At ASMS 2012, Bruker announces the launch of the new ultrafleXtreme™
MALDI TOF/TOF system. Bruker's market leading, top of the range product
has been significantly enhanced to offer both increased analytical power
and entirely new functionality, extending the applications envelope of
MALDI TOF/TOF far beyond the conventional concepts of what's possible in
molecular histology, glycoprotein and biopharmaceuticals analysis.
Already the acknowledged leader in Mass Spectrometry Imaging (MSI), the
next-generation ultrafleXtreme system incorporates the
Bruker patented smartbeam™ laser, now with up to 2 kHz
repetition rate with true-pixel image resolution at 20µm for proteins.
This development marks a new milestone in the pioneering smartbeam
laser technology, designed and manufactured exclusively by Bruker for
unmatched performance in MALDI mass spectrometry.
While biomarker discovery in large tissue-sample cohorts can now be
achieved at record high speed, Bruker has also significantly extended
the discovery potential of Molecular Histology with the new ImageID™
workflow. The proprietary ImageID workflow is a
fully-integrated process to provide scientists with integrated tissue
maps for both protein distribution and identification. More than 100
proteins are typically characterized by the ImageID
workflow, where consecutive histological sections are processed in
parallel to generate complementary datasets in a single software
environment for comprehensive analysis. ImageID yields
identifications of approximately 80% of all peptides observed in imaging
measurements, also those derived from high molecular weight proteins.
For the first time, the method can access fixed (FFPE) tissue, allowing
molecular histology to be applied to vast collections of archived
clinical samples to unlock a potential treasure chest of biomarker data
in cancer studies.