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New insights into blood precursors of pathogenic macrophages in RA

The exact origin and precursor differentiation route of tissue macrophages remains controversial. At the 2024 congress of EULAR - The European Alliance of Associations for Rheumatology - new work sheds light on blood precursors of pathogenic tissue macrophages.

13 Jun 2024

Integration of genomics, epigenomics, and transcriptomics in understanding Alzheimer's pathogenesis

With the advent of new omics technologies in recent years, there has been a deluge of complex, high-dimensional data on Alzheimer's disease (AD).

12 Jun 2024

Father's diet before conception can impact children's metabolic health, study finds

Research reveals that a father's high-fat diet can influence offspring's metabolic health through changes in sperm mitochondrial RNA, potentially leading to glucose intolerance.

7 Jun 2024

New computational method analyzes complex tissue data to transform treatment of disease

Researchers at the University of Michigan and Brown University have developed a new computational method to analyze complex tissue data that could transform our current understanding of diseases and how we treat them.

6 Jun 2024

Ohio State creates user-friendly repository to help study Alzheimer's disease

A searchable database is now ready to help study Alzheimer's disease.

6 Jun 2024

STew: A new method for unveiling the spatial fingerprint of diseases

In disease research, it's important to know gene expression and where in a tissue the expression is happening, but marrying the two sets of information can be challenging.

4 Jun 2024

Single-cell analysis reveals insights into immune responses during xenotransplantation

Surgical teams at NYU Langone Health performed the world's first genetically modified pig kidney transplants into a human body in September and November 2021, and then transplanted two pig hearts in the summer of 2022.

22 May 2024

Treating obesity using glucagon-like peptide-1-directed N-methyl-D-aspartate receptor inhibition

Bimodal drug that successfully cures obesity, hyperglycemia, and dyslipidemia in mouse models.

20 May 2024

FAU researchers receive grants to tackle Alzheimer's disease

Three Florida Atlantic University researchers at the forefront of Alzheimer's disease (AD) research have each received a $350,000 grant from the Florida Department of Health's "Ed and Ethel Moore Alzheimer's Disease Research Program."

8 May 2024

Researchers map early genetic development of the brain

In an article published in Nature, researchers from Karolinska Institutet present an atlas of the early development of the brain.

3 May 2024

Researchers identify key molecular alterations from endurance exercise that could combat chronic diseases

A whole-organism molecular map of the temporal effects of endurance training in rats.

3 May 2024

Study uncovers molecular mechanism linking nonsense-mediated RNA decay to microcephaly

Nonsense-mediated RNA decay, or NMD, is an evolutionarily conserved molecular mechanism in which potentially defective messenger RNAs, or mRNAs (genetic material that instructs the body on how to make proteins), are degraded.

1 May 2024

New study reveals potential cellular mechanism behind cognitive decline in Alzheimer's

Researchers have developed a robust method for identifying rare brain neurons that re-enter the cell cycle, offering insights into their role in cognitive disorders such as Alzheimer's disease.

28 Apr 2024

Multi-omics approach powers Karolinska Institutet's Single Cell Atlas

Researchers at Karolinska Institutet have developed a web-based platform that offers an unprecedented view of the human body at the cellular level.

25 Apr 2024

Study unveils novel bladder cancer diagnostic model based on key mitochondrial genes

A novel diagnostic model using machine learning (ML).

24 Apr 2024

Spatiotemporal transcriptomics reveals insights into primate ovarian aging

The ovary is an essential organ for female fertility, and its age-dependent decline in function is a major cause of infertility.

18 Apr 2024

First-of-its-kind AI tool predicts patient response to cancer drugs at single-cell resolution

With more than 200 types of cancer and every cancer individually unique, ongoing efforts to develop precision oncology treatments remain daunting.

18 Apr 2024

Machine learning reveals age-related decline in stemness across human tissues

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 7, entitled, "Evidence of a pan-tissue decline in stemness during human aging."

16 Apr 2024

Study reveals molecular changes in brain cells with Lewy bodies

A new study from Van Andel Institute scientists offers a first look into the complex molecular changes that occur in brain cells with Lewy bodies, which are key pathological hallmarks of Parkinson's disease and some dementias.