Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Boosting mitochondrial health can reverse protein clumping in aging and Alzheimer's

It has long been known that a hallmark of Alzheimer's disease, and most other neurodegenerative diseases, is the clumping together of insoluble protein aggregates in the brain.

16 May 2024

New therapy shows greater weight loss in mice by targeting brain's appetite center

A groundbreaking paper in Nature describes a promising new therapy for obesity that leads to greater weight loss in mice than existing medications.

16 May 2024

Repurposing human-approved drugs for prion disease treatment

Prions are the abnormal, pathogenic agents that are transmissible and are able to induce abnormal folding of specific normal cellular proteins.

16 May 2024

Unraveling the mystery of Alzheimer's resilience at molecular level

Everyone experiences aging in their own way, and factors such as genetics, lifestyle and environment play a role in this process.

16 May 2024

Study identifies a new biomarker for Alzheimer's disease in asymptomatic stages

A recent study led by the Molecular and Cellular Neurobiotechnology group at the Institute for Bioengineering of Catalonia (IBEC) and the University of Barcelona has identified a new biomarker for Alzheimer's disease in asymptomatic stages of the disease.

15 May 2024

Study reveals CNTN4 gene's role in neuronal development and Alzheimer's disease pathogenesis

New research has shed light on the complex interplay between cell proteins, and how they impact on neurons in neurodevelopmental disorders and Alzheimer's disease.

15 May 2024

Sleep and anesthesia hinder brain toxin clearance, study reveals

Researchers found that brain clearance is reduced during both sleep and anesthesia, contradicting the belief that these states enhance toxin removal.

14 May 2024

New technique reveals brain cells age at different rates

Engineers at the University of California San Diego have discovered that some brain cells age more rapidly than others, and they are disproportionately abundant in individuals afflicted with Alzheimer's disease.

14 May 2024

Racial and ethnic disparities in Alzheimer's diagnosis and CNS drug prescription

Compared to Black and Asian people, white and Hispanic people with Alzheimer's disease and related dementias were most likely to be diagnosed with symptoms like depression and agitation, according to a new study from the USC Schaeffer Center for Health Policy & Economics.

14 May 2024

Study sheds light on the crucial role of glutamate tRNA fragments in brain aging and Alzheimer's disease

A significant research paper published in the journal Cell Metabolism by the team of Prof. LIU Qiang at the University of Science and Technology of China reveals the critical role of glutamate tRNA fragments in brain aging and Alzheimer's disease.

14 May 2024

Study examines association between neighborhood disadvantage and DNA methylation in brain tissue

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, "The association between neighborhood deprivation and DNA methylation in an autopsy cohort."

9 May 2024

Ensemble deep learning models enhance early diagnosis of Alzheimer's disease using neuroimaging data

The developments in ensemble deep learning (EDL) models used to characterize and estimate AD.

9 May 2024

Superagers' brains resist age-related decline, study finds

Researchers explored brain white matter integrity in superagers, older adults with exceptional cognitive abilities, finding that while overall white matter health showed no significant differences, superagers displayed superior microstructure in frontal regions, potentially explaining their resistance to cognitive decline.

8 May 2024

Youth-onset diabetes linked to higher Alzheimer's risk

Young people with diabetes may have a significantly higher risk of developing Alzheimer's disease later in life, according to a new study by researchers in the Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center at the University of Colorado Anschutz Medical Campus.

8 May 2024

FAU researchers receive grants to tackle Alzheimer's disease

Three Florida Atlantic University researchers at the forefront of Alzheimer's disease (AD) research have each received a $350,000 grant from the Florida Department of Health's "Ed and Ethel Moore Alzheimer's Disease Research Program."

8 May 2024

Mathematical microscope sheds light on efficient memory formation even during sleep

UCLA Health researchers have discovered a mechanism that creates memories while reducing metabolic cost, even during sleep.

8 May 2024

APOE4 gene linked to early onset Alzheimer's, target for therapeutic intervention

A study published in Nature Medicine delineates how APOE4 homozygosity distinctly accelerates Alzheimer's disease pathology and biomarkers from the age of 55, suggesting a unique form of the disease and a potential focus for targeted therapies.

8 May 2024

Study identifies APOE4 homozygotes as high-risk group for Alzheimer's disease

Researchers from the Research Area on Neurological Diseases, Neuroscience, and Mental Health at the Sant Pau Research Institute, led by Dr. Juan Fortea, Director of the Memory Unit of the Neurology Service at the same hospital, have found that over 95% of individuals over 65 years old who have two copies of the APOE4 gene -APOE4 homozygotes- show biological characteristics of Alzheimer's pathology in the brain or biomarkers of this disease in cerebrospinal fluid and PET scans.

6 May 2024

Global research offers insights about health burden disparities between genders

Globally, there are substantial differences between females and males (aged 10 and older) when it comes to health, with limited progress in bridging these health gaps over the past 30 years, according to a new study examining the disparities in the 20 leading causes of disease burden between females and males, across ages and regions, published in The Lancet Public Health journal.

2 May 2024

Rapamycin shows promise in slowing Alzheimer's disease progression linked to seizures

Protein imbalances that increase brain cell excitability may explain why individuals with Alzheimer's disease (AD) who also experience seizures demonstrate more rapid cognitive decline than those who do not experience seizures.

2 May 2024

Alzheimer's Disease News and Research

Further Reading

Boosting mitochondrial health can reverse protein clumping in aging and Alzheimer's

New therapy shows greater weight loss in mice by targeting brain's appetite center

Repurposing human-approved drugs for prion disease treatment

Unraveling the mystery of Alzheimer's resilience at molecular level

Study identifies a new biomarker for Alzheimer's disease in asymptomatic stages

Study reveals CNTN4 gene's role in neuronal development and Alzheimer's disease pathogenesis

Sleep and anesthesia hinder brain toxin clearance, study reveals

New technique reveals brain cells age at different rates

Racial and ethnic disparities in Alzheimer's diagnosis and CNS drug prescription

Study sheds light on the crucial role of glutamate tRNA fragments in brain aging and Alzheimer's disease

Study examines association between neighborhood disadvantage and DNA methylation in brain tissue

Ensemble deep learning models enhance early diagnosis of Alzheimer's disease using neuroimaging data

Superagers' brains resist age-related decline, study finds

Youth-onset diabetes linked to higher Alzheimer's risk

FAU researchers receive grants to tackle Alzheimer's disease

Mathematical microscope sheds light on efficient memory formation even during sleep

APOE4 gene linked to early onset Alzheimer's, target for therapeutic intervention

Study identifies APOE4 homozygotes as high-risk group for Alzheimer's disease

Global research offers insights about health burden disparities between genders

Rapamycin shows promise in slowing Alzheimer's disease progression linked to seizures

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