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Researchers engineer water-soluble histidine kinase for enhanced antibiotic drug screens

A bacterial enzyme called histidine kinase is a promising target for new classes of antibiotics. However, it has been difficult to develop drugs that target this enzyme, because it is a "hydrophobic" protein that loses its structure once removed from its normal location in the cell membrane.

11 Jun 2024

Study reveals exploitation mechanism of virus-related nanoparticles for bacterial proliferation

Viruses are ubiquitous in the environment, and organisms have developed various mechanisms to counter their threat.

11 Jun 2024

Newcells Biotech strengthens executive and US team with key appointments

Dr Valeria Chichagova appointed as Director of Technology, Dr Colin Brown as Chief Scientific Officer, and Professor Lyle Armstrong as Scientific Advisor.

From Newcells Biotech 11 Jun 2024

Innovative blood test boosts accuracy of lung cancer screening

A blood-based, cell-free deoxyribonucleic acid (cfDNA) fragmentome assay for lung cancer detection.

11 Jun 2024

Wildfire smoke linked to over 52,000 premature deaths in California, study reveals

Research shows wildfire PM2.5 exposure caused over 52,000 premature deaths in California from 2008 to 2018, with significant economic impacts.

11 Jun 2024

Patient perspectives highlight urgent need for research on smell and taste disorders

Researchers and patient advocates from the Monell Chemical Senses Center, Smell and Taste Association of North America (STANA), and Thomas Jefferson University came together during the COVID-19 pandemic to incorporate patient voices in efforts to prioritize research areas focused on improving care for people with smell and taste disorders.

10 Jun 2024

Ashwagandha boosts memory and mood in clinical trial

A clinical trial found that acute and 30-day Ashwagandha supplementation improves cognitive function and mood markers, showing significant benefits in memory, attention, and well-being without adverse effects.

10 Jun 2024

Understanding Crohn's disease through 'mini-gut' models

Cambridge scientists have grown 'mini-guts' in the lab to help understand Crohn's disease, showing that 'switches' that modify DNA in gut cells play an important role in the disease and how it presents in patients.

10 Jun 2024

Innovative FAP-targeted radioligand therapy controls disease progression in sarcoma

Fibroblast activation protein (FAP)-targeted radioligand therapy is safe and effective for treating patients with progressive metastatic tumors, specifically advanced sarcomas, according to research presented at the 2024 Society of Nuclear Medicine and Molecular Imaging Annual Meeting.

10 Jun 2024

Transforming antibody drug discovery with Epitope Binning-seq

Monoclonal antibodies are crucial therapeutics due to their high specificity and binding affinity for epitopes (the precise sites where an antibody attaches itself to an antigen, triggering an immune response).

10 Jun 2024

Johns Hopkins researchers discover how epilepsy drug modulates brain activity

By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius -; nearly twice as cold as the coldest places in Antarctica -; scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.

10 Jun 2024

Transplanted gut microbes from aged mice trigger inflammation in young germ-free mice

When scientists transplanted the gut microbes of aged mice into young "germ-free" mice -; raised to have no gut microbes of their own -; the recipient mice experienced an increase in inflammation that parallels inflammatory processes associated with aging in humans.

10 Jun 2024

CSHL team identifies crucial protein interactions in RNA splicing process

Bodybuilders and cellular mechanisms agree generating protein is a heavy lift. To complete the task, cells rely on complexes called spliceosomes.

10 Jun 2024

Unveiling Pseudomonas aeruginosa's lung invasion tactics with human lung microtissues

How do pathogens invade the lungs? Using human lung microtissues, a team at the Biozentrum of the University of Basel has uncovered the strategy used by a dangerous pathogen.

10 Jun 2024

Efficient whole-gene insertions can be achieved with improved gene-editing technology

Scientists at the Broad Institute of MIT and Harvard have improved a gene-editing technology that is now capable of inserting or substituting entire genes in the genome in human cells efficiently enough to be potentially useful for therapeutic applications.

10 Jun 2024

Host RNA incorporation linked to chronic hepatitis E infection

If the virus incorporates host genetic segments into its genome, the infection may become chronic.

10 Jun 2024

Abnormal aortic blood in the aorta flow linked to vessel wall inflammation and breakdown

Abnormal blood flow in the aorta is linked to inflammation and breakdown of the vessel wall in conditions where the aorta is dilated.

10 Jun 2024

How Epstein-Barr virus shapes immune responses in multiple sclerosis

Study found that EBV-specific immune responses in MS patients showed higher IgG titers and cell-mediated reactions to EBV antigens compared to healthy controls, suggesting a complex role of EBV in MS development.

9 Jun 2024

Experts call for clear rules governing human embryo research

Clear rules governing human embryo research must be established to enable regulators, researchers and funders to assess whether stem cell-generated models should be considered as human embryos, two leading experts from The University of Manchester have argued.

8 Jun 2024

Novel Concepts Medical's plant-based formula achieves 99% reduction in cancer cell viability

Novel Concepts Medical is proud to announce breakthrough results from its labs in Israel showing that its plant-based formula resulted in over 99% decrease in cell viability of breast cancer cells and lung cancer cells.

8 Jun 2024

Cell News and Research

Researchers engineer water-soluble histidine kinase for enhanced antibiotic drug screens

Study reveals exploitation mechanism of virus-related nanoparticles for bacterial proliferation

Newcells Biotech strengthens executive and US team with key appointments

Innovative blood test boosts accuracy of lung cancer screening

Wildfire smoke linked to over 52,000 premature deaths in California, study reveals

Patient perspectives highlight urgent need for research on smell and taste disorders

Ashwagandha boosts memory and mood in clinical trial

Understanding Crohn's disease through 'mini-gut' models

Innovative FAP-targeted radioligand therapy controls disease progression in sarcoma

Transforming antibody drug discovery with Epitope Binning-seq

Johns Hopkins researchers discover how epilepsy drug modulates brain activity

Transplanted gut microbes from aged mice trigger inflammation in young germ-free mice

CSHL team identifies crucial protein interactions in RNA splicing process

Unveiling Pseudomonas aeruginosa's lung invasion tactics with human lung microtissues

Efficient whole-gene insertions can be achieved with improved gene-editing technology

Host RNA incorporation linked to chronic hepatitis E infection

Abnormal aortic blood in the aorta flow linked to vessel wall inflammation and breakdown

How Epstein-Barr virus shapes immune responses in multiple sclerosis

Experts call for clear rules governing human embryo research

Novel Concepts Medical's plant-based formula achieves 99% reduction in cancer cell viability

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

Breathing New Life into Diagnostics: Plasmion's SICRIT Technology

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