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More than 20,000 volunteers join effort to accelerate dementia drug development

More than 20,000 volunteers have been recruited to a resource aimed at speeding up the development of much-needed dementia drugs. The cohort will enable scientists in universities and industry to involve healthy individuals in clinical trials to test whether new drugs can slow the decline in various brain functions including memory and delay the onset of dementia.

15 May 2024

St. Jude researchers unveil mechanisms to block PXR and enhance drug potency

Deaths from cancer or infections can occur when available treatments are ineffective. Once turned on, pregnane X receptor (PXR) activates the expression of genes encoding enzymes that metabolize external chemicals, including drugs.

14 May 2024

Innovative 'mini-brains' could revolutionize Alzheimer's diagnosis and treatment

Using an innovative new method, a University of Saskatchewan (USask) researcher is building tiny pseudo-organs from stem cells to help diagnose and treat Alzheimer's.

14 May 2024

Pharmacological treatment reduces specific crimes in adolescents with ADHD

A study in the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP), published by Elsevier, found that pharmacological treatment of attention-deficit/hyperactivity disorder (ADHD) reduced violence- and public-order related crimes.

14 May 2024

Human cell-based model of thoracic aortic aneurysm offers new opportunities for drug development

Using human cells in laboratory rats, Michigan Medicine researchers have developed a functional model of thoracic aortic aneurysm, creating opportunities for more effective understanding of disease development and treatments for the potentially fatal condition, a study suggests.

14 May 2024

Racial and ethnic disparities in Alzheimer's diagnosis and CNS drug prescription

Compared to Black and Asian people, white and Hispanic people with Alzheimer's disease and related dementias were most likely to be diagnosed with symptoms like depression and agitation, according to a new study from the USC Schaeffer Center for Health Policy & Economics.

14 May 2024

Investigational drug shows promise in increasing oxygen uptake for patients with heart condition

People with a common heart condition were able to use significantly more oxygen while exercising after taking an investigational drug in an international clinical trial, according to a study published today in the New England Journal of Medicine.

14 May 2024

Study reveals unintended consequences of antibiotic choice in sepsis treatment

In emergency rooms and intensive care units across the country, clinicians make split-second decisions about which antibiotics to give a patient when a life-threatening infection is suspected.

14 May 2024

Clinical trial in Seattle aims to transform treatment approaches for pediatric IBD

With pediatric inflammatory bowel disease (IBD) diagnoses on the rise globally, a clinical trial in Seattle aims to transform treatment approaches through deep molecular profiling.

14 May 2024

Unraveling the genetic connection between IBD and Parkinson's disease

Researchers at the Icahn School of Medicine at Mount Sinai have made a significant discovery, identifying genetic connections between inflammatory bowel disease (IBD) and Parkinson's disease (PD).

14 May 2024

Exploring how intense ultrasound can release biological indicators of disease

Ultrasound imaging offers a valuable and noninvasive way to find and monitor cancerous tumors. However, much of the most crucial information about a cancer, such as specific cell types and mutations, cannot be learned from imaging and requires invasive and damaging biopsies.

14 May 2024

PlaqueTec and the Babraham Institute collaborate on early phase target discovery and development

Campus Innovation Award (CIA)-funded project evaluated lead compounds predicted to bind a pro-inflammatory protein discovered by PlaqueTec

From PlaqueTec 14 May 2024

Metabolomic analysis sheds light on gut microbes' role in cardiovascular disease risk

The effect of gut bacteria on non-high-density lipoprotein cholesterol (non-HDL-c) variations.

14 May 2024

Protein mechanics key to cell nucleus entry, study finds

Researchers at the Francis Crick Institute and King's College London have discovered that how soft or rigid proteins are in certain regions can dictate how fast or slow they enter the nucleus.

13 May 2024

RAND report: Hospital prices surge above Medicare rates in 2022

Prices paid to hospitals during 2022 by employers and private insurers for both inpatient and outpatient services averaged 254% of what Medicare would have paid, with wide variation in prices among states, according to a new RAND report.

13 May 2024

Mail delivery of abortion pills is safe and convenient, study shows

Dispensing abortion pills through the mail works as well as requiring patients to get them in person from a clinic or doctor's office, according to new research from UC San Francisco, which comes as the Supreme Court is considering whether to disallow the practice.

13 May 2024

Research unlocks the role of macrophages in cancer relapse

Researchers from the Cancer Science Institute of Singapore at the National University of Singapore (NUS), have achieved breakthroughs in understanding relapse after chemotherapy for a type of cancer known as diffuse large B-cell lymphoma (DLBCL).

13 May 2024

Study reveals sharp surge in illicit fentanyl seizures

The number of illicit fentanyl seizures by law enforcement in the United States grew by more than 1,700 percent between 2017 and 2023, according to a new analysis.

13 May 2024

San Francisco tries tough love by tying welfare to drug rehab

Raymond Llano carries a plastic bag with everything he owns in one hand, a cup of coffee in the other, and the flattened cardboard box he uses as a bed under his arm as he waits in line for lunch at Glide Memorial Church in San Francisco. At 55, he hasn't had a home for 15 years, since he lost a job at Target.

13 May 2024

First responders, veterans hail benefits of psychedelic drugs as California debates legalization

Wade Trammell recalls the time he and his fellow firefighters responded to a highway crash in which a beer truck rammed into a pole, propelling the truck's engine through the cab and into the driver's abdomen.

13 May 2024

Drugs News and Research

More than 20,000 volunteers join effort to accelerate dementia drug development

St. Jude researchers unveil mechanisms to block PXR and enhance drug potency

Innovative 'mini-brains' could revolutionize Alzheimer's diagnosis and treatment

Pharmacological treatment reduces specific crimes in adolescents with ADHD

Human cell-based model of thoracic aortic aneurysm offers new opportunities for drug development

Racial and ethnic disparities in Alzheimer's diagnosis and CNS drug prescription

Investigational drug shows promise in increasing oxygen uptake for patients with heart condition

Study reveals unintended consequences of antibiotic choice in sepsis treatment

Clinical trial in Seattle aims to transform treatment approaches for pediatric IBD

Unraveling the genetic connection between IBD and Parkinson's disease

Exploring how intense ultrasound can release biological indicators of disease

PlaqueTec and the Babraham Institute collaborate on early phase target discovery and development

Metabolomic analysis sheds light on gut microbes' role in cardiovascular disease risk

Protein mechanics key to cell nucleus entry, study finds

RAND report: Hospital prices surge above Medicare rates in 2022

Mail delivery of abortion pills is safe and convenient, study shows

Research unlocks the role of macrophages in cancer relapse

Study reveals sharp surge in illicit fentanyl seizures

San Francisco tries tough love by tying welfare to drug rehab

First responders, veterans hail benefits of psychedelic drugs as California debates legalization

Drug Discovery - Second Edition eBook

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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