Published on July 10, 2012 at 12:30 AM
In order to determine the relationship between EGF and tumor
development, the investigators blocked EGF and expected to also block
colon tumor development. Surprisingly, they discovered that inactivating
EGF resulted in increasingly severe colitis and dramatically increased
colon tumor growth.
In a paper published online in the Journal of Clinical Investigation
(July 9, 2012) they reported that EGF encourages healing and provides
powerful anti-inflammatory properties; together, these functions
actually prevent inflammation-induced cancer, superseding any potential
"There is a great need for these new therapies, as current medicines and
surgical options for IBD patients cause many debilitating side effects,"
said Dubé, who is first author on the paper. "By building on the body's
natural healing system, we believe that we can develop therapies for IBD
that are not only highly effective but, most importantly, safe."
Source: Children's Hospital Los Angeles