Alere Triage PLGF test can help quantify delivery risk in women with suspected pre-eclampsia

Published on October 8, 2012 at 3:39 AM · No Comments

Alere Inc. (NYSE: ALR) is pleased to announce the results of a study, presented today at the 20th FIGO World Congress of Obstetrics and Gynecology, which demonstrate that a simple blood test measuring placental growth factor (PlGF) can help to quantify risk in women when pre-eclampsia is first suspected. The level of PlGF in blood is already known to be an important marker for placental and foetal wellbeing as well as the placenta's ability to sustain the pregnancy.

This UK-based, multi-centre study known as PELICAN used the Alere Triage® PLGF test to measure PlGF levels in 625 women with suspected pre-eclampsia in their first clinic visit. In women presenting before 35 weeks gestation who were managed in accordance with standard clinical protocols, a high PlGF level was strongly correlated with low risk for required delivery in the next 14 days.  In fact, 96% of women with a normal test result were correctly diagnosed as not at risk. Conversely, a low PlGF level accurately identified women at high risk for preterm delivery, and 94% of women with an abnormal test result went on to require early delivery.

Professor of Obstetric Medicine at the University of Oxford and PELICAN investigator, Christopher Redman commented, "Pre-eclampsia is notoriously unpredictable. Reliable tests that can be used in the clinical setting, when pre-eclampsia is first suspected, would be a notable breakthrough in the management of this life-threatening condition. The PELICAN data have demonstrated that PlGF testing before 35 weeks enables physicians to categorise women into low and high risk for disease progression and to adjust clinical management appropriately."

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