Combating viruses is often a frustrating business. Find a way to destroy them - and before you know it, they’ve found a way to defend themselves and neutralize the anti-viral treatment.
How, exactly, do the viruses do it? In an article published as the cover story in a recent issue of the journal Proteins, a Hebrew University of Jerusalem researcher, Prof. Isaiah (Shy) T. Arkin, has revealed just how influenza-causing viruses adapt to nullify the effectiveness of the anti-viral drug symmetrel (generic name).
The revelation can have significant consequences in leading drug researchers to develop new and more effective means to block influenza and other viruses in the future.
Influenza, Prof. Arkin emphasizes, is a major killer, even though many people tend to shrug it off as an unpleasant seasonal nuisance. In the U.S. it is the leading cause of death from infectious diseases, claiming about 40,000 lives annually, mostly among the elderly.
In his research, Arkin, of the Department of Biological Chemistry at the Hebrew University’s Silberman Institute of Life Sciences, has demonstrated how flu viruses counteract the symmetrel drug. Assisting him in his work were graduate students Peleg Astrahan and Itamar Kass, as well as Dr. Matt Cooper from Cambridge University in Britain.
Administered at an early stage at the onset of flu symptoms, symmetrel is intended to destroy the virus by binding to and blocking a proton-conducting channel which the virus needs in order to continue functioning and multiplying.