The development of new antiviral drugs has had a tremendous impact on the quality of life and life expectancy of HIV-positive and AIDS patients, as the drugs effectively disrupt the replication cycle of the HIV virus. Yet the regular use of those drugs - such as zidovudine (also known as azidothymidine or AZT), protease inhibitors, and highly active antiretroviral therapy (HAART) involving multidrug therapies - has led to resistant HIV strains. Recognizing the need for different therapies that target different steps in the infection process, scientists with HerbalScience have identified for the first time key chemical components in elderberry, cinnamon, and green tea extracts that bind to the HIV viruses and block them from infecting target cells in the laboratory.
An article detailing the research, titled "HIV type-1 entry inhibitors with a new mode of action," appears in the current issue of Antiviral Chemistry & Chemotherapy, a peer-reviewed scientific journal. The authors are affiliated with the University of Miami Leonard Miller School of Medicine, Miami, Florida, and HerbalScience Group LLC, a Naples, Florida, and Singapore-based company dedicated to applying advanced science and technology to the production of botanical drugs and nutraceuticals.
"HIV/AIDS is a global public health crisis, so these research results are promising for several reasons," said Randall S. Alberte, Ph.D., Chief Scientific Officer of HerbalScience and one of the authors of the published study. "First, they open the door to the possibility of developing alternative means to reduce viral loads in HIV infected individuals, as well as a less expensive means to provide alternative treatments to those who are unable or cannot afford to receive traditional drug therapies. In addition, such botanical materials may offer new sources of anti-HIV drugs that can address resistance generation and be complementary to current treatments."
Previous research by HerbalScience had demonstrated the ability of its proprietary elderberry extract to inhibit entry of the H1N1 influenza virus into target cells. For the HIV study, researchers used the same elderberry extract, and compared the antiviral activities to those of extracts obtained from green tea and cinnamon, two botanicals that are also known to be rich in flavonoids, plant nutrients that are beneficial to health. All the extracts were prepared using the company's patented extraction technologies, which standardize the chemical profile of any selected botanical in order to deliver a compositionally and functionally consistent product, batch to batch.