A collaboration between scientists at UCLA, Caltech, Stanford, Siemens and Fluidigm have developed a new technology using integrated microfluidics chips for simplifying, lowering the cost and diversifying the types of molecules used to image the biology of disease with the medical imaging technology, Positron Emission Tomography (PET).
These molecules are used with PET to diagnostically search throughout the body to look for (image) the molecular errors of disease and to guide the development of new molecular therapeutics.
PET is a new generation of medical imaging for examining the biology of disease that has been shown to dramatically improve the detection of cancer, stage the extent of cancer throughout the body, detect recurrence of cancer and to help select the right therapy for individual patients.
In Alzheimer's disease, PET has been shown to have a 93% accuracy in detecting Alzheimer's about three years before the conventional diagnosis of "Probable Alzheimer's", when integrated into the clinical workup of patients. In addition, PET has been shown to detect Alzheimer's and other neurological disease years before even symptoms are expressed. PET is also employed to determine which patients with cardiovascular disease will benefit from bypass surgery and angioplasty.
These and other clinical uses of PET employ a labeled version of the sugar glucose, called Fluorodeoxyglucose (FDG). Glucose is a critical fuel for cells throughout the body to perform their normal functions. For example, 95% of the energy for the brain to function comes from glucose. In addition, cancer cells increase their metabolism of glucose about 25 fold. There were about three million clinical PET studies performed in clinical services throughout the world in 2005.
Published this week in the journal Science, scientists demonstrated a new technology of a programmable chip that can dramatically accelerate the development of many new molecular imaging molecules for PET. As a proof of principle, this group of academic and commercial scientists demonstrated that FDG could be synthesized on a "stamp-size" chip. These chips have a design similar to integrated electronic circuits, except they are made up of fluid channels, chambers and values (switches) that can carry out many chemical operations to synthesize and label molecules for PET imaging. All the operations of the chip are controlled and executed by a PC.