Pancreatic cancer patients face the worst survival rates compared to all other forms of human cancer as the disease is nearly impossible to diagnose at an early stage when successful treatments might be possible.
Owing to late stage diagnosis, the remaining clinical options are limited to chemotherapeutic approaches involving the use of such drugs as gemcitabine and 5-fluorouracil (5-FU). The popular chemotherapeutic agents have produced limited clinical success and Northeastern University professor Robert B. Campbell wanted to know why.
Campbell and his graduate student investigated whether or not mucin overexpressed on the surface of human pancreatic tumor cells might act as a physical barrier, limiting the drug's effectiveness.
The article discussing the experiment, titled “Mucin Impedes Cytotoxic Effect of 5-FU against Growth of Human Pancreatic Cancer Cells; Overcoming Cellular Barriers for Therapeutic Gain” is published in this month's issue of The British Journal of Cancer.
“In order to improve treatment approaches, we must consider the biology of pancreatic tumors at the molecular, cellular and physiological levels,” said Dr. Campbell, Assistant Professor of Pharmaceutical Sciences at the Northeastern's Bouvé College of Health Sciences. “Our experimental findings in this study suggest that mucin is in fact a cellular barrier limiting chemotherapeutic action of 5-FU against human pancreatic cancer cells, making 5-FU less effective.”