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Dose reduction of glucocorticoids in systemic lupus erythematosus

Glucocorticoids are a mainstay of treatment for systemic lupus erythematosus (SLE). But due to long-term adverse effects, dose reduction is becoming a crucial part of treat-to-target management goals.

13 Jun 2024

New insights into blood precursors of pathogenic macrophages in RA

The exact origin and precursor differentiation route of tissue macrophages remains controversial. At the 2024 congress of EULAR - The European Alliance of Associations for Rheumatology - new work sheds light on blood precursors of pathogenic tissue macrophages.

13 Jun 2024

Study demonstrates efficacy of treat-to-target in early axial spondyloarthritis

Early therapeutic interventions in inflammatory rheumatic diseases have proven successful in inducing drug-free remission, and EULAR - The European Alliance of Associations for Rheumatology - recommends early intervention in arthritis, since conventional synthetic disease-modifying antirheumatic drugs (csDMARD) have been shown to slow disease progression in both rheumatoid and psoriatic arthritis.

13 Jun 2024

Enhancing CAR-T cell therapy with biodegradable scaffolds

CAR-T cell therapies are transforming the treatment of previously incurable blood cancers. Six approved CAR-T products have been administered to more than 20,000 people, and more than 500 clinical trials are underway.

12 Jun 2024

Newcells Biotech strengthens executive and US team with key appointments

Dr Valeria Chichagova appointed as Director of Technology, Dr Colin Brown as Chief Scientific Officer, and Professor Lyle Armstrong as Scientific Advisor.

From Newcells Biotech 11 Jun 2024

Microneedle patch holds promise for promoting hair regrowth caused by alopecia areata

Alopecia areata (AA) is an autoimmune disease characterized by hair loss, which occurs when T cells of the immune system mistakenly attack hair follicles.

8 Jun 2024

EULAR develops new classification criteria for hand osteoarthritis

At present, classifying hand osteoarthritis (OA) is based on clinical findings, and available tools are not able to distinguish between certain phenotypes.

7 Jun 2024

Innovative microneedle patch shows promise in treating alopecia areata

Alopecia areata (AA) is an autoimmune disease characterized by hair loss, which occurs when T cells of the immune system mistakenly attack hair follicles.

6 Jun 2024

Wearable brain scanner tracks developmental milestones in young children

New research has given the clearest ever picture of young children's developing brains, using a wearable brain scanner to map electrical brain activity.

4 Jun 2024

Mouse study identifies sex differences at the cellular level for heart failure

Researchers investigated the impact of aldosterone infection in db/db mice on HFpEF, focusing on sex differences and alterations in intracellular calcium handling and cardiomyocyte electrophysiology.

4 Jun 2024

SCIEX launches new data independent acquisition, ZT Scan DIA, at ASMS 2024

At ASMS 2024, SCIEX, a global leader in life science analytical technologies, introduces ZT Scan DIA for LC-MS/MS, the next generation in data-independent acquisition (DIA) that leverages the combination of the quadrupole dimension with the rich MS2 data attainable from the Zeno trap.

From SCIEX 4 Jun 2024

New vessel-chip deployment platform holds promise for personalized drug testing

The pharmaceutical drug development and approval process is a multi-step undertaking that requires a plethora of testing before reaching the market.

31 May 2024

Eye-tracking technology offers earlier, more accurate autism diagnosis

Nearly 3% of all children in the United States are diagnosed with autism, according to the Centers for Disease Control and Prevention.

31 May 2024

Synthetic cartilage plugs may help heal osteochondral defects and avoid total knee replacements

Osteochondral defects (OCDs) can cause damage to cartilage and underlying bone, leading to chronic pain and loss of joint function.

31 May 2024

UQ receives $5 million from Medical Research Future Fund to improve treatment for post-stroke aphasia

The Queensland Aphasia Research Centre at The University of Queensland has been awarded almost $5 million from the Medical Research Future Fund to improve treatment for the growing number of Australians living with post-stroke aphasia.

30 May 2024

Cervix-on-a-Chip: A breakthrough model for studying women's health

Bacterial Vaginosis (BV) has been identified as one of the many unmet needs in women's health and affects more than 25% of reproductive-aged women.

30 May 2024

Engineered immunogens show promise in inducing HIV broadly neutralizing antibodies

Using a combination of cutting-edge immunologic technologies, researchers have successfully stimulated animals' immune systems to induce rare precursor B cells of a class of HIV broadly neutralizing antibodies (bNAbs).

30 May 2024

Decoding the function of SRSF1 protein in RNA splicing and translation regulation

RNA transcription is the genomic process in which a cell produces a duplicate of a gene's DNA sequence.

30 May 2024

Driving innovation in regenerative medicine: €37.5 million grant for DRIVE-RM consortium

The DRIVE-RM consortium, led by Professor of Experimental Nephrology Marianne Verhaar from UMC Utrecht, has been awarded €37.5 million under the prestigious NWO SUMMIT program.

24 May 2024

Tailoring polymeric micelles for improved olaparib solubility and drug release

Olaparib is a selective poly (ADP-ribose) polymerase inhibitor. However, its clinical application is hindered by low solubility and undesired pharmacokinetic profiles (e.g., relatively short circulation).

23 May 2024