Distrust of medical research appears more common among African American parents than white parents and may present a barrier to enrollment of minority children in research studies, according to a report in the February issue of Archives of Pediatrics & Adolescent Medicine.
The inclusion of ethnic minorities and children in research helps ensure that results can be applied to the general population, according to background information in the article. The National Institutes of Health have mandated that researchers include representatives of these groups. However, African Americans frequently remain underrepresented. "African Americans' distrust of medical research has been suggested to be an important reason for their lack of participation," the authors write. "This distrust may be attributed both to a cultural memory of victimization and exploitation during clinical experiments, such as in the Tuskegee Syphilis Study, and to personal experiences with discrimination."
Kumaravel Rajakumar, M.D., of the University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, and colleagues surveyed 190 parents (140 African American and 50 white) who accompanied their children to a primary care clinic between August 2004 and April 2005. In addition to demographic characteristics, participants were asked about their attitudes toward their child's medical care, beliefs about medical research and whether incentives (such as money or free medical care) would affect their decision about allowing their child to participate in research.
As compared with white parents, African American parents:
- More often reported distrust of medical research, when questions assessing trust were combined and analyzed (67 percent vs. 50 percent)
- More often believed that physicians prescribe medications as a way of experimenting on unknowing patients (40 percent vs. 28 percent)
- Were more likely to believe that medical research involves too much risk to the participant (46.8 percent vs. 26 percent), that physicians will not make full disclosures regarding their child's participation (24.6 percent vs. 10 percent) and that research participants would be favored and receive better medical care (48.6 percent vs. 28 percent)
Education level was also associated with distrust, with high distrust scores among 74 percent of those with less than a high school education vs. 44 percent of college graduates. However, race remained associated with higher levels of distrust even after the researchers controlled for education, with African American parents having two times the odds of being distrusting compared with white parents.
"Although the overall attitude toward medicine and research was positive in both African American and white parents, the degree of distrust was significantly greater among African American parents," the authors write. "Our data suggest that African American parents with higher levels of distrust are less likely to enroll their children in clinical research. Additionally, traditional incentives (financial compensation and free medicine, transportation and medical care) did not overcome the barrier of high distrust."