Molecular & Structural Biology

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Scientists reveal new insights into how red light-regulated histidine kinases function

Scientists have revealed new information on how red light-regulated histidine kinases function.

14 Jun 2024

HiDEF-seq technique reveals the origins of DNA mutations in single strands

Mutations are changes in the molecular "letters" that make up the DNA code, the blueprint for all living cells. Some of these changes can have little effect, but others can lead to diseases, including cancer.

12 Jun 2024

Researchers engineer water-soluble histidine kinase for enhanced antibiotic drug screens

A bacterial enzyme called histidine kinase is a promising target for new classes of antibiotics. However, it has been difficult to develop drugs that target this enzyme, because it is a "hydrophobic" protein that loses its structure once removed from its normal location in the cell membrane.

11 Jun 2024

Johns Hopkins researchers discover how epilepsy drug modulates brain activity

By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius -; nearly twice as cold as the coldest places in Antarctica -; scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.

10 Jun 2024

CSHL team identifies crucial protein interactions in RNA splicing process

Bodybuilders and cellular mechanisms agree generating protein is a heavy lift. To complete the task, cells rely on complexes called spliceosomes.

10 Jun 2024

Simple peptide modification could unlock a whole class of targets for drug discovery

A relatively simple peptide modification could unlock a whole class of targets for drug discovery, new research shows.

7 Jun 2024

Father's diet before conception can impact children's metabolic health, study finds

Research reveals that a father's high-fat diet can influence offspring's metabolic health through changes in sperm mitochondrial RNA, potentially leading to glucose intolerance.

7 Jun 2024

UCLA researchers discover key protein regulating blood stem cell self-renewal

UCLA scientists have identified a protein that plays a critical role in regulating human blood stem cell self-renewal by helping them sense and interpret signals from their environment.

5 Jun 2024

Salk researchers unveil SWI/SNF variants' role in macrophage immune responses

Bacteria, parasites, viruses-;the immune system tackles them all. At the front line of the human immune response are cells called macrophages, which are responsible for correctly identifying intruders and then directing how the entire immune system responds.

5 Jun 2024

Study reveals new insight into how human telomeres function at the molecular level

The length of telomeres that protect the ends of our chromosomes should be tightly regulated. Those that are too long predispose to cancer, and those that are too short lose their protective ability, resulting in telomere disorders with serious health consequences.

4 Jun 2024

New computational method developed for linking DNA marks to gene activity

Scientists at La Jolla Institute for Immunology (LJI) have developed a new computational method for linking molecular marks on our DNA to gene activity.

4 Jun 2024

Canagliflozin enhances senescent cell clearance, improving aging-related conditions

Whether sodium-glucose co-transporter 2 (SGLT2) inhibitors induce senolysis.

3 Jun 2024

Unveiling the epigenetic impact of prenatal amphetamine exposure using C. elegans models

Amphetamine is a psychostimulant that has been used to treat a variety of brain dysfunctions. However, it is a highly abused drug.

30 May 2024

Decoding the function of SRSF1 protein in RNA splicing and translation regulation

RNA transcription is the genomic process in which a cell produces a duplicate of a gene's DNA sequence.

30 May 2024

Advancing protein structure prediction with quantum computing

Researchers from Cleveland Clinic and IBM recently published findings in the Journal of Chemical Theory and Computation that could lay the groundwork for applying quantum computing methods to protein structure prediction.

30 May 2024

hnRNPM's protective role in protein synthesis precision uncovered

Researchers at Baylor College of Medicine and collaborating institutions have discovered that a protein called hnRNPM helps protect the integrity of the process cells use to make proteins.

30 May 2024

Exercise-induced exerkines: Secret weapon in disease prevention and therapy

A recent review in Signal Transduction and Targeted Therapy highlights the role of exercise-induced molecules, exerkines, in disease prevention and treatment, emphasizing their molecular mechanisms and therapeutic potential.

29 May 2024

Researchers decode spatial structure of prime editor

Joint research led by Yutaro Shuto, Ryoya Nakagawa, and Osamu Nureki of the University of Tokyo determined the spatial structure of various processes of a novel gene-editing tool called "prime editor."

29 May 2024

Scientists design new way to "cloak" proteins for targeted therapeutic delivery

Cornell University scientists have designed a way to "cloak" proteins in a generalized technique that could lead to repurposing things like antibodies for biological research and therapeutic applications.

28 May 2024

Underappreciated set of enzymes connected to the regulation of hippo pathway in cancer

Within the family of cell membrane lipids known as phosphoinositides and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have been cast in a starring role as scientists study their involvement in cancer, diabetes and many cellular activities.

28 May 2024

Molecular & Structural Biology

Scientists reveal new insights into how red light-regulated histidine kinases function

HiDEF-seq technique reveals the origins of DNA mutations in single strands

Researchers engineer water-soluble histidine kinase for enhanced antibiotic drug screens

Johns Hopkins researchers discover how epilepsy drug modulates brain activity

CSHL team identifies crucial protein interactions in RNA splicing process

Simple peptide modification could unlock a whole class of targets for drug discovery

Father's diet before conception can impact children's metabolic health, study finds

UCLA researchers discover key protein regulating blood stem cell self-renewal

Salk researchers unveil SWI/SNF variants' role in macrophage immune responses

Study reveals new insight into how human telomeres function at the molecular level

New computational method developed for linking DNA marks to gene activity

Canagliflozin enhances senescent cell clearance, improving aging-related conditions

Unveiling the epigenetic impact of prenatal amphetamine exposure using C. elegans models

Decoding the function of SRSF1 protein in RNA splicing and translation regulation

Advancing protein structure prediction with quantum computing

hnRNPM's protective role in protein synthesis precision uncovered

Exercise-induced exerkines: Secret weapon in disease prevention and therapy

Researchers decode spatial structure of prime editor

Scientists design new way to "cloak" proteins for targeted therapeutic delivery

Underappreciated set of enzymes connected to the regulation of hippo pathway in cancer

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