Harvard's Wyss Institute completes first clinical study of new rapid neuroassessment device

Published on February 10, 2013 at 9:09 PM · No Comments

Doctors routinely track their patients' hand-eye coordination to monitor any neuromuscular deficits, particularly as patients age or when they are injured -- but the tests they have been using to track this kind of information may be subjective and qualitative.

Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University, the Beth Israel Deaconess Medical Center, and Hebrew SeniorLife, Boston (BIDMC), recently completed the first clinical study of a new rapid neuroassessment device they developed to quantitatively measure neuromuscular performance, as reported online in yesterday's Journal of Gerontology: Series A: Biological Sciences and Medical Sciences.

In the study, 150 healthy people from the Boston area aged 21 to 95 used a stylus to follow a moving target around a circle on a computer tablet. As every person performed this tracing task, proprietary computer methods developed at the Wyss Institute measured people's deviations from the circular path, which the researchers then analyzed as a function of age, sex, and handedness. Using this approach, a number can be obtained that can show differences in performance between various individuals or conditions. An older person performs quite differently on the tracing exercise, for example.

"This new tool may hold great potential to augment existing protocols in a doctor's neuromotor assessment toolbox," said Wyss Senior Staff Engineer Leia Stirling, Ph.D., who led the study. "It is portable, repeatable, quick to administer, and easy to perform."

Whereas current methods to assess a patient's neuromuscular function include subjective descriptions of a patient's reflexes and cognitive status, the tracing tool could add a slew of new information displayed as a "score". For example, doctors can record a "score" for "complexity," which relates to how well a person can adapt to changes, and "motion fluidity," which relates to how long the patient pauses during the task. Older subjects involved in the study had lower complexity and motion fluidity scores.

Wyss Core Faculty member Ary L. Goldberger, M.D., who is also the Director of the Margret & H. A. Rey Institute for Nonlinear Dynamics in Medicine at BIDMC, introduced the idea of studying complexity in the human body. "We have demonstrated in earlier studies that a loss of complexity is potentially associated with a range of human health issues from congestive heart failure and sleep apnea to aging," he said.

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