Hepatology News and Research

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Hepatology is the branch of medicine that incorporates study of liver, gallbladder, biliary tree and pancreas as well as management of their disorders.

Small vesicles released by intestinal bacteria induce immune activation and progression of liver cirrhosis

Researchers from Niigata University and Kyoto Prefectural University have revealed that small vesicles, around 100 nm in size, released by intestinal bacteria induce immune activation and progression of liver cirrhosis, as well as reduction of serum albumin level, subsequently leading to edema and ascites.

19 Apr 2023

Unexpected discovery could inspire new strategies for preventing liver disease and cancer

Liver cancer is the third leading cause of cancer death and the sixth most common cancer type worldwide.

12 Apr 2023

ChatGPT can help empower patients and improve health literacy for different populations

A new study by Cedars-Sinai investigators describes how ChatGPT, an artificial intelligence (AI) chatbot, may help improve health outcomes for patients with cirrhosis and liver cancer by providing easy-to-understand information about basic knowledge, lifestyle and treatments for these conditions.

7 Apr 2023

Study illuminates how patients with variants in the PTPN2 gene develop IBD

Inflammatory bowel disease, or IBD, describes Crohn's disease and ulcerative colitis, two chronic diseases that cause inflammation in the intestines. IBD, which affects about 3 million adults in the United States, is an autoimmune disorder -; a condition in which the body's immune system attacks healthy tissues.

7 Apr 2023

New imaging technique can improve the treatment of intestinal strictures in Crohn's disease

Patients suffering from Crohn's disease, a chronic inflammatory intestinal disorder, develop painful constrictions in the bowel.

5 Apr 2023

AI chatbot may help improve health outcomes for patients with cirrhosis and liver cancer

31 Mar 2023

Study shows how many HBeAg-negative patients can achieve permanent immune control of hepatitis B

More than half of patients who suffer from chronic hepatitis B have the e antigen (HBeAg)-negative form of the disease.

30 Mar 2023

Study: Efforts to track HIV and HCV incidence among people who inject drugs need to be intensified

Countries must intensify efforts to track HIV and hepatitis C virus (HCV) incidence among people who inject drugs, and to prioritize this group in prevention and elimination work, according to new University of Bristol-led research, published online in The Lancet Gastroenterology & Hepatology.

28 Mar 2023

Real-world studies show efficacy, safety of BLV monotherapy in patients with HDV-related compensated cirrhosis

In 2020, bulevirtide (BLV) was conditionally approved for treating chronic hepatitis delta (CHD), an inflammation of the liver caused by hepatitis D virus (HDV).

20 Mar 2023

Usefulness of dried blood spot samples for monitoring HCV infection in people who inject drugs

A study with people who inject drugs evaluated a minimally invasive test based on dried blood spots (DBS) for the monitoring of hepatitis C virus (HCV) infection.

17 Mar 2023

Purine metabolite xanthine may play a role in Th17 cell differentiation in the gut

The gut is home to a cast of microbes that influence health and disease. Some types of microorganisms are thought to contribute to the development of inflammatory conditions, such as inflammatory bowel disease (IBD), but the exact cascade of events that leads from microbes to immune cells to disease remains mysterious.

16 Mar 2023

Vitamin A-rich diet may reduce risk of developing asparaginase-associated pancreatitis in ALL patients

Consuming a diet rich in vitamin A or its analogs may help prevent children and young adults with acute lymphoblastic leukemia (ALL) reduce their risk of developing painful pancreas inflammation during chemotherapy treatment.

15 Mar 2023

Redoubling efforts to highlight the importance of colorectal cancer screening

With the arrival of March, Colorectal Cancer Awareness Month, faculty and staff in the Department of Internal Medicine's Section of Digestive Diseases are redoubling their efforts to spread the word about the importance of screening, especially in younger individuals and those with a family history of the disease.

10 Mar 2023

FDA mandate to limit the dosage of acetaminophen linked to reductions in serious liver injury

A United States Food and Drug Administration mandate to limit the dosage of acetaminophen in pills that combine acetaminophen and opioid medications is significantly associated with subsequent reductions in serious liver injury, according to a study led by investigators at the University of Alabama and Weill Cornell Medicine.

7 Mar 2023

Gut bacteria influence the liver's regenerative ability

When parts of the liver are removed, the body can replace the missing tissue. A team of researchers at the Technical University of Munich has now discovered that the success of this process depends to a large extent on gut bacteria.

1 Mar 2023

Cutting just one food from the diet rather than six may help treat eosinophilic esophagitis

Eliminating animal milk alone from the diet of adults with eosinophilic esophagitis, or EoE, is as effective at treating the disease as eliminating animal milk plus five other common foods, a clinical trial funded by the National Institutes of Health has found.

27 Feb 2023

Adverse muscle composition can predict mortality risk in people with fatty liver disease

Obesity and a sedentary lifestyle contribute to an increasing number of people developing fatty liver disease.

21 Feb 2023

The efficiency of lifestyle intervention, orlistat, and experimental diet therapy in patients with obesity and metabolic-associated fatty liver disease

Researchers compared the effects of an experimental low-carbohydrate and high-protein diet and orlistat with that of a control diet to examine their impact on Asian MAFLD patients with obesity.

14 Feb 2023

Protein activity found to be more dysregulated in the blood of patients with alcohol-associated hepatitis

Biochemist Jon Jacobs has analyzed the blood of patients with diseases and conditions such as Ebola, cancer, tuberculosis, hepatitis, diabetes, Lyme disease, brain injury and influenza.

9 Feb 2023

EGFR protein plays a decisive role in the penetration of hepatitis E virus into cells

A certain surface protein is crucial to allow the hepatitis E virus to enter cells. Medication can suppress it.