ACE Inhibitors News and Research

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ACE inhibitors act to reduce hypertension by interfering with the conversion of angiotensin I to artery-constricting angiotensin II. Blocking the production of angiotensin II results in arterial vasodilation and an accompanying reduction in blood pressure. ACE inhibitors currently are recommended as first-line therapy for hypertension in certain patient populations, because of their safety and efficacy.

Gene variations associated with effectiveness of blood pressure medications

Patients with hypertension and certain gene variations experienced varying results with some blood pressure medications, suggesting matching a patient's genotype with certain hypertension medications could result in more favorable outcomes, according to a study in the January 23 issue of JAMA: The Journal of the American Medical Association.

23 Jan 2008

Study proves the co-pay connection in chronic disease

As 2008 begins, millions of Americans are having to dig deeper into their own pockets every time they refill a prescription or see a doctor.

9 Jan 2008

Experimental IT to reduce medication errors under study

Medication errors are one of the most serious problems occurring in doctor's offices and out-patient clinics, and older persons with chronic conditions are the most vulnerable.

4 Jan 2008

Telmisartan potent against stroke

Telmisartan, a drug widely used to help control blood pressure, may have uniquely potent activity in preventing stroke, according to a new study conducted in an animal model.

13 Dec 2007

Simple two-in-one test signals high risk after a heart attack

Everyone loves a two-fer, but a two-in-one heart test that has the potential to save lives is the real deal.

4 Dec 2007

Captopril may limit radiation kidney damage in bone marrow transplant patients

Researchers at the Medical College of Wisconsin in Milwaukee have found that the risk of radiation injury in normal tissue after exposure may be reduced by a drug in common use. Their study in press appears in the on line issue of the International Journal of Radiation Oncology, Biology and Physics.

15 Nov 2007

UK hospitals short changing women with heart failure

Women with heart failure are less likely than men to receive recommended investigations and treatment, when admitted to hospital as an emergency, reveals an extensive UK survey, published ahead of print in the journal Heart.

14 Nov 2007

Novel approaches to hypertension control

A hypertension vaccine could be an important alternative to conventional drug therapy because of patients' inconsistent drug intake - if further research supports results from a small study testing the safety and tolerability of a vaccine.

6 Nov 2007

Women with implantable cardioverter defibrillators fare less well than men

While ICDs—implantable cardioverter defibrillators—are the device of choice to manage abnormal heart rhythms, a new study led by cardiologists at the University of Pennsylvania School of Medicine suggests that women with ICDs fare less well than their male counterparts.

6 Nov 2007

More effective method of treating high blood pressure

Scientists at Robarts Research Institute have developed a simplified and more effective method of treating high blood pressure.

6 Nov 2007

Half of heart attack patients stop taking lifesaving medications within three years

Recovery from heart attacks is best served by continuing to take prescribed medications.

6 Nov 2007

Hypertension drugs may prevent Alzheimer's Disease

New research is suggesting that some of the drugs commonly used to treat hypertension (high blood pressure) may offer another benefit.

28 Oct 2007

Heart drug perindopril helps seniors get active

According to scientists from Dundee University in Scotland, when seniors were given a drug commonly prescribed for heart conditions they were able to do more exercise.

10 Oct 2007

Perindopril for improving physical function in elderly people

A decline in physical function with age is strongly associated with disability in later life.

9 Oct 2007

ACE inhibitor perindopril may help improve cardiac complications from Marfan syndrome

Preliminary research suggests that use of the ACE inhibitor perindopril, along with a beta-blocker, may help reduce cardiac measures such as aortic stiffness and dilation that are associated with the cardiac complications of Marfan syndrome, according to an article in the October 3 issue of JAMA.

3 Oct 2007

Some GPs over-estimate adverse risks associated with the use of beta blocker drugs for heart disease

Some General Practitioners (GPs) over-estimate adverse risks associated with the use of beta blocker drugs in the fight against heart disease, according to research launched today at the British Pharmaceutical Conference (BPC) in Manchester.

11 Sep 2007

Lower blood pressure to manage type 2 diabetes

A small reduction in blood pressure produced a significant benefit in the largest study ever done on the treatment of patients with type 2 diabetes, presented on Sunday in Vienna at the European Society of Cardiology Congress, and published online in the Lancet the same day.

5 Sep 2007

Blood pressure drugs cut death rate in diabetes

The largest-ever study of treatments for diabetes has shown that a fixed combination of two blood pressure lowering drugs reduces the risk of death, as well as the risks of heart and kidney disease. Results from the ADVANCE (Action in Diabetes and Vascular Disease) Study were presented today at the European Society of Cardiology Congress 2007 in Vienna.

2 Sep 2007

Longer term effects of dementia drugs to be investigated

A £50,000 grant from the Alzheimer's Research Trust will look at whether ACE inhibitors used to treat Alzheimer's could have a longer term effect.

15 Aug 2007

Hypertension in the very elderly trial stopped

An international trial looking at the benefits of giving blood-pressure lowering medication to elderly patients has stopped early, after researchers observed significant reductions in overall mortality in those receiving treatment.

7 Aug 2007