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Gut bacteria turn dietary phytate into health-boosting fatty acids, study shows

Study reveals that human gut bacteria, particularly Mitsuokella jalaludinii, efficiently degrade dietary phytate into short-chain fatty acids, enhancing health benefits through microbial synergy.

12 Jun 2024

UD researchers pioneer universal, economical method for proteomics sample preparation

Proteins are workhorses that carry out most of the biological functions in our cells. While the genes we inherit from our parents, our so-called genome, are fixed and usually remain unchanged throughout our lives, proteins in our bodies are constantly changing, as we age, under different health conditions and upon stimulation, such as with medical treatment.

11 Jun 2024

Transplanting healthy skin may be an effective strategy for treating rare skin diseases

Researchers from Nagoya University Graduate School of Medicine in Japan have successfully treated the skin diseases epidermolytic ichthyosis (EI) and ichthyosis with confetti (IWC) by transplanting genetically healthy skin to inflamed areas.

10 Jun 2024

Understanding Crohn's disease through 'mini-gut' models

Cambridge scientists have grown 'mini-guts' in the lab to help understand Crohn's disease, showing that 'switches' that modify DNA in gut cells play an important role in the disease and how it presents in patients.

10 Jun 2024

Genome sequencing identifies genetic disorders missed by exome analysis

Genetic mutations in human DNA can prevent proteins that perform important functions in the body from being formed correctly.

10 Jun 2024

CSHL team identifies crucial protein interactions in RNA splicing process

Bodybuilders and cellular mechanisms agree generating protein is a heavy lift. To complete the task, cells rely on complexes called spliceosomes.

10 Jun 2024

Efficient whole-gene insertions can be achieved with improved gene-editing technology

Scientists at the Broad Institute of MIT and Harvard have improved a gene-editing technology that is now capable of inserting or substituting entire genes in the genome in human cells efficiently enough to be potentially useful for therapeutic applications.

10 Jun 2024

Do taste genes influence how much alcohol we drink and our body fat?

Study examines how polymorphisms in bitter taste receptor genes relate to alcohol consumption and body fat percentage, revealing significant associations with TAS2R13 but not TAS2R38.

9 Jun 2024

Inherited gene sequences predict breast cancer type and severity, study reveals

A Stanford Medicine study of thousands of breast cancers has found that the gene sequences we inherit at conception are powerful predictors of the breast cancer type we might develop decades later and how deadly it might be.

7 Jun 2024

How increased mTOR activity shortens lifespan and promotes aging-related diseases

The reality of a population who is aging at an accelerated rate makes it a priority to understand what happens in the body over time, on a molecular scale.

7 Jun 2024

Key protein orco crucial for ant olfactory neuron survival and social behavior

While smell plays a considerable role in the social interactions of humans-;for instance, signaling fear or generating closeness-;for ants, it is vitally important.

7 Jun 2024

Gene therapy trial: restored hearing in children with hereditary deafness

The safety and effectiveness of binaural adeno-associated virus 1 (AAV1)-human otoferlin (hOTOF) therapy in five children with autosomal recessive deafness 9 (DFNB9).

7 Jun 2024

Father's diet before conception can impact children's metabolic health, study finds

Research reveals that a father's high-fat diet can influence offspring's metabolic health through changes in sperm mitochondrial RNA, potentially leading to glucose intolerance.

7 Jun 2024

Genetic discovery reveals key to inflammatory diseases

Researchers discovered that a specific haplotype on chromosome 21 is linked to five inflammatory diseases, offering insights into potential new treatments.

7 Jun 2024

New molecular portrait of KRAS in pancreatic cancer may guide better treatments

Researchers at UNC Lineberger Comprehensive Cancer Center and colleagues have established the most comprehensive molecular portrait of the workings of KRAS, a key cancer-causing gene or "oncogene," and how its activities impact pancreatic cancer outcomes.

6 Jun 2024