UCD Conway researchers have characterised epigenetic signature changes in prostate cells under conditions of low oxygen levels that may lead to tumour development.
The results of the study published this month in the scientific journal, Human Molecular Genetics may provide important targets for the early detection and manipulation of prostate cancer.
Chronic hypoxia, or low tissue oxygen levels, is a natural feature of the aging prostate either due to declining blood flow to the area or local consumption of oxygen during re-modelling of the organ. It may also be a risk factor in the development of prostate cancer but, to date, the processes involved are not defined.
This study led by Conway Fellow, Dr Amanda McCann, and involving collaborators in UCD Conway Institute as well as teams in St Vincent’s University Hospital, the National Centre for Medical Genetics Crumlin and Cancer Research UK Cambridge Research Institute, examined the consequences of chronic hypoxia in prostate cells.
The group found significant epigenetic and cellular alterations in prostate cells as a result of hypoxia. Epigenetic changes alter the appearance or expression of genes but not their underlying DNA structure. Cells became more resistant to the natural process of cell death, increasingly able to migrate or invade and also caused the secretion of chemical messengers that are believed to be involved in the growth and survival of prostate tumour cells.