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AI scores breakthrough in anemia treatment with novel PHD inhibitor

Clinical stage generative artificial intelligence (AI)-driven biotechnology company InSilico Medicine ("InSilico"), today announced that the Journal of Medicinal Chemistry, an ACS Publications journal focusing on critical studies about molecular structure and biological activity, has published the company's discovery of a novel PHD inhibitor for the treatment of anemia.

19 Jan 2024

Neutrophils: Unraveling their multifaceted roles in inflammatory bowel disease and gut microbiota interactions

Research delves into the complex roles of neutrophils in inflammatory bowel disease (IBD), exploring their diverse functions and interactions with the gut microbiota and emphasizing the need for targeted therapies based on these insights.

27 Dec 2023

New combinations and targeted therapies for acute myeloid leukemia on the horizon

The treatment landscape for acute myeloid leukemia (AML) is evolving rapidly, as research discoveries at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and other academic cancer centers advance new, more effective therapies for this aggressive blood cancer.

11 Dec 2023

Study explores the intricate gut-brain-liver connection and its impact on health

Study reviews the gut-brain-liver axis, revealing the complex interplay between these organs in health and disease and the implications for therapeutic interventions, focusing on how gut microbiota affects liver and brain health.

10 Dec 2023

Using near-infrared spectroscopy to study how infant brains respond to touch

Researchers from Tokyo Metropolitan University have measured how oxygenated hemoglobin levels in the blood change in infants' brains in response to touch.

9 Dec 2023

New insights into the cellular programs that promote resolution of inflammation during aging

Aging is associated with chronic, nonresolving inflammation, or "inflammaging," that can lead to tissue dysfunction.

6 Dec 2023

Maternal exercise shapes early yolk sac growth, varies with baby's sex

This study in Scientific Reports reveals that maternal physical activity impacts yolk sac development in early pregnancy, with effects varying based on gestational age and the sex of the embryo, underscoring the nuanced relationship between maternal behavior and embryonic growth.

23 Nov 2023

Groundbreaking technology developed to extract mesenchymal stem cells from pure bone marrow

Researchers from the Critical Analytics for Manufacturing Personalized-Medicine (CAMP) Interdisciplinary Research Group (IRG) of Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, in collaboration with the Agency for Science, Technology and Research (A*STAR) Bioprocessing Technology Institute (BTI) and National University Health System (NUHS), have developed a groundbreaking technology capable of extracting mesenchymal stem cells (MSCs) directly from pure bone marrow – also known as bone marrow aspirate (BMA), a pivotal source of MSCs – without dilution.

20 Nov 2023

$13M NIH grant funds research to rejuvenate immune system in older adults

University of Arizona Health Sciences researchers received a $13.1 million grant from the National Institute on Aging to continue studies aimed at rejuvenating the immune system of older people in order to improve health throughout the lifespan.

1 Nov 2023

New implantable device carries insulin-producing islet cells to control diabetes

One promising approach to treating Type 1 diabetes is implanting pancreatic islet cells that can produce insulin when needed, which can free patients from giving themselves frequent insulin injections.

19 Sep 2023

Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling

Researchers describe molecular signalling regulated by mTOR among memory and exhausted cytotoxic CD8+ T lymphocytes.

18 Aug 2023

Thymus gland critical for adult health, study finds

The thymus gland-; which produces immune T cells before birth and during childhood-; is often regarded as nonfunctional in adults, and it's sometimes removed during cardiac surgery for easier access to the heart and major blood vessels.

2 Aug 2023

NK:IO raises £1.2M, bringing total Seed funding to £5.1M, to advance pioneering NK cell therapy

New investment of £1.2M brings total Seed funding to £5.1M including Innovate UK grants of £1.9M.

From NK:IO Limited 25 Jul 2023

Imperial spinout NK:IO awarded £1.6M Innovate UK New Cancer Therapeutics grant for development of pioneering NK cell therapy

NK:IO, a leader in NK cell biology applied to the development of exceptionally potent, off-the-shelf cell therapies targeting solid tumors, today announced it has been awarded £1.6M in grant funding from Innovate UK’s New Cancer Therapeutics program.

From NK:IO Limited 11 Jul 2023

Microparticle-delivered therapy likely to be the first step toward stopping autoimmune diseases

According to the federal government's National Institute of Neurological Disorders and Stroke, nearly 3 million people worldwide -; with almost a third in the United States -; are living with multiple sclerosis (MS), a disabling neurological disease in which the body's immune system mistakenly attacks nerves feeding information to the central nervous system (the brain and spinal cord). Although rarely fatal, MS can lead to long-term disabilities, and impair movement, muscle control, vision and cognition.

6 Jun 2023

Research opens door to new, more efficient drug combinations for acute myeloid leukemia

Acute myeloid leukemia (AML) is a very aggressive disease in which cells proliferate abnormally, invading the bone marrow and interfering with normal blood cell production. It is the most common acute leukemia in adults with the worst prognosis.

5 Jun 2023

Targeting stem cells from the human stomach for treating diabetes

Stem cells from the human stomach can be converted into cells that secrete insulin in response to rising blood sugar levels, offering a promising approach to treating diabetes, according to a preclinical study from researchers at Weill Cornell Medicine.

25 May 2023