ACE Inhibitors News and Research

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ACE inhibitors act to reduce hypertension by interfering with the conversion of angiotensin I to artery-constricting angiotensin II. Blocking the production of angiotensin II results in arterial vasodilation and an accompanying reduction in blood pressure. ACE inhibitors currently are recommended as first-line therapy for hypertension in certain patient populations, because of their safety and efficacy.

Statins lessen heart attack risk

For patients with undiagnosed heart disease, taking medications known as statins and beta-blockers may mean the difference between suffering a heart attack as a first symptom versus experiencing mild chest pain.

24 Feb 2006

High blood pressure and kidney disease increase risk for heart disease and stroke in older Americans

Older Americans with high blood pressure and moderate to severe chronic kidney disease have a greater chance of developing heart disease than people with normal kidney function. This finding is one of three in a new paper published in the Feb. 7 issue of the Annals of Internal Medicine.

7 Feb 2006

$3.7 million to improve high blood pressure control

The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, has launched a $3.7 million, three-year educational effort to improve high blood pressure control nationwide.

5 Feb 2006

New treatment trials for autosomal dominant polycystic kidney disease

The National Institutes of Health (NIH) and the PKD Foundation have launched two treatment trials for autosomal dominant polycystic kidney disease (ADPKD).

25 Jan 2006

First-of-its-kind study in heart attack patients seeks to prevent heart failure with stem cells

University of Rochester Medical Center researchers have announced the launch of a study that will examine whether transplanted stem cells can be safely used to treat damaged heart muscle in patients just after their first heart attack.

23 Jan 2006

Heart patients don't stick to drug programs

A new report says that although people with coronary artery disease (CAD) are now more likely to use evidence-based therapies than they were a few years ago, there is still room for improvement.

10 Jan 2006

Coronary artery disease patients consistently fail to take life saving drugs

Nearly half the coronary artery disease (CAD) patients in a seven-year study admitted they don’t consistently take beta blockers, cholesterol-lowering drugs and other medications that could extend their lives, researchers report in Circulation: Journal of the American Heart Association.

10 Jan 2006

Quality of care for acute myocardial infarction in elderly patients with alcohol-related diagnoses

Older Americans with alcohol problems do not get worse treatment than their sober peers when they are hospitalized for a heart attack, according to new research on Medicare patients across the country.

6 Jan 2006

Implantable defibrillators benefit women as much as men after heart attack

Women who have had a heart attack get as much survival benefit as men from implanted cardioverter defibrillators (ICDs), devices designed to monitor the heart's pumping rhythm and shock it back to normal when needed, according to a study published in the December edition of the Journal of Cardiovascular Electrophysiology.

22 Dec 2005

Physicians slow to prescribe newer heart drugs

An analysis of the treatment received by more than 100,000 heart patients has shown that physicians' prescription practices for drugs proven effective for treating heart disease has shown steady improvement over the past three years, cardiologists at the Duke Clinical Research Institute (DCRI) have concluded.

7 Dec 2005

Aldosterone shows promise as stroke treatment

A bi-polar hormone that can contribute to strokes and minimize their damage is emerging as a therapeutic target in the battle against these brain attacks, researchers say.

5 Dec 2005

"Get With The Guidelines" programs improve care

After one year - Get With The GuidelinesSM programs used in hospitals significantly improved care for almost 30,000 coronary artery disease patients of all ages and sexes, according to research reported at the American Heart Association's Scientific Sessions 2005.

26 Nov 2005

Lack of aggressive treatment for clogged leg blood vessels means missed heart attack prevention opportunity

Despite the fact that clogged arteries in the legs usually mean clogged arteries near the heart, doctors often fail to give heart-protecting drugs to people with severe leg blood vessel blockages, a new University of Michigan-led study finds.

15 Nov 2005

Blood pressure near the heart is more predictive of cardiovascular outcomes than blood pressure measured in the arm

Results from a new study show that amlodipine-based (calcium channel blocker) treatment is much more effective at reducing blood pressure near the heart than a conventional atenolol-based (beta blocker) regimen.

14 Nov 2005

Early diagnosis and treatment of heart disease may lead to longer life in Duchenne and Becker muscular dystrophy patients

Cardiac disease, particularly dilated cardiomyopathy and heart failure, is the major cause of mortality in patients with muscular dystrophy and is present in most boys with Duchenne muscular dystrophy and approximately 70 percent of those with Becker muscular dystrophy. These are the two common forms of muscular dystrophy caused by defects in a gene called dystrophin.

30 Oct 2005

More doubt cast on benefit of beta blockers for high blood pressure

A comprehensive study has produced more evidence that a drug widely used to treat high blood pressure may not be the best option for many patients.

18 Oct 2005

Rates for new cases of kidney failure have stabilized

After 20 years of annual increases from 5 to 10 percent, rates for new cases of kidney failure have stabilized, according to new research from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). At the same time, dramatic racial disparities persist.

11 Oct 2005

Actos reduces the combined risk of non-fatal heart attacks, strokes in patients with type-2 diabetes

A study published in The Lancet shows that Takeda's Actos (pioglitazone HCl), an oral glucose lowering medication, significantly reduces the combined risk of non-fatal heart attacks, strokes and deaths by an additional 16% on top of standard medication

10 Oct 2005

Quality-improvement improves mortality in hospital

Heart attack death rates dropped significantly at hospitals that participated in a quality-improvement process that increased the use of evidence-based therapies, according to a new study in the Oct. 4, 2005, issue of the Journal of the American College of Cardiology.

28 Sep 2005

Researchers map genetic location that explains why certain blood pressure-lowering drugs aren't effective for some people

"The findings bring us a step closer to developing targeted therapies for patients with high blood pressure who might otherwise be started on medications that won't help," said lead author Sandosh Padmanabhan, Ph.D.

26 Sep 2005