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DoD grant awarded for investigating alternative polyadenylation in prostate cancer

A team led by Dr. Eddie Imada, assistant professor of research in pathology and laboratory medicine, has been awarded a three-year, $1.5 million United States Department of Defense grant for research on a cellular process called alternative polyadenylation and its role in prostate cancer.

10 May 2024

Researchers discover a 'training program' driving parietal cell development

Common conditions such as indigestion and heartburn as well as peptic ulcers, autoimmune gastritis and stomach and esophageal cancers have one thing in common – they involve disruptions of the normal activity of parietal cells (PCs) in the stomach, the only cells in the body that produce acid.

10 May 2024

The power of mixed selectivity: Insights into brain function and cognition

Every day our brains strive to optimize a trade-off: With lots of things happening around us even as we also harbor many internal drives and memories, somehow our thoughts must be flexible yet focused enough to guide everything we have to do.

10 May 2024

Understanding the metabolic changes from birth to diagnosis of autism

Researchers at the University of California San Diego School of Medicine have shed new light on the changes in metabolism that occur between birth and the presentation of autism spectrum disorder (ASD) later in childhood.

10 May 2024

A previously unknown post-COVID syndrome found

Pradipta Ghosh, M.D., sat down in her office at the University of California San Diego School of Medicine and considered a request from the other side of the world.

9 May 2024

AML patients at the extremes of older age derive benefit from VEN-HMA regimen

Standard of care treatment for acute myeloid leukemia (AML) is safe and effective for adults over 80, according to a study published in Blood Neoplasia. For roughly a quarter of patients, this treatment can durably prolong survival.

9 May 2024

New study reveals key cells regulating fat tissue formation

Understanding how fat tissue forms and functions is crucial for addressing obesity and related metabolic diseases. However, adipose tissue, or body fat, behaves differently based on its location in the body.

9 May 2024

Breakthrough research offers promise for developing new immune therapies for cancer

Scientists from Trinity College Dublin have made an important breakthrough that offers promise for developing new immune therapies for cancer.

9 May 2024

Drug repurposing breakthrough: varespladib curbs snakebite-induced necrosis

Researchers discovered that venom toxins from African spitting cobras cause severe dermonecrosis, highlighting the need for targeted treatments like the repurposed drug varespladib.

9 May 2024

Breakthrough vaccine strategy guides the immune system to generate HIV neutralizing antibodies

A team led by the Duke Human Vaccine Institute (DHVI) has developed a vaccine approach that works like a GPS, guiding the immune system through the specific steps to make broadly neutralizing antibodies against HIV.

9 May 2024

Researchers create the largest 3D reconstruction of human brain fragment

A cubic millimeter of brain tissue may not sound like much. But considering that tiny square contains 57,000 cells, 230 millimeters of blood vessels, and 150 million synapses, all amounting to 1,400 terabytes of data, Harvard and Google researchers have just accomplished something enormous.

9 May 2024

Combination immunotherapy treatment enhances immune response for people with malignant gliomas

Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an aggressive type of brain tumor that is fast growing and difficult to treat.

9 May 2024

Experts identify highly drug-resistant infections from stem cell treatments In Mexico

Experts in mycobacterial diseases at National Jewish Health, in collaboration with local health departments and the Centers for Disease Control and Prevention (CDC), are investigating a potential outbreak of a highly drug-resistant mycobacterium (germ) after U.S. patients who traveled to Mexico for stem cell injections became sick.

9 May 2024

Ketogenic diet a potential therapy for autism by reshaping gut bacteria and brain inflammation

Modified ketogenic diet modulates gut microbiome, inflammatory markers, and brain-related miRNAs in autistic children, correlating with improved behavioral symptoms. The diet increases beneficial gut bacteria and reduces inflammatory cytokines and BDNF levels.

9 May 2024

Study uncovers alcohol's damaging effects on brain cells through oxidative stress

Alcohol exposure leads to accumulation of oxidatively damaged proteins in neuronal cells. Differentiated cells are more susceptible to alcohol-induced oxidative protein damage despite higher resistance to cytotoxicity.

9 May 2024

Study examines association between neighborhood disadvantage and DNA methylation in brain tissue

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, "The association between neighborhood deprivation and DNA methylation in an autopsy cohort."

9 May 2024

Mouse-rat chimeras offer functional liver cells for transplantation

Liver disease, due to viral infections, alcohol abuse, obesity, or cancer, accounts for 1 in every 25 deaths worldwide.

9 May 2024

Deep learning models for predicting prostate cancer recurrence risk from 3D pathology datasets

Human tissue is intricate, complex and, of course, three dimensional. But the thin slices of tissue that pathologists most often use to diagnose disease are two dimensional, offering only a limited glimpse at the tissue's true complexity.

9 May 2024

Exploring microbiome dynamics in esophageal cancer

Esophageal cancer (EC) has two primary subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC).

9 May 2024

Enhancing the ability of natural killer cells to combat hematologic malignancies

A new study reveals a groundbreaking approach to immunotherapy, demonstrating that blocking the interaction between the CD300A receptor and phosphatidylserine (PS) significantly enhances the ability of human natural killer (NK) cells to lyse hematologic malignancies (HMs).

9 May 2024

Cell News and Research

DoD grant awarded for investigating alternative polyadenylation in prostate cancer

Researchers discover a 'training program' driving parietal cell development

The power of mixed selectivity: Insights into brain function and cognition

Understanding the metabolic changes from birth to diagnosis of autism

A previously unknown post-COVID syndrome found

AML patients at the extremes of older age derive benefit from VEN-HMA regimen

New study reveals key cells regulating fat tissue formation

Breakthrough research offers promise for developing new immune therapies for cancer

Drug repurposing breakthrough: varespladib curbs snakebite-induced necrosis

Breakthrough vaccine strategy guides the immune system to generate HIV neutralizing antibodies

Researchers create the largest 3D reconstruction of human brain fragment

Combination immunotherapy treatment enhances immune response for people with malignant gliomas

Experts identify highly drug-resistant infections from stem cell treatments In Mexico

Ketogenic diet a potential therapy for autism by reshaping gut bacteria and brain inflammation

Study uncovers alcohol's damaging effects on brain cells through oxidative stress

Study examines association between neighborhood disadvantage and DNA methylation in brain tissue

Mouse-rat chimeras offer functional liver cells for transplantation

Deep learning models for predicting prostate cancer recurrence risk from 3D pathology datasets

Exploring microbiome dynamics in esophageal cancer

Enhancing the ability of natural killer cells to combat hematologic malignancies

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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