Cell Biology

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Stem cell breakthrough: EPHA2 protein may hold key to safer regenerative therapies

Pluripotent stem cells (PSCs) are a type of stem cells capable of developing into various cell types. Over the past few decades, scientists have been working towards the development of therapies using PSCs.

30 May 2024

Miniaturized CRISPR protein opens door for gene therapy with adeno-associated virus

Researchers have developed a novel version of a key CRISPR gene-editing protein that shows efficient editing activity and is small enough to be packaged within a non-pathogenic virus that can deliver it to target cells.

30 May 2024

Cervix-on-a-Chip: A breakthrough model for studying women's health

Bacterial Vaginosis (BV) has been identified as one of the many unmet needs in women's health and affects more than 25% of reproductive-aged women.

30 May 2024

Study reveals sex-specific cognitive effects of astrocytic receptors

Weill Cornell Medicine scientists have uncovered the first evidence that astrocyte receptors can trigger opposite effects on cognitive function in male and female preclinical models.

30 May 2024

How tight binding between immune cells dictates T cell cancer-fighting ability

Immunotherapy, treatments that reinvigorate immune cells' anti-cancer activity or reprogram T cells to target cancer, has shown promise in treating leukemias but has not yet been realized in solid tumors.

30 May 2024

Mast cells and PGE2: Key players in controlling asthma inflammation

Previous research indicates that mast cells, a type of immune cell found in the tissues throughout the body, cause inflammation during an asthma attack, inducing symptoms such as trouble breathing and narrowing of the airways.

30 May 2024

Newly discovered lincRNA controls the development and function of regulatory T cells

The T cells in our blood fight against cancer, viruses and bacteria. Specific regulatory T cells are required to control faulty immune responses, and disruption in their function may lead to autoimmune diseases or cancer.

30 May 2024

hnRNPM's protective role in protein synthesis precision uncovered

Researchers at Baylor College of Medicine and collaborating institutions have discovered that a protein called hnRNPM helps protect the integrity of the process cells use to make proteins.

30 May 2024

Researchers develop novel method to 'grow your own' donor skin

Skin grafting is an essential procedure used to treat severe skin wounds. In the case of extensive wounds, however, it can be challenging to harvest enough donor skin, and generating artificial skin substitutes that include hair follicles and sweat glands and can engraft on deep wounds has not been successful.

29 May 2024

New AI model Dev-ResNet accurately monitors embryonic development in real-time

Research led by the University of Plymouth has shown that a new deep learning AI model can identify what happens and when during embryonic development, from video.

28 May 2024

Scientists design new way to "cloak" proteins for targeted therapeutic delivery

Cornell University scientists have designed a way to "cloak" proteins in a generalized technique that could lead to repurposing things like antibodies for biological research and therapeutic applications.

28 May 2024

MUSC researchers unravel the mystery of cancer recurrence

MUSC Hollings Cancer Center researchers have unlocked a discovery that could help to explain why cancer can recur in patients who have undergone chemotherapy or radiotherapy.

28 May 2024

Understanding genetic mosaicism in human cells

In a study led by Jan Korbel at the European Molecular Biology Laboratory (EMBL) and Ashley Sanders at the Berlin Institute for Medical Systems Biology of the Max Delbrück Center (MDC-BIMSB), researchers have found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations – copy number variations and chromosomal rearrangements, for example – without causing any apparent disease or abnormality.

28 May 2024

Researchers discover how protein XPD detects and repairs DNA damage

Researchers at the University of Würzburg, led by Caroline Kisker in cooperation with Claudia Höbartner, discovered how the protein XPD detects a severe DNA damage and controls its repair.

28 May 2024

Soft X-ray microscope captures living mammalian cells

Researchers have developed a new technique to view living mammalian cells.

24 May 2024

Investigating the evolution of cell division mechanisms in Ichthyosporea

Cell division is fundamental to life, enabling growth, reproduction, and survival across all organisms, from single-celled bacteria to complex multicellular animals.

23 May 2024

Study explores how different modes of cell division evolved in close relatives of fungi and animals

Cell division is one of the most fundamental processes of life. From bacteria to blue whales, every living being on Earth relies on cell division for growth, reproduction, and species survival.

23 May 2024

Unraveling the role of MIR1 gene in Candida albicans virulence

This study is led by Professor Yan Wang (School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai, China). Her team found that the lack of MIR1 gene, which encodes mitochondrial phosphate carrier, can lead to severe virulence defects in Candida albicans.

22 May 2024

Study reveals biological repercussions of UV-C radiation exposure from germicidal lamps

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 9, entitled, "Germicidal lamps using UV-C radiation may pose health safety issues: a biomolecular analysis of their effects on apoptosis and senescence."

22 May 2024

Single-cell analysis reveals insights into immune responses during xenotransplantation

Surgical teams at NYU Langone Health performed the world's first genetically modified pig kidney transplants into a human body in September and November 2021, and then transplanted two pig hearts in the summer of 2022.

22 May 2024