Some women with menstrual cycle disorders like asthma and migraine headaches may be experiencing allergies to their own estrogen and progesterone hormones, Texas researchers have discovered.
Russell Roby, M.D., director of the Roby Institute, Dr. Dick Richardson, professor at The University of Texas at Austin, and Dr. Aristo Vojdani, of Immunosciences Lab, Inc. in California, found that female patients who experienced health changes during their menstrual cycle had higher levels of IgE antibodies against progesterone and estrogen than control subjects. An increase in IgE antibodies is typically associated with allergic response.
The researchers published their findings in the March 27 issue of the American Journal of Reproductive Immunology.
"This is going to explain a lot of unexplained illnesses," says Roby, alumnus of The University of Texas at Austin. "The primary disorders are premenstrual asthma, menstrual migraines, interstitial cystitis and fibromyalgia. We have no idea what causes these things, but they are definitely linked to hormonal cycles."
The researchers studied blood samples from healthy women and women who experienced symptoms associated with their menstrual cycles, like asthma, migraines and joint pain. A significant number of patients in the latter group showed high levels of IgG, IgM and IgE antibodies against estrogen and progesterone.