Shire plc (LSE:
SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company,
announces that the United States District Court for the District of Columbia
("Court"), following extensive briefing by the parties and an oral hearing,
has upheld the decision of the U.S. Food and Drug Administration ("FDA") to
grant 5-year New Chemical Entity ("NCE") exclusivity to lisdexamfetamine
dimesylate-currently marketed by Shire U.S. Inc. for the treatment of
attention-deficit hyperactivity disorder under the name VYVANSE(R).