Dopamine News and Research

RSS

Dopamine is a hormone and neurotransmitter occurring in a wide variety of animals, including both vertebrates and invertebrates. In the brain, this phenethylamine functions as a neurotransmitter, activating the five types of dopamine receptors — D1, D2, D3, D4 and D5, and their variants. Dopamine is produced in several areas of the brain, including the substantia nigra and the ventral tegmental area. Dopamine is also a neurohormone released by the hypothalamus. Its main function as a hormone is to inhibit the release of prolactin from the anterior lobe of the pituitary. Dopamine has many functions in the brain, including important roles in behavior and cognition, motor activity, motivation and reward, inhibition of prolactin production (involved in lactation), sleep, mood, attention, and learning. Dopaminergic neurons (i.e., neurons whose primary neurotransmitter is dopamine) are present chiefly in the ventral tegmental area (VTA) of the midbrain, substantia nigra pars compacta, and arcuate nucleus of the hypothalamus.

SSRI antidepressants "hijack" dopamine signaling as well launching serotonin signals

Researchers have discovered that antidepressant drugs such as Prozac not only affect levels of the neurotransmitter serotonin in the brain, but also "hijack" dopamine signaling as well--causing it to launch serotonin signals. Their findings offer new insight into how Prozac and other "selective serotonin uptake inhibitors" (SSRIs) work and how they might cause problems in patients taking them.

6 Apr 2005

Metabolic side effects of antipsychotics are known, but rarely monitored

Psychiatrists are doing a “modest” job of monitoring for weight gain, diabetes and other metabolic problems that may result from use of the newer antipsychotics for schizophrenia, researchers say.

5 Apr 2005

New directions toward the treatment of bipolar disorder

While lithium treatment has proven to be a godsend for many of the two million Americans with bipolar disorder, it is not without its downside. People on the drug may develop hypothyroidism, tremors, cognitive impairment, and excessive thirst and urination and gain weight.

23 Mar 2005

Dopamine sheds new light on drug addiction

A paper published in the current issue of Science has challenged beliefs about the role of dopamine in the brain, which could lead to new treatments for Parkinson’s disease, schizophrenia and drug addiction. The research suggests that dopamine has a far wider, less specialised role than previously hypothesised.

3 Mar 2005

First comprehensive examination of strenuous physical activity and the risk of developing Parkinson's disease

In the first comprehensive examination of strenuous physical activity and the risk of developing Parkinson's disease, researchers from the Harvard School of Public Health (HSPH) have found that men who exercised regularly and vigorously early in their adult life had a lower risk for developing Parkinson's disease compared to men who did not.

22 Feb 2005

How polychlorinated biphenyls open brain cells to Parkinson's assault

University of Rochester scientists investigating the link between PCBs, pesticides and Parkinson's disease demonstrated new and intricate reactions that occur in certain brain cells, making them more vulnerable to injury after exposures.

9 Feb 2005

Inserting corrective genes into the brain to fight Parkinson's disease

An international team of scientists has used gene therapy in two separate studies to renew brain cells and restore normal movements in monkeys and rats with a drug-induced form of Parkinson's disease.

8 Feb 2005

Researchers have identified the cellular receptor for the JC virus

Researchers funded in part by the National Institute of Neurological Disorders and Stroke (NINDS) have identified the cellular receptor for the JC virus, which causes the fatal neurological disease progressive multifocal leukoencephalopathy (PML).

17 Jan 2005

Study identifies potentially valuable applications for new drug Nifrolidine

Along with aiding efforts to study addicted smokers, a new drug that attaches only to areas of the brain that have been implicated in nicotine addiction may help studies of people battling other disorders such as Alzheimer’s disease and schizophrenia.

12 Jan 2005

Restless legs syndrome is underdiagnosed in kids

A new Mayo Clinic study has for the first time established rates of restless legs syndrome in children, finding that almost 6 percent of children seen in Mayo's sleep clinic have the disease.

28 Dec 2004

Significant advance in understanding the human genome

An Oregon Health & Science University-led development of a technique for identifying control elements that drive the expression of genes in brain cells could unleash the disease-fighting potential of the much-hailed human genome.

28 Dec 2004

Botox may be a possible treatment for sufferers of Tourette's syndrome

Researchers at Baylor College of Medicine in Houston are using botulinum toxin type A (Botox) to treat the neurological disorder, which can cause involuntary motor and vocal tics.

21 Dec 2004

Computational model of addiction which can be used to make predictions about human behavior

A University of Minnesota researcher developed a computational model of addiction which can be used to make predictions about human behavior, animal behavior, and neurophysiology.

13 Dec 2004

Rifampicin can prevent the formation of protein fibrils associated with Parkinson's disease

Researchers at the University of California, Santa Cruz, have shown that rifampicin, an antibiotic used to treat leprosy and tuberculosis, can prevent the formation of protein fibrils associated with the death of brain cells in people with Parkinson's disease. The drug also dissolved existing fibrils in laboratory tests.

29 Nov 2004

Discovery of gene mutation in fruit flies that alters sensitivity to crack cocaine

Researchers at the University of California, San Francisco (UCSF) and New York University have discovered a gene mutation in fruit flies that alters sensitivity to crack cocaine and also regulates their internal body clock.

23 Nov 2004

The brain's dopamine system is key to alcoholism

Among the many genes that may contribute to an individual's susceptibility to alcoholism, those in the dopamine system are of special interest because addictive substances can activate this system.

14 Nov 2004

New strain of mice to study nicotine addiction

A team of investigators supported by the National Institute on Drug Abuse (NIDA), National Institutes of Health, has created a strain of mice scientists can use to study nicotine addiction and its associated behaviors.

9 Nov 2004

Dopamine in the brain plays a key role in how we make choices

Researchers at the University of Colorado at Boulder studying Parkinson's disease patients found strong evidence that dopamine in the brain plays a key role in how people implicitly learn to make choices that lead to good outcomes, while avoiding bad ones.

8 Nov 2004

Body's 'internal marijuana': A new target for treatment of schizophrenia, Parkinson's?

“Endocannabinoids” is an impressive word that sounds like the name for a group of tribal warriors or an ancient people. Actually, it is the scientific term for beneficial molecules produced in the brain that act as “a sort of internal marijuana in our system

4 Nov 2004

alpha4 may prove to be useful target for smoking addiction therapies

Nicotine is responsible for more than four million smoking-related deaths each year. Yet people still smoke. Why? One reason is the stranglehold of addiction, started when nicotine enhances the release of a neurotransmitter called dopamine

4 Nov 2004