Autism, ADHD, bipolar disorder, major depressive disorder and schizophrenia share common genetic risk factors

According to Smoller, “Significant progress has been made in understanding the genetic risk factors underlying psychiatric disorders. Our results provide new evidence that may inform a move beyond descriptive syndromes in psychiatry and towards classification based on underlying causes. These findings are particularly relevant in view of the imminent revision of classifications in the Diagnostic and Statistical Manual of Mental Disorders (DSM) and the International Classification of Diseases (ICD).”

Writing in a linked Comment, Alessandro Serretti and Chiara Fabbri from the University of Bologna in Italy say, “the present study might contribute to future nosographic [classification] systems, which could be based not only on statistically determined clinical categories, but also on biological pathogenic factors that are pivotal to the identification of suitable treatments.”

They add, “genetics…can contribute to prediction and prevention of psychiatric diseases, along with the identification of molecular targets for new generations of psychotropic drugs.”

Source: The Lancet