it is important not to overdo it. Walking
is good exercise, but try to find a route that is reasonably flat. Before starting any exercise, ask your doctor about the
best kind of programme for you.
Your doctor may advise you to stop smoking or at least cut down.
Possible side effects
Tell your doctor as soon as possible if you do not feel well while you are taking enalapril or if you have any questions or
Do not be alarmed by the following lists of side effects. You may not experience any of them. All medicines can have side
effects. Sometimes they are serious but most of the time they are not.
Tell your doctor if you notice any of the following.
This list includes the more common side effects. Mostly, these are mild:
feeling light-headed, dizzy or faint
tiredness, fatigue or weakness
mild stomach upsets such as feeling sick (nausea), constipation or stomach pains
Tell your doctor as soon as possible if you notice any of the following.
These may be serious side effects and you may need medical attention. Mostly, these side effects are rare:
symptoms of sunburn (such as redness, itching, swelling, blistering) which may occur more quickly than normal
itchy skin rash or other skin problems
yellowing of the skin and/or eyes
fast or irregular heart beat
signs of worrying or frequent infections such as fever, severe chills, sore throat or mouth ulcers
passing less urine than is normal for you.
If you experience any of the following, stop taking your medicine and contact your doctor immediately or go to the Accident
and Emergency department at your nearest hospital.
These are very serious side effects and you may need urgent medical attention or hospitalisation. These side effects are usually
collapse, numbness or weakness in the arms or legs
pinkish, itchy swellings on the skin (hives, nettlerash)
swelling of the face, lips, mouth, tongue or throat, which may cause difficulty in swallowing or breathing
swelling of hands, feet or ankles
wheezing or difficulty in breathing
chest pain, angina.
Other side effects not listed above may occur in some patients.
If you think you are having an allergic reaction to enalapril, do not take any more of this medicine and tell your doctor
immediately or go to the Accident and Emergency department at your nearest hospital.
Symptoms of an allergic reaction may include some or all of the following:
cough, shortness of breath, wheezing or difficulty breathing
swelling of the face, lips, tongue, throat or other parts of the body
rash, itching or hives on the skin
hay fever-like symptoms.
Storage and disposal
Keep your medicine in its original packaging until it is time to take it.
If you take your medicine out of its original packaging it may not keep well.
Keep your medicine in a cool dry place where the temperature will stay below 25°C.
Do not store your medicine, or any other medicine, in the bathroom or near a sink. Do not leave it on a window sill or in
the car. Heat and dampness can destroy some medicines.
Keep this medicine where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
If your doctor tells you to stop taking this medicine or it has passed its expiry date, your pharmacist can dispose of the
remaining medicine safely.
What GenRx Enalapril looks like
GenRx Enalapril comes in three strengths:
5 mg - oval, convex, white snap tab tablets, with one side scored and marked EN 5.
10 mg - oval, convex, red-brown snap tab tablets, with one side scored and marked EN 10.
20 mg - oval, convex, orange snap tab tablets, with one side scored and marked EN 20.
All strengths are available in packs containing 30 tablets.
* Not all strengths, pack types and/or pack sizes may be available.
Each tablet contains enalapril as the active ingredient.
It also contains the following inactive ingredients:
Iron oxide yellow
Hydroxypropylcellulose (5 mg tablets only)
Iron oxide red (10 mg tablets only)
Iron oxide red (20mg tablets only)
This medicine is gluten-free, sucrose-free, tartrazine-free and free of other azo dyes.
Australian Registration Numbers
GenRx Enalapril 5mg Tablets (Blisters): AUST R 96330
GenRx Enalapril 10mg Tablets (Blisters): AUST R 96331
GenRx Enalapril 20mg Tablets (Blisters): AUST R 96332
Apotex Pty Ltd
16 Giffnock Avenue
Macquarie Park NSW 2113
GenRx is a registered trademark of Apotex Pty Ltd.
This leaflet was last updated in November 2012.