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Antidepressant amitriptyline works just as well as placebo for children with gastrointestinal disorders When used "off-label," the antidepressant amitriptyline works just as well as placebo in treating pain-predominant gastrointestinal disorders in children, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. To view this article's video abstract, go to the AGA's YouTube Channel at www.youtube.com/AmerGastroAssn. http://www.news-medical.net/news/20091001/Antidepressant-amitriptyline-works-just-as-well-as-placebo-for-children-with-gastrointestinal-disorders.aspx
Mayo Clinic scientists conduct clinical study on functional dyspesia patients "Nerve cells are found throughout the body, and just as their dysfunction in the brain can cause depression, we suspect overly sensitive nerves in the gut can produce this very uncomfortable indigestion," says Nicholas Talley, M.D., Ph.D., chair of the trial and chair of the Department of Internal Medicine at the Mayo Clinic campus in Florida. http://www.news-medical.net/news/20090918/Mayo-Clinic-scientists-conduct-clinical-study-on-functional-dyspesia-patients.aspx
Compound from coral offers hope fpr neuropathic pain A compound initially isolated from a soft coral (Capnella imbricata) collected at Green Island off Taiwan, could lead scientists to develop a new set of treatments for neuropathic pain - chronic pain that sometimes follows damage to the nervous system. http://www.news-medical.net/news/20090804/Compound-from-coral-offers-hope-fpr-neuropathic-pain.aspx
New antidepressants might be no more effective than the best existing drugs The reviews suggest that sertraline - sold under the brand name Zoloft since 1991- could be the best initial choice of antidepressant in people with acute major depression. The generic formulation produced the best balance of effectiveness, tolerability and purchase price, the authors say. http://www.news-medical.net/news/2009/05/05/49202.aspx
Antidepressant amitriptyline shown to alleviate symptoms of irritable bowel syndrome Researchers at Mattel Children's Hospital UCLA have found that low-dose antidepressant therapy can significantly improve the overall quality of life for adolescents suffering from irritable bowel syndrome (IBS). http://www.news-medical.net/news/2008/05/01/37991.aspx
Antidepressants might be worthless for treating low back pain The review appears in the latest issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing medical trials on a topic. http://www.news-medical.net/news/2008/01/30/34766.aspx
EpiCept to conduct Phase III study of EpiCept NP-1 for treatment of chemotherapy induced peripheral neuropathy EpiCept Corporation has announced that it will study EpiCept NP-1, its patented topical cream formulation of two FDA-approved drugs, 4% amitriptyline and 2% ketamine, for the treatment of chemotherapy induced peripheral neuropathy (CPN) in the ATTRACT-CPN Phase III Study (Assessment of Topical Treatment Response with Amitriptyline and Ketamine: Combination Trial in Chemotherapy Peripheral Neuropathy). http://www.news-medical.net/news/2007/07/23/27914.aspx
An outsider's view of chronic fatigue syndrome may provide clues to how we perceive Clinical methodology and its implications for the study of therapeutic interventions for chronic fatigue syndrome (CFS). http://www.news-medical.net/news/2006/06/28/18623.aspx
Older-style antidepressants, as well as anticonvulsant drugs, can help ease the disabling pain caused by nerve tissue damage For many years antidepressants, which are believed to work by dampening pain signals, have been the first-line drugs for neuropathic pain. "It is usual to start with an antidepressant like amitriptyline, and if this fails then try an anticonvulsant," says Phil Wiffen, a researcher at Churchill Hospital in Oxford, England. "The results of these meta-analyses suggest this is probably still the best approach to take." http://www.news-medical.net/news/2005/07/19/11847.aspx
Elderly people in the U.S. are being inappropriately prescribed medications In the U.S. only 15 percent of the population is aged 65 years or older, but this group account for 33 percent of prescription drug users. Elderly persons are also more likely to take several drugs concurrently, the article states. http://www.news-medical.net/news/2004/08/10/3955.aspx
Suicidal behavior is higher in the first month after starting antidepressants A new study in the current issue of The Journal of the American Medical Association reports that the risk of suicidal behavior is higher in the first month after starting antidepressants. http://www.news-medical.net/news/2004/07/20/3430.aspx
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