Cannabis Science (CBIS), a pioneering U.S. Biotech Company developing pharmaceutical to meet global public health challenges is pleased to announce the initiation of GMP development plan for CS-TATI-1 with the initial production of CS-TATI-1 to be performed in Colorado under C-GMP conditions evaluated by the FDA for initial human studies to treat HIV associated Kaposi Sarcoma.
“Our analysis of utilizing an endosome based transdermal delivery of CS-TATI-1 in our initial studies will be optimal for addressing regulatory compliance concerns and meet the need of patients who are in need of effective localized delivery of the clinical activity of Cannabis Science's flagship therapeutic agent”
CBIS CS-TATI-1 is a preclinical development program intended to address the presentation of KSHV transactivation by HIV TAT. The codependent relation of the TAT's expression at the HIV LTR and the upregulation of Nf-KB dependent expression of Kaposi Sarcoma is well defined in peer reviewed publications.