Researchers from the University of Bonn treated mice with Viagra and made an amazing discovery: The drug converts undesirable white fat cells and could thus potentially melt the unwelcome "spare tire" around the midriff. In addition, the substance also decreases the risk of other complications caused by obesity. The results are now published in "The Journal of the Federation of American Societies for Experimental Biology" (FASEB).
Sildenafil - better known as Viagra - is used to treat erectile dysfunction. This substance prevents degradation of cyclic guanosine mono-phosphate (cGMP), which then ensures blood supply for an erection. However, another effect of Viagra has been noticed quite some time ago - mice given sildenafil over longer periods of time were resistant to obesity when fed with high-fat diet. However, the cause for this reduced weight gain had been unclear. Researchers from the University of Bonn have been able to shed some light on this sildenafil effect. "We have been researching the effect of cGMP on fat cells for quite some time now," reports Prof. Dr. Alexander Pfeifer, Director of the Institute for Pharmacology and Toxicology at the University of Bonn. "This is why sildenafil was a potentially interesting candidate for us."
Viagra converts undesirable white fat cells into beige ones
Together with the PharmaCenter of the University of Bonn, the German Federal Institute for Drugs and Medical Devices (BfArM), and the Max Planck Institute for Heart and Lung Research, the team around Prof. Pfeifer studied the effect of sildenafil on fat cells in mice. The researchers administered the potency drug to the rodents for seven days. "The effects were quite amazing," says Dr. Ana Kilic, one of Prof. Pfeifer's colleagues. Sildenafil increased the conversion of white fat cells, which are found in human 'problem areas', into beige ones in the animals. "Beige fat cells burn the energy from ingested food and convert it to heat, says Prof. Pfeifer. Because the beige fat cells can "melt the fat" and thus fight obesity, researchers are very hopeful for their potential.
Positive effect on inflammation responses