People with diabetes who keep their blood sugar in check today will probably have a far lower chance of developing foot pain or other nerve damage tomorrow, according to new research results from a national study.
In fact, the study shows that the positive effects of tight blood glucose control can be seen more than a decade later. At the end of the study period, patients who had controlled their blood sugar tightly ever since the start of the study were 51 percent less likely to have nerve problems than patients who started the study at the same time but did not have the initial 5 year period of intensive blood sugar control.
The study, published in the February issue of the journal Diabetes Care, involved 1,441 people with Type 1 diabetes, also known as juvenile diabetes. Although patients with the more common Type 2 form of diabetes were not involved, the results may have implications for the 18 million Americans with Type 2 diabetes.
Two-thirds of all people with diabetes have some degree of nerve problems, or neuropathy, related to their diabetes. The most common sign is numbness or pain in the feet and legs, which can progress over time to cause disability. Neuropathy plays a major role in 80,000 foot and leg amputations in American diabetics each year.
"This is an exciting finding that adds credence to the idea of metabolic memory, or the concept that there can be a durable effect from early and sustained efforts to keep blood sugar low," says senior author Eva Feldman, M.D., Ph.D., the DeJong Professor of Neurology at the University of Michigan Medical School and director of the U-M Neuropathy Center. "It suggests that good glucose control clearly protects patients over the long term."
The new study marks the first time that tight blood sugar control has been shown to have a long-term effect on the chance that a person with diabetes will develop neuropathy. Similar findings have been made for two other frequent complications of diabetes, retinopathy (eye disease) and nephropathy (kidney disease).
The new findings come from the Epidemiology of Diabetes Intervention and Complications (EDIC) study that grew out of the national Diabetes Control and Complications Trial (DCCT). Funded by the National Institute of Diabetes and Digestive & Kidney Diseases, the DCCT began in the 1980s by randomly assigning people with Type 1 diabetes to either tight blood-sugar control using three insulin injections per day or an insulin pump, or to more typical blood sugar control for the time, using one to two insulin injections a day. The latter group was later encouraged to adopt tight blood sugar control, and the EDIC study tracked all patients' health.
The new paper reports results from eight years of neuropathy assessments under the EDIC study, among 1,441 DCCT participants who had no symptoms or signs of neuropathy at the end of the DCCT.
The symptoms and signs were assessed using a standardized questionnaire developed and validated by U-M researchers from the Michigan Diabetes Research and Training Center. Called the Michigan Neuropathy Screening Instrument, the questionnaire is completed by both patients -- who report symptoms such as tingling, pain, numbness, and sensitivity -- and by physicians, who complete a physical examination of the patients' feet, including sensitivity to touch and vibration, and the presence of calluses and sores that the patients might not be able to feel because of nerve damage.
Such foot problems can become infected and lead to open wounds that can be hard to heal because of other aspects of diabetes. Unhealed infections, if bad enough, can lead to decisions to amputate toes, feet and legs. This "domino effect" starting with neuropathy and leading to infection and amputation is the reason that current guidelines call for people with diabetes to have annual foot exams.
Feldman, who led the analysis along with research nurse Catherine Martin, M.S., notes that the study looked at the percentage of participants who had any positive sign of neuropathy on their questionnaire or their foot examination each year of the EDIC study, and then separated them according to which DCCT group (tight glucose control or regular control) they had been in.