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Tumour Necrosis Factor alpha (TNF-alpha) blocking agents cause skin disease

3. April 2005 21:54

Members of the second most important family of drugs used to treat rheumatoid arthritis can cause serious dermatological conditions in a quarter of patients under treatment, reveals a study published today in the journal Arthritis Research and Therapy.

Last year saw the withdrawal of frontline anti-arthritis drug Vioxx, which belongs to the cox-2 inhibitors family, when it was revealed that it poses a significant risk of heart attack and stroke. Similar findings were reported for other cox-2 inhibitors, although they are still on the market. This study shows that another family of anti-arthritis drugs, Tumour Necrosis Factor alpha (TNF-alpha) blocking agents, trigger skin conditions in 25% of patients undergoing treatment. TNF-alpha blocking agents are used to halt the process of joint destruction in patients with severe arthritis conditions.

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