Chronic exposure to tobacco smoke in childhood may contribute to early emphysema later in life, according to new research.
Environmental tobacco smoke (ETS) is known to be associated with a variety of serious health problems, but it had not previously been associated with the development of emphysema over the life course. The data will be presented on Tuesday, May 19, at the 105th International Conference of the American Thoracic Society in San Diego.
"Emphysematous 'holes' in the lung that begin as small areas of damage or impaired development may expand according to a fractal trajectory after an earlier insult," said Gina Lovasi, M.P.H., Ph.D., of Columbia University. "We hypothesized that environmental tobacco smoke in childhood may be one such early insult, associated with signs of early emphysema detectable on computed tomography (CT) scan in adulthood and perhaps lower lung function detectable by spirometry."
Emphysema is an anatomically defined condition that overlaps substantially with chronic obstructive pulmonary disease, the fourth leading cause of death worldwide. Although smoking leads to emphysema in the upper lobes of the lungs, people who have never smoked may also have tissue destruction patterns that indicate emphysema. However, emphysema in people who have never smoked is more likely to appear as diffuse damage throughout the lungs.
To determine whether chronic exposure to ETS in childhood could lead to the development of early emphysema later in life, Dr. Lovasi and colleagues analyzed data from a diverse sample of 3,964 relatively healthy adults recruited as part of the Multi-Ethnic Study of Atherosclerosis (MESA) study, focusing on 1,781 adults who had never smoked. The MESA-lung study assessed childhood exposure to ETS by asking each participant "In your childhood, did you live with a regular cigarette smoker who smoked in your home?"
The MESA-lung study was also the first large study of healthy adults to collect CT images that show most of the lungs, allowing for the classification of some areas of the lungs as having indications of early emphysema: large contiguous areas of air-like density ("holes", in contrast to lung tissue, which is more dense than air) or the total percentage of lung volume with air-like density.