Published on October 25, 2013 at 9:25 AM
Additionally, in patients with asthma and COPD, there was rapid bronchodilation with peak effects similar to those produced with inhaled ß2 agonists. Repeat dosing in asthmatics for 6 days showed that the bronchodilator effects were maintained.
Findings also showed that RPL554 can inhibit the bacterial component lipopolysaccharide (LPS) in healthy subjects suggesting that RPL554 also possesses significant anti-inflammatory activity.
Overall, RPL554 was well tolerated and patients in the treatment and placebo groups experienced similar rates of adverse events, which were generally mild. “Although other PDE4 inhibitors can cause gastrointestinal side effects when given orally, none were reported at any dose of RPL554 tested in these trials”, explains study leader Professor Clive Page from King’s College London, UK.
According to Professor Page, “These studies give us a glimpse into the potential bronchodilator, bronchoprotective, and anti-inflammatory effects of this drug. So far trials have run for 7 days or less and there is a need to look at longer-lasting effects. Further studies are needed to better understand the full potential of this new therapy for COPD and asthma.”