Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Study examines association between neighborhood disadvantage and DNA methylation in brain tissue

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, "The association between neighborhood deprivation and DNA methylation in an autopsy cohort."

9 May 2024

Ensemble deep learning models enhance early diagnosis of Alzheimer's disease using neuroimaging data

The developments in ensemble deep learning (EDL) models used to characterize and estimate AD.

9 May 2024

Superagers' brains resist age-related decline, study finds

Researchers explored brain white matter integrity in superagers, older adults with exceptional cognitive abilities, finding that while overall white matter health showed no significant differences, superagers displayed superior microstructure in frontal regions, potentially explaining their resistance to cognitive decline.

8 May 2024

Youth-onset diabetes linked to higher Alzheimer's risk

Young people with diabetes may have a significantly higher risk of developing Alzheimer's disease later in life, according to a new study by researchers in the Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center at the University of Colorado Anschutz Medical Campus.

8 May 2024

FAU researchers receive grants to tackle Alzheimer's disease

Three Florida Atlantic University researchers at the forefront of Alzheimer's disease (AD) research have each received a $350,000 grant from the Florida Department of Health's "Ed and Ethel Moore Alzheimer's Disease Research Program."

8 May 2024

Mathematical microscope sheds light on efficient memory formation even during sleep

UCLA Health researchers have discovered a mechanism that creates memories while reducing metabolic cost, even during sleep.

8 May 2024

APOE4 gene linked to early onset Alzheimer's, target for therapeutic intervention

A study published in Nature Medicine delineates how APOE4 homozygosity distinctly accelerates Alzheimer's disease pathology and biomarkers from the age of 55, suggesting a unique form of the disease and a potential focus for targeted therapies.

8 May 2024

Study identifies APOE4 homozygotes as high-risk group for Alzheimer's disease

Researchers from the Research Area on Neurological Diseases, Neuroscience, and Mental Health at the Sant Pau Research Institute, led by Dr. Juan Fortea, Director of the Memory Unit of the Neurology Service at the same hospital, have found that over 95% of individuals over 65 years old who have two copies of the APOE4 gene -APOE4 homozygotes- show biological characteristics of Alzheimer's pathology in the brain or biomarkers of this disease in cerebrospinal fluid and PET scans.

6 May 2024

Global research offers insights about health burden disparities between genders

Globally, there are substantial differences between females and males (aged 10 and older) when it comes to health, with limited progress in bridging these health gaps over the past 30 years, according to a new study examining the disparities in the 20 leading causes of disease burden between females and males, across ages and regions, published in The Lancet Public Health journal.

2 May 2024

Rapamycin shows promise in slowing Alzheimer's disease progression linked to seizures

Protein imbalances that increase brain cell excitability may explain why individuals with Alzheimer's disease (AD) who also experience seizures demonstrate more rapid cognitive decline than those who do not experience seizures.

2 May 2024

Genes affecting worm behavior found to be relevant to neurological disease in humans

As an undergraduate student in The University of Texas at Arlington's Honors College, Hannah Selvarathinam knew she wanted to conduct research. Near the end of her first year at UTA, the Keller native reached out to the lab of biology Assistant Professor Piya Ghose.

30 Apr 2024

Generation Z urged to prioritize gum health

As Generation Z embarks on their journey into adulthood, there's one crucial aspect of their health that can sometimes be overlooked: their gums.

30 Apr 2024

Benefits and challenges of integrating nursing home residents into clinical trials

Clinical trials are constantly being designed and study participants enrolled to determine if medical treatments and therapies are safe and effective.

29 Apr 2024

New study reveals potential cellular mechanism behind cognitive decline in Alzheimer's

Researchers have developed a robust method for identifying rare brain neurons that re-enter the cell cycle, offering insights into their role in cognitive disorders such as Alzheimer's disease.

28 Apr 2024

New imaging technique provides a much closer look at fibril assemblies

A new imaging technique developed by engineers at Washington University in St. Louis can give scientists a much closer look at fibril assemblies, stacks of peptides like amyloid beta, most notably associated with Alzheimer's disease.

26 Apr 2024

Researchers uncover mechanism behind mitochondrial dysfunction in Alzheimer's

A team of researchers at Johannes Gutenberg University Mainz (JGU) has identified a mechanism that causes mitochondrial dysfunction in Alzheimer's patients resulting in a reduction of the supply of energy to the brain.

25 Apr 2024

Better cardiovascular health among middle-aged Black women linked to less decline in cognition

Better heart health was linked to less decline in mental processing speed and cognition among middle-aged Black women, although not among middle-aged white women, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

24 Apr 2024

Neurons re-entering cell cycle succumb to senescence in neurodegenerative diseases

Post-mitotic neurons in the brain that re-enter the cell cycle quickly succumb to senescence, and this re-entry is more common in Alzheimer's disease, according to a new study published April 9th in the open-access journal PLOS Biology by Kim Hai-Man Chow and colleagues at the Chinese University of Hong Kong.

23 Apr 2024

$4.8 million grant supports research on TDP-43 misfolding in neurodegenerative diseases

A new $4.8 million grant will support researchers from Indiana University School of Medicine and the Medical Research Council Laboratory of Molecular Biology to study how human neurodegenerative diseases are affected by the misfolding of the protein TDP-43.

23 Apr 2024

Bursts of beta rhythms control cognition in the brain

The brain processes information on many scales. Individual cells electrochemically transmit signals in circuits but at the large scale required to produce cognition, millions of cells act in concert, driven by rhythmic signals at varying frequencies.

23 Apr 2024

Alzheimer's Disease News and Research

Further Reading

Study examines association between neighborhood disadvantage and DNA methylation in brain tissue

Ensemble deep learning models enhance early diagnosis of Alzheimer's disease using neuroimaging data

Superagers' brains resist age-related decline, study finds

Youth-onset diabetes linked to higher Alzheimer's risk

FAU researchers receive grants to tackle Alzheimer's disease

Mathematical microscope sheds light on efficient memory formation even during sleep

APOE4 gene linked to early onset Alzheimer's, target for therapeutic intervention

Study identifies APOE4 homozygotes as high-risk group for Alzheimer's disease

Global research offers insights about health burden disparities between genders

Rapamycin shows promise in slowing Alzheimer's disease progression linked to seizures

Genes affecting worm behavior found to be relevant to neurological disease in humans

Generation Z urged to prioritize gum health

Benefits and challenges of integrating nursing home residents into clinical trials

New study reveals potential cellular mechanism behind cognitive decline in Alzheimer's

New imaging technique provides a much closer look at fibril assemblies

Researchers uncover mechanism behind mitochondrial dysfunction in Alzheimer's

Better cardiovascular health among middle-aged Black women linked to less decline in cognition

Neurons re-entering cell cycle succumb to senescence in neurodegenerative diseases

$4.8 million grant supports research on TDP-43 misfolding in neurodegenerative diseases

Bursts of beta rhythms control cognition in the brain

Aneuro: A Year of Neuroscience in Review eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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