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Evaluating the efficacy of harmol in treating herpes simplex virus-induced keratitis

The antiviral efficacy and therapeutic potential of harmol in treating herpes simplex virus type 1 (HSV-1) induced keratitis

29 May 2024

Tailoring polymeric micelles for improved olaparib solubility and drug release

Olaparib is a selective poly (ADP-ribose) polymerase inhibitor. However, its clinical application is hindered by low solubility and undesired pharmacokinetic profiles (e.g., relatively short circulation).

23 May 2024

New chemical modification improves effectiveness and safety of ASO therapy for CNS diseases

Diseases that affect the brain and spinal cord can be particularly devastating, and finding new and more effective ways to treat these conditions is an important goal for researchers and clinicians alike.

23 May 2024

Understanding the role of oxidative stress in Alzheimer's disease pathogenesis

The number of people suffering from Alzheimer's disease (AD) is expected to reach 100 million by 2050, but there is still no effective therapy.

21 May 2024

Matcha green tea powder may help keep gum disease bacteria at bay

Periodontitis is an inflammatory gum disease driven by bacterial infection and left untreated it can lead to complications including tooth loss.

21 May 2024

Groundbreaking study advances human in vitro gametogenesis for infertility treatment

Infertility affects approximately 1 in 6 people in their lifetime worldwide according to the World Health Organization (WHO).

21 May 2024

Treating obesity using glucagon-like peptide-1-directed N-methyl-D-aspartate receptor inhibition

Bimodal drug that successfully cures obesity, hyperglycemia, and dyslipidemia in mouse models.

20 May 2024

Unveiling the role of neutrophils in lung cancer progression

Lung cancer remains a leading global health concern, responsible for the highest number of cancer-related deaths worldwide.

16 May 2024

Mechanistic insights into the role of huc-mscs in treating acute liver failure

Acute liver failure (ALF) is a life-threatening clinical problem with limited treatment options. Administration of human umbilical cord mesenchymal stem cells (hUC-MSCs) may be a promising approach for ALF.

16 May 2024

New study finds Sfrp1 as a potential therapeutic target in cancer treatment

Cancer is a leading cause of death globally. One of the primary reasons why cancer is such a deadly disease is the ability of cancer cells to become drug-resistant.

15 May 2024

Menthol-derived molecules: promising candidates for anti-inflammatory and anti-obesity therapy

Modified derivatives of natural products have led to significant therapeutic advances and commercial success in recent times.

15 May 2024

Understanding public perception of polygenic embryo screening for IVF

Three out of four U.S. adults support the use of emerging technologies that estimate a future child's likelihood of developing health conditions influenced by multiple genes -; such as diabetes, heart disease, and depression -; before an embryo is implanted during in vitro fertilization (IVF), according to a new public opinion survey led by researchers at Harvard Medical School.

15 May 2024

New study reveals brain clearance of toxins is reduced during sleep and anesthesia

The adipose-neural axis plays an important role in arrhythmogenesis.

15 May 2024

Interactions between adipose and sympathetic neurons contribute to cardiac arrhythmia

A study in Cell Reports Medicine used an in vitro co-culture of adipocytes, cardiomyocytes, and sympathetic neurons to reveal that the adipose-neural axis plays a crucial role in arrhythmogenesis, driven by interactions between epicardial adipose tissue and the sympathetic nervous system.

14 May 2024

Study proposes a novel therapeutic avenue for tackling EHF-induced cholangiocarcinogenesis

This study is led by Dr. Yiming Luo (Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology) and Professor. Huifang Liang (Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology).

14 May 2024

Perspective delves into the rising threat of the MPX virus

Scientist at NIAID reviews the escalating global prevalence of the MPX virus, detailing its biology and transmission modes, and the urgent need for comprehensive research to understand and control its spread effectively.

13 May 2024

Democrats seek to make GOP pay for threats to reproductive rights

Democrat Lucas Kunce is trying to pin reproductive care restrictions on Sen. Josh Hawley (R-Mo.), betting it will boost his chances of unseating the incumbent in November.

10 May 2024

Drug repurposing breakthrough: varespladib curbs snakebite-induced necrosis

Researchers discovered that venom toxins from African spitting cobras cause severe dermonecrosis, highlighting the need for targeted treatments like the repurposed drug varespladib.

9 May 2024

Study uncovers alcohol's damaging effects on brain cells through oxidative stress

Alcohol exposure leads to accumulation of oxidatively damaged proteins in neuronal cells. Differentiated cells are more susceptible to alcohol-induced oxidative protein damage despite higher resistance to cytotoxicity.

9 May 2024

Enhancing the ability of natural killer cells to combat hematologic malignancies

A new study reveals a groundbreaking approach to immunotherapy, demonstrating that blocking the interaction between the CD300A receptor and phosphatidylserine (PS) significantly enhances the ability of human natural killer (NK) cells to lyse hematologic malignancies (HMs).

9 May 2024

in vitro News and Research

Evaluating the efficacy of harmol in treating herpes simplex virus-induced keratitis

Tailoring polymeric micelles for improved olaparib solubility and drug release

New chemical modification improves effectiveness and safety of ASO therapy for CNS diseases

Understanding the role of oxidative stress in Alzheimer's disease pathogenesis

Matcha green tea powder may help keep gum disease bacteria at bay

Groundbreaking study advances human in vitro gametogenesis for infertility treatment

Treating obesity using glucagon-like peptide-1-directed N-methyl-D-aspartate receptor inhibition

Unveiling the role of neutrophils in lung cancer progression

Mechanistic insights into the role of huc-mscs in treating acute liver failure

New study finds Sfrp1 as a potential therapeutic target in cancer treatment

Menthol-derived molecules: promising candidates for anti-inflammatory and anti-obesity therapy

Understanding public perception of polygenic embryo screening for IVF

New study reveals brain clearance of toxins is reduced during sleep and anesthesia

Interactions between adipose and sympathetic neurons contribute to cardiac arrhythmia

Study proposes a novel therapeutic avenue for tackling EHF-induced cholangiocarcinogenesis

Perspective delves into the rising threat of the MPX virus

Democrats seek to make GOP pay for threats to reproductive rights

Drug repurposing breakthrough: varespladib curbs snakebite-induced necrosis

Study uncovers alcohol's damaging effects on brain cells through oxidative stress

Enhancing the ability of natural killer cells to combat hematologic malignancies

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

Sensing a Healthier Future

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