Cancer Research UK scientists have identified a long sought after enzyme that plays a critical role in a DNA repair pathway linked with inheritable breast and ovarian cancer, reveals research published in Nature.
Familial breast cancers, such as those caused by mutation of the BRCA2 tumour suppressor, are caused by defects in a pathway that rejoins breaks in the DNA.
After an 18-year search, scientists have found a new factor - known as GEN1 - that plays a crucial role in this pathway, and it is likely that this factor may be important for preventing cancer.
This finding expands our understanding of how inheritable breast cancers develop and it is possible that mutations in GEN1 may also be linked with other types of cancer.
Professor Stephen West, based at Cancer Research UK's Clare Hall laboratories, part of the London Research Institute, said: "This is an important enzyme that plays a key role in cellular reactions that repair damaged DNA. Our finding that this enzyme acts in the same pathway as BRCA2 suggests that it is going to be important for cancer prevention."
Breaks in DNA are repaired by a process known as recombinational repair, which is regulated by BRCA2. During this process, the broken DNA joins with a DNA template to form a four-way DNA junction.
The GEN1 enzyme found in this study acts as a pair of 'scissors' that cuts the four-way junction - a reaction that is essential for forming normal DNA. Loss of this enzyme is thought to lead to genetic damage that can result in cancerous tumours forming.