New spherical nucleic acid drug crosses blood-brain barrier to target brain tumors in animals
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  May 21, 2017  
  Huntington's Disease  
  The latest huntington's disease news from News Medical  
 New spherical nucleic acid drug crosses blood-brain barrier to target brain tumors in animalsNew spherical nucleic acid drug crosses blood-brain barrier to target brain tumors in animals
 
The first drug using spherical nucleic acids to be systemically given to humans has been developed by Northwestern University scientists and approved by the Food and Drug Administration as an investigational new drug for an early-stage clinical trial in the deadly brain cancer glioblastoma multiforme.
 
 
 Scientists use AHDS patients’ cells to recreate disease and mimic blood-brain barrierScientists use AHDS patients’ cells to recreate disease and mimic blood-brain barrier
 
The blood-brain barrier is biology's proverbial double-edged sword. An impermeable shield of endothelial cells that protects our brains from toxins and other threats that may lurk in circulating blood, the barrier can also exclude therapeutic drugs and, at times, essential biomolecules required for healthy brain development.
 
   Neurobiologists uncover reason for defects in the blood-brain barrier of Huntington's disease patientsNeurobiologists uncover reason for defects in the blood-brain barrier of Huntington's disease patients
 
By using induced pluripotent stem cells to create endothelial cells that line blood vessels in the brain for the first time for a neurodegenerative disease, University of California, Irvine neurobiologists and colleagues have learned why Huntington's disease patients have defects in the blood-brain barrier that contribute to the symptoms of this fatal disorder.
 
   ‘Disease in a dish’ model pinpoints how defects in blood-brain barrier can cause psychomotor disorder‘Disease in a dish’ model pinpoints how defects in blood-brain barrier can cause psychomotor disorder
 
Scientists for the first time have assembled a "disease in a dish" model that pinpoints how a defect in the blood-brain barrier can produce an incurable psychomotor disorder, Allan-Herndon-Dudley syndrome.
 
 Researchers discover how tau disrupts functioning of nerve cells even before forming tangles
 
Researchers discover how tau disrupts functioning of nerve cells even before forming tanglesTau proteins are involved in more than twenty neurodegenerative diseases, including various forms of dementia.
 
 
 Scientists to develop drugs for treating cognitive deficits in Huntington's disease sufferers
 
Scientists to develop drugs for treating cognitive deficits in Huntington's disease sufferersScientists at the University of Sussex have started work on a multi-million pound project to develop drugs to treat the debilitating loss of cognitive function associated with Huntington's disease.