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New study uncovers 17 genes driving clonal hematopoiesis and links to aging and disease

Researchers identified 17 new genes positively selected for clonal hematopoiesis in a large U.K. Biobank cohort, revealing their impact on aging and disease risks.

15 May 2024

Expanding treatment horizons for hypermutated urothelial carcinomas beyond immunotherapy

A new editorial paper was published in Oncoscience (Volume 11) on April 25, 2024, entitled, "Therapeutic opportunities for hypermutated urothelial carcinomas beyond immunotherapy."

10 May 2024

AML patients at the extremes of older age derive benefit from VEN-HMA regimen

Standard of care treatment for acute myeloid leukemia (AML) is safe and effective for adults over 80, according to a study published in Blood Neoplasia. For roughly a quarter of patients, this treatment can durably prolong survival.

9 May 2024

Breakthrough vaccine strategy guides the immune system to generate HIV neutralizing antibodies

A team led by the Duke Human Vaccine Institute (DHVI) has developed a vaccine approach that works like a GPS, guiding the immune system through the specific steps to make broadly neutralizing antibodies against HIV.

9 May 2024

New clinical guideline released for effectively managing individuals with hypertrophic cardiomyopathy

The American College of Cardiology (ACC) and the American Heart Association (AHA) today released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy (HCM).

8 May 2024

Gene linked to intellectual disability can regulate learning and memory

A gene previously linked to intellectual disability has been found to regulate learning and memory in mice.

8 May 2024

Amgen plows ahead with costly, highly toxic cancer dosing despite FDA challenge

When doctors began using the drug sotorasib in 2021 with high expectations for its innovative approach to attacking lung cancer, retired medical technician Don Crosslin was an early beneficiary.

7 May 2024

Vitamin D receptor polymorphism found to influence COVID-19 severity

Researchers compared SNPs in the vitamin D receptor (VDR) gene between mild and severe COVID-19 patients.

7 May 2024

Rutgers scientists create CRISPR-edited mice to study the neurobiology of Tourette disorder

In research that may be a step forward toward finding personalized treatments for Tourette disorder, scientists at Rutgers University–New Brunswick have bred mice that exhibit some of the same behaviors and brain abnormalities seen in humans with the disorder.

6 May 2024

CRISPR-based gene editing shows promise in treating rare form of blindness

About 79% of clinical trial participants experienced measurable improvement after receiving experimental, CRISPR-based gene editing that is designed to fix a rare form of blindness, according to a paper published in the New England Journal of Medicine.

6 May 2024

CRISPR gene editing shows promise for treating individuals with a form of inherited blindness

Results from a groundbreaking clinical trial of CRISPR gene editing in 14 individuals with a form of inherited blindness show that the treatment is safe and led to measurable improvements in 11 of the participants treated.

6 May 2024

First FDA-approved cellular therapy for metastatic melanoma available in South Florida

Patients in South Florida with metastatic melanoma will soon have access to the first cellular therapy for this advanced form of skin cancer, following its recent approval by the Food and Drug Administration (FDA).

2 May 2024

Cancer-like cells found in clogged arteries aggravate atherosclerosis

Columbia University researchers have found cells inside clogged arteries share similarities with cancer and aggravate atherosclerosis, raising the possibility that anticancer drugs could be used to treat atherosclerosis and prevent heart attacks.

1 May 2024

ZIP7: A novel target for treating degenerative diseases associated with misfolded proteins

Proteins are the workhorses of life. Organisms use them as building blocks, receptors, processors, couriers and catalysts.

30 Apr 2024

RNA editing using CRISPRs shows promise for genetic disease treatment

A team at Montana State University published research this week that shows how RNA, the close chemical cousin to DNA, can be edited using CRISPRs.

29 Apr 2024

SCA4 genetic breakthrough: Unveiling the cause of a devastating neurological disease

Some families call it a trial of faith. Others just call it a curse. The progressive neurological disease known as spinocerebellar ataxia 4 (SCA4) is a rare condition, but its effects on patients and their families can be severe.

29 Apr 2024

Study rethinks immune system strategies to boost vaccine effectiveness

A recent Cell journal review explores key immunological assumptions to enhance our understanding of vaccine design, autoimmune responses, and immune system pathology, aiming to refine intervention strategies and theoretical frameworks in immunology.

28 Apr 2024

Single dose of malaria monoclonal antibody 77% effective in children, trial in Mali shows

One injected dose of an experimental malaria monoclonal antibody was 77% effective against malaria disease in children in Mali during the country's six-month malaria season, according to the results of a mid-stage clinical trial.

26 Apr 2024

New tARC-seq method enhances precision in tracking SARS-CoV-2 mutations

A tARC-seq approach to precisely determine SARS-CoV-2 mutation frequency.

24 Apr 2024

Study discovers hidden mechanism behind rapid COVID variants

The SARS-CoV-2 virus that causes COVID has the unsettling ability of often generating variants of itself. Other viruses also mutate, but as SARS-CoV-2 quickly spread throughout the entire human population during the pandemic, killing millions, the virus' dynamic evolution posed a serious problem: it repeatedly challenged our bodies' immune response fighting the virus and hindered the process of getting updated vaccines ready.

23 Apr 2024

Mutation News and Research

New study uncovers 17 genes driving clonal hematopoiesis and links to aging and disease

Expanding treatment horizons for hypermutated urothelial carcinomas beyond immunotherapy

AML patients at the extremes of older age derive benefit from VEN-HMA regimen

Breakthrough vaccine strategy guides the immune system to generate HIV neutralizing antibodies

New clinical guideline released for effectively managing individuals with hypertrophic cardiomyopathy

Gene linked to intellectual disability can regulate learning and memory

Amgen plows ahead with costly, highly toxic cancer dosing despite FDA challenge

Vitamin D receptor polymorphism found to influence COVID-19 severity

Rutgers scientists create CRISPR-edited mice to study the neurobiology of Tourette disorder

CRISPR-based gene editing shows promise in treating rare form of blindness

CRISPR gene editing shows promise for treating individuals with a form of inherited blindness

First FDA-approved cellular therapy for metastatic melanoma available in South Florida

Cancer-like cells found in clogged arteries aggravate atherosclerosis

ZIP7: A novel target for treating degenerative diseases associated with misfolded proteins

RNA editing using CRISPRs shows promise for genetic disease treatment

SCA4 genetic breakthrough: Unveiling the cause of a devastating neurological disease

Study rethinks immune system strategies to boost vaccine effectiveness

Single dose of malaria monoclonal antibody 77% effective in children, trial in Mali shows

New tARC-seq method enhances precision in tracking SARS-CoV-2 mutations

Study discovers hidden mechanism behind rapid COVID variants

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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