Researcher to study ADAM12 gene in breast tumor initiating cells

Published on February 14, 2013 at 7:16 AM · No Comments

A Kansas State University professor's research on breast cancer stem cells may help improve survival rates by preventing cancer recurrence and metastasis -- the major causes of death among breast cancer patients.

Anna Zolkiewska, associate professor of biochemistry and molecular biophysics, has received a four-year $1.245 million grant from the National Cancer Institute -- at the National Institutes of Health -- to study a promising breast cancer marker called ADAM12. The grant is titled "ADAM12 in breast tumor initiating cells."

The grant currently is the biggest National Cancer Institute commitment to fund a single investigator at Kansas State University. Zolkiewska also is completing a three-year $444,000 grant from the National Institutes of Health for research on mutations in the ADAM12 gene.

Zolkiewska's research focuses on breast tumor initiating cells, called BTICs, which also are known as cancer stem cells. These cells drive breast tumor progression and tumor recurrence or metastasis.

"Our studies strive to produce new research and diagnostic tools for detection of breast tumor initiating cells and to develop new therapies to target these cells," Zolkiewska said.

While current treatments for breast cancer -- such as surgery, chemotherapy and radiation therapy -- can destroy the majority of tumor cells, these treatments cannot eradicate cancer stem cells. Current treatments also have many negative side effects.

"The problem is that cancer stem cells are present in very low amounts," Zolkiewska said. "They are difficult to detect. But we know that they exist and they are practically resistant to chemotherapy and radiation therapy."

Even when chemotherapy appears to work, breast tumor initiating cells can cause tumors to re-emerge or metastasize to bones, lungs or the brain.

"Once metastasis occurs, the chances to cure the patient decrease dramatically," Zolkiewska said. "It is absolutely critical to be able to identify cancer stem cells and to find more effective treatments against them."

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