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Single infusion of engineered T-cells achieves lasting asthma remission in mice

Researchers demostrate that durable asthma remission can be achieved with engineered and long-lived CAR T-cell treatment in mice.

31 May 2024

Female and male heart failure may require distinct treatments

A new study from the UC Davis School of Medicine found striking differences at the cellular level between male and female mice with heart failure with preserved ejection fraction (HFpEF).

30 May 2024

Memory decline reported by patients and partners may signal early Alzheimer's changes

A new study adds further evidence that when a patient or family member notices signs of persistent memory loss, it's important to speak with a doctor.

30 May 2024

Advancing therapeutic insights: The impact of understanding cellular target engagement with NanoBRET® technology

In this Interview, NewsMedical speaks with Amy Landreman about NanoBRET® Technology and its role in cellular target engagement.

From Promega Corporation 30 May 2024

Exercise-induced exerkines: Secret weapon in disease prevention and therapy

A recent review in Signal Transduction and Targeted Therapy highlights the role of exercise-induced molecules, exerkines, in disease prevention and treatment, emphasizing their molecular mechanisms and therapeutic potential.

29 May 2024

New antibody shows promise as universal weapon against COVID-19 variants

SARS-CoV-2, the virus that causes COVID-19 disease, continues to evolve and evade current vaccine and therapeutic interventions.

29 May 2024

New type of immunotherapy shows promising preclinical results against osteosarcoma

A new type of immunotherapy, developed by UCL researchers, has shown promising preclinical results against a bone cancer called osteosarcoma, as part of a study in mice.

29 May 2024

New Alzheimer's drug LM11A-31 shows promise in slowing disease progression in clinical trial

A recent study in Nature Medicine found that LM11A-31, targeting the p75 neurotrophin receptor, is safe and shows promise in slowing Alzheimer's disease progression. The trial indicated significant biomarker improvements and potential benefits for further clinical investigation.

28 May 2024

Underappreciated set of enzymes connected to the regulation of hippo pathway in cancer

Within the family of cell membrane lipids known as phosphoinositides and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have been cast in a starring role as scientists study their involvement in cancer, diabetes and many cellular activities.

28 May 2024

New paper reveals the broad potential of TNIK as a therapeutic target for some aging-related diseases

A new paper in Trends in Pharmacological Sciences from researchers at generative artificial intelligence (AI)- and robotics-powered clinical stage drug discovery company Insilico Medicine ("Insilico") and ETH Zurich reveals the broad potential of TNIK as a therapeutic target for some of the most pervasive aging-related diseases, including fibrosis, cancer, obesity, and Alzheimer's.

28 May 2024

Changing the landscape of R&D to build clinical success from the ground up

In this interview, NewsMedical talks to Amanda Jones at Revvity about the strategies and solutions available to revolutionize the landscape of R&D in clinical research.

From Revvity 28 May 2024

Researchers identify novel way to potentially slow down or halt Alzheimer’s progression

Researchers at the Icahn School of Medicine at Mount Sinai have made a significant breakthrough in Alzheimer's disease research by identifying a novel way to potentially slow down or even halt disease progression.

27 May 2024

In-vivo imaging to quantify collagen morphology in preclinical melanoma models during immunotherapy

Collagen, a major component of the extracellular matrix, plays a crucial role in tumor development.

23 May 2024

Tailoring polymeric micelles for improved olaparib solubility and drug release

Olaparib is a selective poly (ADP-ribose) polymerase inhibitor. However, its clinical application is hindered by low solubility and undesired pharmacokinetic profiles (e.g., relatively short circulation).

23 May 2024

Study offers insights into factors influencing older adults to stop driving

What factors lead older adults to stop driving? A new study followed older adults who had no memory or thinking problems to examine this question.

23 May 2024

Insilico Medicine's leadership to address key challenges in AI drug discovery at BIO Convention

Leadership from clinical stage artificial intelligence (AI)-powered drug discovery company Insilico Medicine ("Insilico") will attend the BIO International Convention in San Diego June 3-6 and present on key issues facing AI drug discovery.

23 May 2024

Evaluating the performance of 3D power Doppler in differential diagnosis of adnexal masses

Three-dimensional power Doppler (3DPD) ultrasound has been used for assessing adnexal masses, and in this study, we aimed to perform a meta-analysis to evaluate its role in the differential diagnosis of adnexal masses.

23 May 2024

Cognitive decline predicts driving cessation in seniors

One of the thorniest decisions facing older adults is when to give up their keys and stop driving. A new study by researchers at Washington University School of Medicine in St. Louis could provide guidance in helping seniors plan ahead.

22 May 2024

Study reveals endurance exercise's impact on the biological molecules of animals and humans

As part of an ongoing national research effort to better understand how physical activity improves health and prevents disease, seven University of Colorado Department of Medicine faculty members contributed to an article recently published in Nature, an international journal of science.

22 May 2024

Improved animal model captures full picture of periodontal disease progression

Periodontal disease, represented by periodontitis, is the leading cause of tooth loss and affects close to one in five adults worldwide.

22 May 2024

Preclinical News and Research

Single infusion of engineered T-cells achieves lasting asthma remission in mice

Female and male heart failure may require distinct treatments

Memory decline reported by patients and partners may signal early Alzheimer's changes

Advancing therapeutic insights: The impact of understanding cellular target engagement with NanoBRET® technology

Exercise-induced exerkines: Secret weapon in disease prevention and therapy

New antibody shows promise as universal weapon against COVID-19 variants

New type of immunotherapy shows promising preclinical results against osteosarcoma

New Alzheimer's drug LM11A-31 shows promise in slowing disease progression in clinical trial

Underappreciated set of enzymes connected to the regulation of hippo pathway in cancer

New paper reveals the broad potential of TNIK as a therapeutic target for some aging-related diseases

Changing the landscape of R&D to build clinical success from the ground up

Researchers identify novel way to potentially slow down or halt Alzheimer’s progression

In-vivo imaging to quantify collagen morphology in preclinical melanoma models during immunotherapy

Tailoring polymeric micelles for improved olaparib solubility and drug release

Study offers insights into factors influencing older adults to stop driving

Insilico Medicine's leadership to address key challenges in AI drug discovery at BIO Convention

Evaluating the performance of 3D power Doppler in differential diagnosis of adnexal masses

Cognitive decline predicts driving cessation in seniors

Study reveals endurance exercise's impact on the biological molecules of animals and humans

Improved animal model captures full picture of periodontal disease progression

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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