St. John’s Wort, the herbal medicinal long thought to relieve symptoms of depression, provides only minor benefits in patients with the most acute depression and perhaps no benefit for those with chronic depression.
The updated review of 37 trials, involving 4,925 patients, reaffirms earlier findings that St. John’s Wort:
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Reduces symptoms of mild-to-moderate depression among adults in a manner similar to antidepressant drugs;
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Causes fewer side effects than some of the older antidepressants on the market; and
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Causes slightly fewer side effects compared with selective serotonin reuptake inhibitors, or SSRIs, the class of antidepressants most recently developed.
The review was led by Professor Klaus Linde of the Centre for Complementary Medicine Research at Technical University in Munich, Germany. The reviewers caution that “uncontrolled use of [St. John’s Wort] is problematic because serious interactions can occur” with a number of frequently used antidepressants and that physicians should regularly ask their patients about their use of St. John’s Wort.
The National Center for Complementary and Alternative Medicine, part of the National Institutes of Health, holds that St. John’s Wort is not a proven therapy for depression.
The review appears in the most recent issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing medical trials on a topic.
All studies were double-blind, randomized clinical trials involving patients with depressive disorders. All involved comparisons between St. John’s Wort and placebos or synthetic antidepressants given for at least four weeks.
St. John’s Wort is available over the counter in the United States, where lifetime depression has an estimated prevalence of 16 percent.
In Europe, St. John’s Wort generally can be obtained only by prescription and is used to treat anxiety and sleep disorders as well as depression. St. John’s Wort has been subject to more trials in Europe, especially in German-speaking countries, than in the United States. However, because it is prescribed for a number of disorders other than depression, Linde and colleagues included in their review only those trials from German-speaking countries that were restricted to patients with a diagnosis of major depression.
St. John’s Wort, scientifically referred to as hypericum extracts, derives its name from the patron saint of nurses and Old English word for “plant.” The mechanism by which it acts is unclear, but St. John’s Wort is known to contain at least seven groups of components that may contribute to its pharmacological effects. While some of the components individually have been shown to have a positive effect on some forms of depression, the total extract seems more clearly beneficial.