Kronisk træthed syndrom patofysiologi

Mekanismer og patogenese af kronisk træthed syndrom er ukendt. infektion ved virus og patogene bakterier, hypothalamic-hypofyse-adrenal akse abnormiteter, immun dysfunction samt psykologiske og psykosociale faktorer. Athough det er uklart, hvilke faktorer er årsag eller konsekvens af CFS, foreslås forskellige modeller.

En 2009 undersøgelse foreslår et link mellem retrovirus xenotropic murine leukemia virus-relaterede virus (XMRV) og kronisk træthed syndrom. Forskere identificeres DNA virus i blodet i 101 patienter (67%) 68 sammenlignet med 8 218 (3,7%) af sunde kontrolelementer og rapporterede evnen til at inficere cellekulturer in vitro med XMRV fra aktiverede celler eller plasma afledt CFS patienter. En forudgående påstand retrovirale foreninger med CFS blev efterfølgende negeret.

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