A protein called calpain can be the key either preventing or promoting the cell death, a Queen's University study has found.
"This work provides proof in principle that pharmacological inhibition of calpain may be used to block cell death in situations where this is not desirable, such as in neuronal cells of Alzheimer's or Parkinson's patients, but to promote cell death in cancer cells where this is clearly a very desirable outcome," says lead researcher Peter Greer of two studies appearing in the Journal of Biological Chemistry (JBC).
Dr. Greer is a Professor of Pathology and Molecular Medicine with the Cancer Biology and Genetics division of Queen's University's Cancer Research Institute.
"All cells in our body have the ability to trigger an intrinsic programmed cell death response. In the case of nerve cells that have been temporarily cut off from their oxygen supply because of a stroke, or damaged by amyloid deposits, this might seem like a bad thing that could contribute to neurodegenerative disease," says Dr. Greer who produced the study with Yinfei Tan, Nathalie Dourdin, Chao Wu, Teresa De Veyra, and John S. Elce.
"On the other hand, when a cell's chromosomes are damaged by carcinogens or ultraviolet light in a way that could initiate cancer, this same programmed cell death response could save your life."