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Breakthrough study reveals role of histone deacetylases in inflammatory bowel disease

In a scientific breakthrough, Mount Sinai researchers have revealed the biological mechanisms by which a family of proteins known as histone deacetylases (HDACs) activate immune system cells linked to inflammatory bowel disease (IBD) and other inflammatory diseases.

22 Apr 2024

Study explores the effects of ovulation inducing method on embryo quality

Low birth rates have become a serious problem in many developed countries throughout the world, with Japan being a prime example. In Japan particularly, aging and stress have led to a massive rise in infertility, which now affects one in every 4.4 couples.

22 Apr 2024

Liver cells effectively serve as immune checkpoint regulating anti-cancer immunity

Liver inflammation, a common side-effect of cancers elsewhere in the body, has long been associated with worse cancer outcomes and more recently associated with poor response to immunotherapy.

22 Apr 2024

Study explores tocotrienols' neuroprotective effects in obesity-related cognitive decline

Obesity has become a pressing worldwide health issue, with rates steadily rising over recent decades.

18 Apr 2024

Study identifies genomic variant linked to unique human skull base morphology

Humans, Homo sapiens, have unique features compared with other closely related hominin species and primates, including the shape of the base of the skull.

17 Apr 2024

Exploring how gene variants affect brain cells in children with severe epilepsy

Epilepsy is a brain disorder that causes recurring seizures.

16 Apr 2024

U-M study reveals potential pathway to reverse lung fibrosis

The most common type of lung fibrosis -; scarring of the lungs -- is idiopathic, meaning of unknown cause.

13 Apr 2024

Link between aldehydes and premature aging revealed

A team of researchers at Nagoya University in Japan has discovered that aldehydes are metabolic byproducts associated with premature aging.

12 Apr 2024

Researchers create novel drug that can prevent flu-induced lung injury

Infection with the influenza virus leads to lung injury through inflammation over-activation that causes collateral damage to cells required for breathing.

10 Apr 2024

CNIC researchers unravel complexities of Andersen-Tawil syndrome

A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has made a breakthrough discovery in the understanding of cardiac arrhythmias by unraveling the complexities of Andersen-Tawil syndrome (ATS), an extremely rare inherited cardiac disorder.

10 Apr 2024

Novel immune cell therapy may be a promising strategy for combating HBV infection

Chronic infection with the hepatitis B virus (HBV) causes progressive liver problems, and eradication of the virus remains a formidable challenge.

10 Apr 2024

CMS121 holds promise for treating metabolic diseases

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 6, entitled, "CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction."

9 Apr 2024

Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems -; prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia.

9 Apr 2024

Researchers elucidate how gene mutation mechanism causes autism

Researchers show how mutations of gene transcription and chromatin regulation-related genes cause autism.

9 Apr 2024

Obesity and high-fat diets linked to accelerated aging in brain blood vessels

A new study conducted in mice traces how obesity and a high-fat diet may accelerate aging in the blood vessels that supply blood to the brain.

7 Apr 2024

Discovery of a fundamental biological mechanism opens path for novel therapies

The lab of Yongchao C. Ma, PhD, at Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago discovered a fundamental biological mechanism that could lead to new treatments for neurological diseases, such as spinal muscular atrophy (SMA) and autism, as well as different cancers.

4 Apr 2024

Interferon-beta deficiency alters brain response in neuroHIV mouse model

NeuroHIV refers to the effects of HIV infection on the brain or central nervous system and, to some extent, the spinal cord and peripheral nervous system.

4 Apr 2024

Newly discovered cause for asthma sparks hope for treatment

Scientists at King's College London have discovered a new cause for asthma that sparks hope for treatment that could prevent the life-threatening disease.

4 Apr 2024

Anti-inflammatory therapy shows promise to treat patients following acute myocardial infarction

Research into the protective effects of two anti-inflammatory molecules, transforming growth factor-beta1 (TGFβ1) and Heligmosomoides polygyrus TGM (HpTGM), following heart attack found that both proteins reduced the inflammatory response within the injured heart and reduced mature scarring.

4 Apr 2024

JAX researchers develop a powerful platform to study human health conditions

In humans, the exact same mutation in a specific gene can produce widely different outcomes. It's a bit like adding the same amount of salt to different recipes-;the effect on the finished dish can be quite different, depending on the mix of other ingredients.

3 Apr 2024