ACE Inhibitors News and Research

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ACE inhibitors act to reduce hypertension by interfering with the conversion of angiotensin I to artery-constricting angiotensin II. Blocking the production of angiotensin II results in arterial vasodilation and an accompanying reduction in blood pressure. ACE inhibitors currently are recommended as first-line therapy for hypertension in certain patient populations, because of their safety and efficacy.

Coronary artery disease patients consistently fail to take life saving drugs

Nearly half the coronary artery disease (CAD) patients in a seven-year study admitted they don’t consistently take beta blockers, cholesterol-lowering drugs and other medications that could extend their lives, researchers report in Circulation: Journal of the American Heart Association.

10 Jan 2006

Quality of care for acute myocardial infarction in elderly patients with alcohol-related diagnoses

Older Americans with alcohol problems do not get worse treatment than their sober peers when they are hospitalized for a heart attack, according to new research on Medicare patients across the country.

6 Jan 2006

Implantable defibrillators benefit women as much as men after heart attack

Women who have had a heart attack get as much survival benefit as men from implanted cardioverter defibrillators (ICDs), devices designed to monitor the heart's pumping rhythm and shock it back to normal when needed, according to a study published in the December edition of the Journal of Cardiovascular Electrophysiology.

22 Dec 2005

Physicians slow to prescribe newer heart drugs

An analysis of the treatment received by more than 100,000 heart patients has shown that physicians' prescription practices for drugs proven effective for treating heart disease has shown steady improvement over the past three years, cardiologists at the Duke Clinical Research Institute (DCRI) have concluded.

7 Dec 2005

Aldosterone shows promise as stroke treatment

A bi-polar hormone that can contribute to strokes and minimize their damage is emerging as a therapeutic target in the battle against these brain attacks, researchers say.

5 Dec 2005

"Get With The Guidelines" programs improve care

After one year - Get With The GuidelinesSM programs used in hospitals significantly improved care for almost 30,000 coronary artery disease patients of all ages and sexes, according to research reported at the American Heart Association's Scientific Sessions 2005.

26 Nov 2005

Lack of aggressive treatment for clogged leg blood vessels means missed heart attack prevention opportunity

Despite the fact that clogged arteries in the legs usually mean clogged arteries near the heart, doctors often fail to give heart-protecting drugs to people with severe leg blood vessel blockages, a new University of Michigan-led study finds.

15 Nov 2005

Blood pressure near the heart is more predictive of cardiovascular outcomes than blood pressure measured in the arm

Results from a new study show that amlodipine-based (calcium channel blocker) treatment is much more effective at reducing blood pressure near the heart than a conventional atenolol-based (beta blocker) regimen.

14 Nov 2005

Early diagnosis and treatment of heart disease may lead to longer life in Duchenne and Becker muscular dystrophy patients

Cardiac disease, particularly dilated cardiomyopathy and heart failure, is the major cause of mortality in patients with muscular dystrophy and is present in most boys with Duchenne muscular dystrophy and approximately 70 percent of those with Becker muscular dystrophy. These are the two common forms of muscular dystrophy caused by defects in a gene called dystrophin.

30 Oct 2005

More doubt cast on benefit of beta blockers for high blood pressure

A comprehensive study has produced more evidence that a drug widely used to treat high blood pressure may not be the best option for many patients.

18 Oct 2005

Rates for new cases of kidney failure have stabilized

After 20 years of annual increases from 5 to 10 percent, rates for new cases of kidney failure have stabilized, according to new research from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). At the same time, dramatic racial disparities persist.

11 Oct 2005

Actos reduces the combined risk of non-fatal heart attacks, strokes in patients with type-2 diabetes

A study published in The Lancet shows that Takeda's Actos (pioglitazone HCl), an oral glucose lowering medication, significantly reduces the combined risk of non-fatal heart attacks, strokes and deaths by an additional 16% on top of standard medication

10 Oct 2005

Quality-improvement improves mortality in hospital

Heart attack death rates dropped significantly at hospitals that participated in a quality-improvement process that increased the use of evidence-based therapies, according to a new study in the Oct. 4, 2005, issue of the Journal of the American College of Cardiology.

28 Sep 2005

Researchers map genetic location that explains why certain blood pressure-lowering drugs aren't effective for some people

"The findings bring us a step closer to developing targeted therapies for patients with high blood pressure who might otherwise be started on medications that won't help," said lead author Sandosh Padmanabhan, Ph.D.

26 Sep 2005

Important new lessons learned from aspirin

No other medicine is as common, inexpensive, and yet powerful in so many ways as aspirin; yet despite a century of experience with the drug, researchers are still learning important new lessons, while raising new questions, according to seven special articles in the Sept. 20, 2005, issue of the Journal of the American College of Cardiology.

20 Sep 2005

Strokes and heart attacks can be prevented in people with high blood pressure

Most strokes and heart attacks in people with high blood pressure can be abolished by simply combining effective, modern blood pressure lowering drugs with treatment to reduce cholesterol.

6 Sep 2005

Benefits of starting CHF treatment with beta-blocker, bisoprolol

Initiating treatment with the selective beta-blocker, bisoprolol, is as effective and well tolerated as beginning treatment with an ACE inhibitor. However, starting treatment with bisoprolol may reduce the risk of death especially in the first year of treatment.

5 Sep 2005

Nurse-led multidisciplinary programme can help coronary patients and their families to reduce their risk of major cardiovascular disease

Early results from the EuroAction hospital project, announced today at the European Society of Cardiology, demonstrate how a nurse-led multidisciplinary programme, organised in busy general hospitals, can help coronary patients and their families to reduce their risk of major cardiovascular disease (CVD).

5 Sep 2005

Chronic heart failure (CHF) is common, deadly, disabling, costly but fortunately - treatable

During the last ten to 15 years, treatment of CHF has been dramatically improved by pharmacological therapy and devices. Treatment also has become more complicated.

5 Sep 2005

International SHAPE project reveals massive public lack of awareness on heart failure

An international survey of the public's awareness of heart failure has revealed a woeful and worrying level of ignorance, according to the lead author of the research, which is published (Wednesday 31 August) in Europe's leading cardiology journal European Heart Journal.

31 Aug 2005

ACE Inhibitors News and Research

Further Reading

Coronary artery disease patients consistently fail to take life saving drugs

Quality of care for acute myocardial infarction in elderly patients with alcohol-related diagnoses

Implantable defibrillators benefit women as much as men after heart attack

Physicians slow to prescribe newer heart drugs

Aldosterone shows promise as stroke treatment

"Get With The Guidelines" programs improve care

Lack of aggressive treatment for clogged leg blood vessels means missed heart attack prevention opportunity

Blood pressure near the heart is more predictive of cardiovascular outcomes than blood pressure measured in the arm

Early diagnosis and treatment of heart disease may lead to longer life in Duchenne and Becker muscular dystrophy patients

More doubt cast on benefit of beta blockers for high blood pressure

Rates for new cases of kidney failure have stabilized

Actos reduces the combined risk of non-fatal heart attacks, strokes in patients with type-2 diabetes

Quality-improvement improves mortality in hospital

Researchers map genetic location that explains why certain blood pressure-lowering drugs aren't effective for some people

Important new lessons learned from aspirin

Strokes and heart attacks can be prevented in people with high blood pressure

Benefits of starting CHF treatment with beta-blocker, bisoprolol

Nurse-led multidisciplinary programme can help coronary patients and their families to reduce their risk of major cardiovascular disease

Chronic heart failure (CHF) is common, deadly, disabling, costly but fortunately - treatable

International SHAPE project reveals massive public lack of awareness on heart failure

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